Protein Alignment OtopLb and OTOP1

DIOPT Version :9

• Sequence 1: NP_608758.1
• Gene: OtopLb / 33539
• FlyBaseID: FBgn0031514
• Length: 797
• Species: Drosophila melanogaster
• Sequence 2: NP_819056.1
• Gene: OTOP1 / 133060
• HGNCID: 19656
• Length: 612
• Species: Homo sapiens
• Alignment Length: 708
• Identity: 143/708 - (20%)
• Similarity: 252/708 - (35%)
• Gaps: 208/708 - (29%)

  Fly   189 LQGTASGSTATINFQSGATSARNGSTAFFDNGAKSFQAKQQKDKNRRTGNDA-----ISSALSAT 248
            |:|.  ||.|:....:.|:.|.:...|.....:.|.....:....||.|..|     ::..||:.
Human     2 LEGL--GSPASPRAAASASVAGSSGPAACSPPSSSAPRSPESPAPRRGGVRASVPQKLAEMLSSQ 64

  Fly   249 YCKLLVLLGVCLPITEVI-------SDQIPTYVYQGFYVYLYVGSILFVIFLYISAFRNRSLFNA 306
            |..::.:.|:.|.:...:       ||.:      .|...|.:..:|::::....:..:|.||.
Human    65 YGLIVFVAGLLLLLAWAVHAAGVSKSDLL------CFLTALMLLQLLWMLWYVGRSSAHRRLFR- 122

  Fly   307 LKDYHEKNSNVHLKHKVTHFGSFYLRVGAIAFAIGTMVYSGLEFGQFFELNGHPGCRDVFVAITP 371
            |||              ||.|:.:||.....||:.|::...|:.|.|.   |...|......:.|
Human   123 LKD--------------THAGAGWLRGSITLFAVITVILGCLKIGYFI---GFSECLSATEGVFP 170

  Fly   372 ICRMVLCIAQVQFIFLNTTYMDMARHKVTSRFGLMHMVATNLCEWLYVLVEETKHEIFHISQHEV 436
            :...|..:.||.|::.:...: :...|...|||::|.|.|||..|...::.|:||::
Human   171 VTHSVHTLLQVYFLWGHAKDI-IQSFKTLERFGVIHSVFTNLLLWANGVLNESKHQL-------- 226

  Fly   437 DPAHDLVIHNSSMSRTDWAAVNESLHQHHHHHALNNTLVANVSSVIVNMTITPSPTPAAFSGCSR 501
                                 ||      |...|......|::      |:....||..  .|:.
Human   227 ---------------------NE------HKERLITLGFGNIT------TVLDDHTPQC--NCTP 256

  Fly   502 TTIMGALVQQLSPFLFPCTIEYSLICAVILFEMWKTVKSIPDIDKTRKNSVKPAAAKPAHHFSVD 566
            .|:..|:...:. :|:|..|||.::.:.:|:.:||.:....|..:.:|...|.....
Human   257 PTLCTAISHGIY-YLYPFNIEYQILASTMLYVLWKNIGRKVDSHQHQKMQFKSDGVM-------- 312

  Fly   567 CSQSHKGLFFGILIIVMTIISMIMYFVLYTQPGYELVATQEVTLWETFMYFMCAAAVI-----TG 626
                 .|...|:.::..||..:::|.:   ..|.....::...:    |:::.|..::     .|
Human   313 -----VGAVLGLTVLAATIAVVVVYLI---HIGRSKTKSESALI----MFYLYAITLLMLMGAAG 365

  Fly   627 MILMRDLRYIKNTSDE--HHSMDLDNLLLIVAQTGVYLYGMFSILGSYFAK------WDTVPDRV 683
            :..:|..|..:.:.||  :.:..||:.||:...:|.:|....|||....|:      |..:|
Human   366 LAGIRIYRIDEKSLDESKNPARKLDSDLLVGTASGSWLISWGSILAILCAEGHPRYTWYNLP--- 427

  Fly   684 EGIIAEVFGVVQTSLQTMFILHSSHRR----------------CRGT------------------ 714
                ..:..:|:..:|.:||..|.||.                |.|.
Human   428 ----YSILAIVEKYIQNLFIFESIHREPEKLSEDIQTLRVVTVCNGNTMPLASSCPKSGGVARDV 488

  Fly   715 -----------------------------------------------NQVRRKPGREIITFLLVA 732
                                                           ...:||..|.|..||.:.
Human   489 APQGKDMPPAANGNVCMRESHDKEEEKQEESSWGGSPSPVRLPRFLQGNAKRKVLRNIAAFLFLC 553

  Fly   733 NIAIWFVNTLIKGRAVFRESHLE--FFGVWGWTIITHISMPLAIFYRFHSTICLFEVW 788
            ||::|.....  |.....::.||  .||...|.|:.:::||.:||||.|:...||||:
Human   554 NISLWIPPAF--GCRPEYDNGLEEIVFGFEPWIIVVNLAMPFSIFYRMHAAASLFEVY 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLb	NP_608758.1	Otopetrin	330..778	CDD:281218	105/543 (19%)
OTOP1	NP_819056.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		12/49 (24%)
		Otopetrin	133..598	CDD:281218	104/541 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	499..525		0/25 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4740
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I4547
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8528
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21522
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.930