Protein Alignment OtopLb and otop2

DIOPT Version :10

• Sequence 1: NP_608758.1
• Gene: OtopLb / 33539
• FlyBaseID: FBgn0031514
• Length: 797
• Species: Drosophila melanogaster
• Sequence 2: XP_001338079.4
• Gene: otop2 / 494472
• ZFINID: ZDB-GENE-050104-2
• Length: 572
• Species: Danio rerio
• Alignment Length: 610
• Identity: 128/610 - (20%)
• Similarity: 223/610 - (36%)
• Gaps: 187/610 - (30%)

  Fly   254 VLLGVCLPITEVISD-QIPTYVYQGFYVYLYVGSILFVIFLYISAFRNRSLFNALKDYHEKNSNV 317
            :|||:.:....|.:. ||.:.....|.:.|.:.|.:::::                 |....|.|
Zfish    70 LLLGIAIVSGSVFNKVQITSSHLLIFLILLVILSTVWMLY-----------------YKVHTSRV 117

  Fly   318 H--LKHKVTHFGSFYLRVGAIAFAIGTMVYSGLEFGQFFELNGHPGCRDVFVAITPICRMVLCIA 380
            :  :.:|.:|.|..:||.|.:.|.|.:::   ::..:.....|...|........|:.:.|..|.
Zfish   118 YRAVLYKDSHAGPVWLRTGLVLFGICSVI---MDIFKIIFYVGRMNCESPVKIAFPVVQAVFVIV 179

  Fly   381 QVQFIFLNTTYMDMARHKVTSRFGLMHMVATNLCEWLYVLVEETKHEIFHISQHEVDPAHDLVIH 445
            |...::::.......:..:| |.|||..::|||..|:..:.||:.|:       .|.|......:
Zfish   180 QTYVLWIHAKDCVQIKQNIT-RCGLMLTLSTNLMVWMMAVTEESLHQ-------TVAPVKPPTNN 236

  Fly   446 NSSMSRTDWAAVNESLHQHHHHHALNNTLVANVSSVIVNMTITPSPTPAAFSGCSRTTIMGALVQ 510
            ||                      .|:||...                ||.|.|.....|..|.:
Zfish   237 NS----------------------YNDTLDGR----------------AAASECECLHNMCDLFE 263

  Fly   511 QLSPFLFPCTIEYSLICAVILFEMWKTV-KSIPDIDKTRKNSVKPAAAKPAHHFSVDCSQSHK-- 572
            :...:|:|..|||||..:.:.:.|||.| :.:.|                 ||       |||
Zfish   264 KAYYYLYPFNIEYSLFASAMTYVMWKNVGRKMDD-----------------HH-------SHKLH 304

  Fly   573 --------GLFFGILIIVMTIISMIMYFVLYTQPGYELVATQEVTLWETFM----YFMCAAAVIT 625
                    |...|::::|..:.:.::|.|..::.  :....:|..:....|    ..:.:::.:.
Zfish   305 FSLWDVLVGPLAGLIVLVAGLATFVVYEVDVSKD--DPKKKEEALIMHYIMNIVAVLLMSSSALA 367

  Fly   626 GMILMR-DLRYIKNTSDEHHSMDLDNLLLIVAQTGVYLYGMFSILGSYFAKWDTVPDRVEG---- 685
            |.||.| |.|  :..|.::.:..||..||:.|..|.:|...|:|:.       .:...|:|
Zfish   368 GCILFRMDKR--EQVSGKNPTRSLDVGLLVGASLGQFLICYFTIVA-------VLASGVQGHTNG 423

  Fly   686 --IIAEVFGVVQTSLQTMFILHSSHRR-------------------------------------- 710
              :...:..|::..:|..|::...||.
Zfish   424 LNLACAMLTVIELCIQNAFLIKGLHREPFKETEVATVFANVMAVKERDPERRSSSIVPAHTLPIP 488

  Fly   711 ---CRGTNQVRRKPGREIITFLLVANIAIW----------FVNTLIKGRAVFRESHLEFFGVWGW 762
               .:|....:|:..:||..|||:.|:.:|          |.||:  |..|:     ||   ..|
Zfish   489 LTLLQGRMSWKRRVLKEICAFLLLCNVTLWIIPAFGARPQFDNTV--GPDVY-----EF---QTW 543

  Fly   763 TIITHISMPLAIFYRFHSTICLFEV 787
            ..:.:|.||..||||.||...||||
Zfish   544 AAVVNIGMPFGIFYRMHSVASLFEV 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLb	NP_608758.1	Otopetrin	330..778	CDD:460840	106/520 (20%)
otop2	XP_001338079.4	Otopetrin	133..558	CDD:460840	105/518 (20%)