Protein Alignment OtopLb and Otop2

DIOPT Version :10

• Sequence 1: NP_608758.1
• Gene: OtopLb / 33539
• FlyBaseID: FBgn0031514
• Length: 797
• Species: Drosophila melanogaster
• Sequence 2: NP_001099321.1
• Gene: Otop2 / 287820
• RGDID: 1304830
• Length: 563
• Species: Rattus norvegicus
• Alignment Length: 636
• Identity: 137/636 - (21%)
• Similarity: 233/636 - (36%)
• Gaps: 209/636 - (32%)

  Fly   254 VLLGVCLPITEVISDQIPTYVYQGFYVYLYVGSILFVIFLYISAFRNRSLFNALKDYHEKNSNVH 318
            |||..|..|:....:::..|...   |:..:.:::.:..|:|       :|..|:.....::
  Rat    39 VLLLACTLISGGAFNKVAVYDTD---VFALLTTMMLLAALWI-------IFYLLRTARSPDA--- 90

  Fly   319 LKHKVTHFGSFYLRVGAIAFAIGTMVYSGLEFG---QFFELNGHPGCRDVFVAITPICRMVLCIA 380
            :.::..|.|..:||.|.:.|.|.|:|....:.|   .|||      |:.....:.||.:.|..|.
  Rat    91 VPYRDAHAGPIWLRGGLVLFGICTLVMDVFKTGYYSSFFE------CQSAIKILHPITQAVFVIV 149

  Fly   381 QVQFIFLNT-----TYMDMARHKVTSRFGLMHMVATNLCEWLYVLVEETKHEIFHISQHEVDPAH 440
            |..|::::.     |::|:      :|.|||..:||||..|:
  Rat   150 QTYFLWISAKDCIHTHLDL------TRCGLMFTLATNLAIWM----------------------- 185

  Fly   441 DLVIHNSSMSRTDWAAVNESLHQHHHHHALNNTLVANVSSVIVNMTITPSPTPAAFSG----CSR 501
                         .|.|:||:||.|.....:    .|.|    :..:||....|..:.    |..
  Rat   186 -------------TAVVDESVHQAHSFSGFH----GNTS----HTRLTPDSERAGGTAEGDPCPC 229

  Fly   502 TTIMGALVQQLSPFLFPCTIEYSLICAVILFEMWKTVKSIPDIDKTRKNSVKPAAAKPAHHFSVD 566
            :|.:..:.||...:|:|..|||||..:.:|:.|||.|..:             .|:...|..:..
  Rat   230 STAICQIFQQGYFYLYPFNIEYSLFASTMLYVMWKNVGRL-------------LASAHGHGHTPS 281

  Fly   567 CSQSHKGLFF-----GILIIVMTIISMIMYFVLYTQPGYELVATQEVTLWETFMYFMCAAAV--- 623
            .....:..||     |:|:.|:.:...|:|.|   |...|...||:..:.......:|...:
  Rat   282 RVSLFRETFFAGPVLGLLLFVVGLAVFILYEV---QVSGERGHTQQALVIYYSFNIVCLGLMTLV 343

  Fly   624 -ITGMILMR-DLRYIKNTSDEHH---SMDLDNLLLIVAQTGVYLYGMFSILGSYFAKWDTVPDRV 683
             ::|.::.| |.|.:     :||   :..||..||:.|..|.|....:||:..           |
  Rat   344 SLSGSVIYRFDRRAM-----DHHKNPTRTLDVALLMGAALGQYAISYYSIVAV-----------V 392

  Fly   684 EGIIAEVFG----------VVQTSLQTMFILHSSHR----------------------------- 709
            .|...::.|          :.|.:.|.:||:.|.||
  Rat   393 VGSPRDLLGALNLSHALLMIAQHTFQNVFIIESLHRGPPGAEPRETPPKELYQGITFANLSAIHT 457

  Fly   710 --RCRGTNQV----------------------RRKPGREIITFLLVANIAIW----------FVN 740
              .|..|.::                      ||:..::|..|||:.|:.:|          |.|
  Rat   458 LPSCPPTPRLVSPNPEGPQEAVAIVSAPRCHWRRRCLKDISLFLLLCNVILWIMPAFGARPHFSN 522

  Fly   741 TLIKGRAVFRESHLEFFGVWGWTIITHISMPLAIFYRFHSTICLFEVWKIT 791
            |:          .::|:|...|..|.:|.:|..||||.|:...|.||:.::
  Rat   523 TV----------EVDFYGYSLWAAIVNICLPFGIFYRMHAVSSLLEVYVLS 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLb	NP_608758.1	Otopetrin	330..778	CDD:460840	119/545 (22%)
Otop2	NP_001099321.1	Otopetrin	103..549	CDD:460840	118/543 (22%)