Protein Alignment OtopLb and Otop3

DIOPT Version :10

• Sequence 1: NP_608758.1
• Gene: OtopLb / 33539
• FlyBaseID: FBgn0031514
• Length: 797
• Species: Drosophila melanogaster
• Sequence 2: NP_001426609.1
• Gene: Otop3 / 287821
• RGDID: 1306663
• Length: 578
• Species: Rattus norvegicus
• Alignment Length: 651
• Identity: 137/651 - (21%)
• Similarity: 228/651 - (35%)
• Gaps: 210/651 - (32%)

  Fly   221 AKSFQAKQQKDKNRRTGNDAISSALSATYCKLLVLLG---VCLPITEVISDQIPTYVYQG----F 278
            |..|....::|:..:......|..|:..    :|.||   :|..|...::      |..|    .
  Rat    52 ALHFSLLLRRDRQAQKAGQLFSGLLALN----VVFLGGAFICSMIFNKVA------VTLGDVWIL 106

  Fly   279 YVYLYVGSILFVIFLYISAFRNRSLFNALKDYHEKNSNVHLKHKV----THFGSFYLRVGAIAFA 339
            ...|.|.|:|::::..:...|.                   .|.|    .|.|..::|...:.|.
  Rat   107 LAALKVLSLLWLLYYTVGTTRK-------------------PHAVLYRDPHAGPVWVRGSLVLFG 152

  Fly   340 IGTMVYSGLEFGQFFELNGHPGCRDVFVAITPICRMVLCIAQVQFIFLNTTYMDMARHKVTSRFG 404
            ..|:..:....|  :::: |..|:.....|.|...:|..|.|...::.:.......:...| |.|
  Rat   153 SCTVCLNVFRMG--YDVS-HIHCKSEVELIFPAIEIVFMIIQTWVLWKHCKDCVQVQTNFT-RCG 213

  Fly   405 LMHMVATNLCEWLYVLVEETKHEIFHISQHEVDPAHDLVIHNSSMSRTDWAAVNESLHQHHHHHA 469
            ||..:||||..|:..:..::.|       .|::...|.::...|.:.|
  Rat   214 LMLTLATNLLMWVLAVTNDSMH-------REIEAELDALMEKFSGNGT----------------- 254

  Fly   470 LNNTLVANVSSVIVNMTITPSPTPAAFSGCSRTTI-----MGALVQQLSPFLFPCTIEYSLICAV 529
              ||.:                       |...|:     .|.|:      |:|.:.||.|||..
  Rat   255 --NTCM-----------------------CLNATVCEVFRKGFLM------LYPFSTEYCLICCA 288

  Fly   530 ILFEMWKTVKSIPDIDKTRKNSVKPAAAKPAHHFSVDCSQSHKGLFFGILIIVMTIISMIMYFVL 594
            :||.|||.|.             :..||....|.:....:.| |..||.|:.::.:::.:..|||
  Rat   289 VLFVMWKNVG-------------RSLAAHSGAHPNRPPFRLH-GAIFGPLLGLLALVAGVCVFVL 339

  Fly   595 Y----TQPGYELVATQEVTLWETF-------MYFMCAAAVITGMILMRDLRYIKNTSDEHHSMDL 648
            :    :.|.   :|.|..||:..|       |...|.|......:..|:|..:||.     :..|
  Rat   340 FQIEASGPD---IARQYFTLYYAFYVAVLPTMSLACLAGTAIHGLEERELDTLKNP-----TRSL 396

  Fly   649 DNLLLI---VAQTGVYLYGMFSILGSYFAKWDTVPDRV--EGIIA-EVFGVVQTSLQTMFILHSS 707
            |.:||:   :.|.|:..:.:.:|:.       |.|.::  :.|:| .:..::|...|.:||:...
  Rat   397 DVVLLMGAALGQMGIAYFSIVAIVA-------TQPHQLLNQLILAYSLLLILQHITQNLFIIEGL 454

  Fly   708 HRR-----------------------CRGTNQVRRKPGR-----------------EIITFLLVA 732
            |||                       .|...|..|:..|                 ||..||::.
  Rat   455 HRRPLWEPVISGVPEKQDIELPRRGSLRELGQDLRRASRAYIHSFSHLNWKRRMLKEISLFLILC 519

  Fly   733 NIAIW----------FVNTLIKGRAVFRESHLEFFGVWGWTIITHISMPLAIFYRFHSTICLFEV 787
            ||.:|          |.|.|.|          :|:|...|..|.:..:||.:|||.||...|.||
  Rat   520 NITLWMMPAFGIHPEFENGLEK----------DFYGYRTWFTIVNFGLPLGVFYRMHSVGGLVEV 574

  Fly   788 W 788
            :
  Rat   575 Y 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLb	NP_608758.1	Otopetrin	330..778	CDD:460840	110/519 (21%)
Otop3	NP_001426609.1	None