Protein Alignment OtopLb and Otop1

DIOPT Version :10

• Sequence 1: NP_608758.1
• Gene: OtopLb / 33539
• FlyBaseID: FBgn0031514
• Length: 797
• Species: Drosophila melanogaster
• Sequence 2: NP_766297.2
• Gene: Otop1 / 21906
• MGIID: 2388363
• Length: 600
• Species: Mus musculus
• Alignment Length: 731
• Identity: 153/731 - (20%)
• Similarity: 247/731 - (33%)
• Gaps: 254/731 - (34%)

  Fly   175 GNGFLSPRTAKNGNLQGTASGSTATINFQSGATSARNGSTAFFDNGAKSFQAKQQKDKNRRTGND 239
            |.|..|...|.:|:.:...||..|..  .|....||....|   :|.:...:..||
Mouse     4 GPGAPSSPAASSGSSRAAPSGIAACP--LSPPPLARGSPQA---SGPRRGASVPQK--------- 54

  Fly   240 AISSALSATY------CKLLVLLGVCLPITEVISDQI-----PTYVYQGFYVYLYVGSILFVIFL 293
             ::..||:.|      ..||.||...:..|.|....:     ...:.|..::..|||
Mouse    55 -LAETLSSQYGLNVFVAGLLFLLAWAVHATGVGKSDLLCVLTALMLLQLLWMLWYVG-------- 110

  Fly   294 YISAFRNRSLFNALKDYHEKNSNVHLKHKVTHFGSFYLRVGAIAFAIGTMVYSGLEFGQFFELNG 358
              .::..|.|               ::.|.||.|:.:||.....||..|:|...|:...|.   |
Mouse   111 --RSYMQRRL---------------IRPKDTHAGARWLRGSITLFAFITVVLGCLKVAYFI---G 155

  Fly   359 HPGCRDVFVAITPICRMVLCIAQVQFIFLNTTYMDMARHKVTSRFGLMHMVATNLCEWLYVLVEE 423
            ...|......:.|:...|..:.||.|::.:...:.|: .|...|||::|.|.|||..|...::.|
Mouse   156 FSECLSATEGVFPVTHAVHTLLQVYFLWGHAKDIIMS-FKTLERFGVIHSVFTNLLLWANSVLNE 219

  Fly   424 TKHEIFHISQHEVDPAHDLVIHNSSMSRTDWAAVNESLHQHHHHHALNNTLVANVSSVIVNMTIT 488
            :||::                             ||      |...|......|::.|:.:.|..
Mouse   220 SKHQL-----------------------------NE------HKERLITLGFGNITIVLDDHTPQ 249

  Fly   489 PSPTPAAFSGCSRTTIMGALVQQLSPFLFPCTIEYSLICAVILFEMWKTVKSIPDIDKTRKNSVK 553
            .:.||.|.  ||      ||...:. :|:|..|||.::.:.:|:.:||.:..
Mouse   250 CNCTPPAL--CS------ALSHGIY-YLYPFNIEYQILASTMLYVLWKNIGR------------- 292

  Fly   554 PAAAKPAHHFSVDCSQSHK----------GLFFGILIIVMTIISMIMY----------------- 591
                      .||.||..|          |...|:.::..||..:::|
Mouse   293 ----------RVDSSQHQKMQCRFDGVLVGSVLGLTVLAATIAVVVVYMIHIGRSKSKSESALIM 347

  Fly   592 FVLYTQPGYELVATQEVTLWETFMYFMCAAAVITGMILMRDLRYIKNTSDEHHSMDLDNLLLIVA 656
            |.||.               .|.:..|.||.::...|...|.:.:..:.:....:|:|  ||:..
Mouse   348 FYLYA---------------ITVLLLMGAAGLVGSWIYRVDEKSLDESKNPARKLDVD--LLVAT 395

  Fly   657 QTGVYLYGMFSILGSYFAK------WDTVPDRVEGIIAEVFGVVQTSLQTMFILHSSH------- 708
            .:|.:|....|||....|:      |..:|       ..|..:|:..:|.:||:.|.|
Mouse   396 GSGSWLLSWGSILAIACAETRPPYTWYNLP-------YSVLVIVEKYVQNIFIIESVHLEPEGVP 453

  Fly   709 --------------------------------------------RRC------------RGTNQ- 716
                                                        :||            .||.:
Mouse   454 EDVRTLRVVTVCSSEAAALAASTLGSQGMAQDGSPAVNGNLCLQQRCGKEDQESGWEGATGTTRC 518

  Fly   717 -------VRRKPGREIITFLLVANIAIWFVNTLIKGRAVFRESHLE--FFGVWGWTIITHISMPL 772
                   ::|:..|.|..||.:.||::|.....  |.....::.||  .||...|.|:.:::||.
Mouse   519 LDFLQGGMKRRLLRNITAFLFLCNISLWIPPAF--GCRPEYDNGLEEIVFGFEPWIIVVNLAMPF 581

  Fly   773 AIFYRFHSTICLFEVW 788
            :||||.|:...||||:
Mouse   582 SIFYRMHAAAALFEVY 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLb	NP_608758.1	Otopetrin	330..778	CDD:460840	113/553 (20%)
Otop1	NP_766297.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		13/50 (26%)
		Otopetrin	131..586	CDD:460840	112/551 (20%)