Protein Alignment OtopLb and Otop1

DIOPT Version :10

• Sequence 1: NP_608758.1
• Gene: OtopLb / 33539
• FlyBaseID: FBgn0031514
• Length: 797
• Species: Drosophila melanogaster
• Sequence 2: NP_852098.1
• Gene: Otop1 / 305427
• RGDID: 631389
• Length: 600
• Species: Rattus norvegicus
• Alignment Length: 711
• Identity: 149/711 - (20%)
• Similarity: 246/711 - (34%)
• Gaps: 230/711 - (32%)

  Fly   190 QGTASGSTATINFQSGATSAR-NGSTAFFDNGAKSFQAKQQKDKNRRTGN--DAISSALSATY-- 249
            :|..|...|:    ||:.||. :|..|.....:...:|..|....||..:  ..::..||:.|
  Rat     5 RGALSSPAAS----SGSPSAAPSGIAACPPPPSPLARASPQASGPRRGASVPQKLAETLSSQYGL 65

  Fly   250 ----CKLLVLLGVCLPITEVISDQI-----PTYVYQGFYVYLYVGSILFVIFLYISAFRNRSLFN 305
                ..||.||...:..|.|....:     ...:.|..::..|||          .::..|.|
  Rat    66 NVFVAGLLFLLAWAVHATGVGKSDLLCVLTALMLLQLLWMLWYVG----------RSYMQRRL-- 118

  Fly   306 ALKDYHEKNSNVHLKHKVTHFGSFYLRVGAIAFAIGTMVYSGLEFGQFFELNGHPGCRDVFVAIT 370
                         ::.|.||.|:.:||.....||..|:|...|:...|.   |...|......:.
  Rat   119 -------------IRPKDTHAGARWLRGSITLFAFITIVLGCLKVAYFI---GFSECLSATEGVF 167

  Fly   371 PICRMVLCIAQVQFIFLNTTYMDMARHKVTSRFGLMHMVATNLCEWLYVLVEETKHEIFHISQHE 435
            |:...|..:.||.|::.:...:.|: .|...|||::|.|.|||..|...::.|:||::
  Rat   168 PVTHAVHTLLQVYFLWGHAKDIIMS-FKTLERFGVIHSVFTNLLLWANSVLNESKHQL------- 224

  Fly   436 VDPAHDLVIHNSSMSRTDWAAVNESLHQHHHHHALNNTLVANVSSVIVNMTITPSPTPAAFSGCS 500
                                  ||      |...|......|::.|:.:.|...:.||.|.  ||
  Rat   225 ----------------------NE------HKERLITLGFGNITIVLDDHTPQCNCTPPAL--CS 259

  Fly   501 RTTIMGALVQQLSPFLFPCTIEYSLICAVILFEMWKTVKSIPDIDKTRKNSVKPAAAKPAHHFSV 565
                  ||...:. :|:|..|||.::.:.:|:.:||.:..  .:|.:|             |..:
  Rat   260 ------ALSHGIY-YLYPFNIEYQILASTMLYVLWKNIGR--RVDSSR-------------HQKM 302

  Fly   566 DCSQSH--KGLFFGILIIVMTIISMIMY-----------------FVLYTQPGYELVATQEVTLW 611
            .|....  .|...|:.::..||..:::|                 |.||.
  Rat   303 QCRFDGVLVGSVLGLTVLAATIAVVVVYMIHIGRSKSKSESALIMFYLYA--------------- 352

  Fly   612 ETFMYFMCAAAVITGMILMRDLRYIKNTSDEHHSMDLDNLLLIVAQTGVYLYGMFSILGSYFAK- 675
            .|.:..|.||.::...|...|.:.:..:.:....:|.|  ||:...:|.:|....|||....|:
  Rat   353 ITVLLLMGAAGLVGSWIYRVDEKSLDESKNPARKLDAD--LLVATASGSWLLSWGSILAIACAET 415

  Fly   676 -----WDTVPDRVEGIIAEVFGVVQTSLQTMFILHSSH--------------------------- 708
                 |..:|       ..|..:|:..:|.:||:.|.|
  Rat   416 RPPYTWYNLP-------YSVLVIVEKYVQNIFIIESVHLEPEGVPEDVRTLRVVTVCSGEAAALA 473

  Fly   709 ------------------------RRCRGTNQ--------------------VRRKPGREIITFL 729
                                    :||...:|                    ::|:..|.|..||
  Rat   474 ASSLGSQGTAQDGSPAVNGNLHLQQRCEKEDQEADWEGATGTTRCLDFLQGGMKRRLLRNITAFL 538

  Fly   730 LVANIAIWFVNTLIKGRAVFRESHLE--FFGVWGWTIITHISMPLAIFYRFHSTICLFEVW 788
            .:.||::|.....  |.....::.||  .||...|.|:.:::||.:||||.|:...||||:
  Rat   539 FLCNISLWIPPAF--GCRPEYDNGLEEIVFGFEPWIIVVNLAMPFSIFYRMHAAAALFEVY 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLb	NP_608758.1	Otopetrin	330..778	CDD:460840	111/545 (20%)
Otop1	NP_852098.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		13/48 (27%)
		Otopetrin	131..586	CDD:460840	110/543 (20%)
		putative FYR-box	584..596		6/11 (55%)