Protein Alignment OtopLb and otpl-8

DIOPT Version :10

• Sequence 1: NP_608758.1
• Gene: OtopLb / 33539
• FlyBaseID: FBgn0031514
• Length: 797
• Species: Drosophila melanogaster
• Sequence 2: NP_510045.2
• Gene: otpl-8 / 186752
• WormBaseID: WBGene00010403
• Length: 619
• Species: Caenorhabditis elegans
• Alignment Length: 624
• Identity: 171/624 - (27%)
• Similarity: 271/624 - (43%)
• Gaps: 122/624 - (19%)

  Fly   231 DKNRRTGNDAISSALSAT-------------------YCKLLV-LLGVCLPITEVISDQIPTY-- 273
            |...:.|:|:.|...|.|                   :.:|:. |..:.|.|..::.:..||:
 Worm    27 DDMEKGGSDSDSLPSSPTHHHELYRRPWIHEPRATNFFVRLITSLYALILTIISLVVEVSPTWRT 91

  Fly   274 ----VYQGFYVYLYVGSILFVIFLYISAF---RNRSLFNALKDYH-EKNSNV----HLKHKVTHF 326
                ....||:.:|...|||..:.||...   ....|.:.|:.|. .|||.|    ..:|.....
 Worm    92 DMWLAETIFYISMYGVGILFFAYCYIFIIYPGPYNQLISVLRKYKIIKNSEVWFIMQSQHNGEGA 156

  Fly   327 GSFYLRVGAIAFAIGTMVYSGLEFGQFFELNGHPGCRDVFVAITPICRMVLCIAQVQFIFLNTTY 391
            |:.|||:||:.|....:|..|||.....|   :..|:.|.:| ..|..:|....|:.|||.|:..
 Worm   157 GTLYLRLGALFFGSVGIVLFGLELFLCIE---NVACKKVAIA-KMIVAIVFTFIQMHFIFCNSKI 217

  Fly   392 MDMARHKVTSRFGLMHMVATNLCEWL-YVLV-EETK-HEIFHISQHEVDPAHDLVIHNSSMSRTD 453
            ...:..|:.: ||:||:::.||..|. :||. :|.| |:...:.|       ....:.||.|
 Worm   218 TVNSSRKIVA-FGMMHLISVNLWTWFRFVLAKQEAKAHKKAQLKQ-------TFRKYYSSSS--- 271

  Fly   454 WAAVNESLHQHHHHHALNNTLVANVSSVIVNMTITPSPTPAAFSGCSRTTIMGALVQQL------ 512
             ::.:|.:|:              :.|.::|.|:..:|.         |..|..:..:|
 Worm   272 -SSSSEEIHE--------------LISAVLNSTLNNTPA---------TKTMEPVASRLFALEHF 312

  Fly   513 ---SPFLFPCTIEYSLICAVILFEMWKTVKSIPDIDKTRKNSVKPAAAKPAHHFSVDCSQSHKGL 574
               :.||..|.:|||||.|.|:|.:||::        .:.|..:..:.|......:|||.|..||
 Worm   313 GDVATFLTTCIVEYSLIGAAIMFILWKSI--------GQNNHQQSNSGKRKVKMRIDCSSSSTGL 369

  Fly   575 FFGILIIVMTIISMIMYFV---LYTQPGYELVATQEVTLWETFMYFMCAAAVITGMILMRDLRYI 636
            |.||:.::.:::||.||.:   |....|.:||    ..:.:..::.:...|.|.|:..||.|:|.
 Worm   370 FAGIIFLIGSLVSMGMYTIFESLRNSSGAQLV----FGIVDLSLFSIALGACIIGLWRMRHLQYR 430

  Fly   637 KNTSDEHHSMDLDNLLLIVAQTGVYLYGMFSILGSYFAKWDTVPD-RVEGIIAEVFGV--VQTSL 698
            .:.    |...:|.:|||:...|..||....|  ..|.......| .|..:.|.||.:  :|..:
 Worm   431 LHA----HGEVIDEILLIIGLIGEILYCAVGI--DVFITCRRSADLTVSALPAFVFVIRMIQVVV 489

  Fly   699 QTMFILHSSHRRCRGTNQVRRKPGREIITFLLVANIAIWFVNTLIKGRAVFRESHLEFFG----- 758
            |..|||.:|..||.....::.|||:||||||||:|:.::..:|.        |.....||
 Worm   490 QAAFILTTSRLRCLSKYSMKYKPGKEIITFLLVSNVTLFVFHTF--------EGMKSSFGFSSKA 546

  Fly   759 VWGWTIITHISMPLAIFYRFHSTICLFEVWKITYKAKAH 797
            ...:..|.:...||.:||||||:.||.|:||.||..|::
 Worm   547 ATQYNYIIYAVGPLLVFYRFHSSACLAEIWKHTYSTKSN 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLb	NP_608758.1	Otopetrin	330..778	CDD:460840	130/470 (28%)
otpl-8	NP_510045.2	Otopetrin	160..566	CDD:460840	130/470 (28%)