Protein Alignment OtopLb and OtopLa

DIOPT Version :10

• Sequence 1: NP_608758.1
• Gene: OtopLb / 33539
• FlyBaseID: FBgn0031514
• Length: 797
• Species: Drosophila melanogaster
• Sequence 2: XP_061517861.1
• Gene: OtopLa / 1272290
• VectorBaseID: AGAMI1_000852
• Length: 1004
• Species: Anopheles gambiae
• Alignment Length: 1086
• Identity: 250/1086 - (23%)
• Similarity: 386/1086 - (35%)
• Gaps: 422/1086 - (38%)

  Fly    45 CEYITISAPKKSGSFSRSPPSSLPTSVPGTPRHSV-----------AATSNQVIRY--------- 89
            |.||.....:..|...|.|   ||.|.|...:..|           ...|.|::..
Mosquito     4 CPYIHEMHERLLGPTPRRP---LPISYPPLAKPEVMDRESDCLLDSRPESRQIVGTVVKLNPDGF 65

  Fly    90 -ARTSCDHCGHHSIPVMSPHPISPLAKSQTNLDLVEHGSQRQALLPLPTVGMHHEDSACTLQVSR 153
             |.|:..|..||                       .||.|:|
Mosquito    66 GAHTTSTHHHHH-----------------------HHGQQQQ----------------------- 84

  Fly   154 RPSLLLQEILTQRPPLF---GRRDGNGFLSPRTAKNGNLQGTASGSTATINFQSGATSARNGSTA 215
                  |:.|..|.||.   |..|.    ..||.::..|:......|:||:...
Mosquito    85 ------QQQLHHRTPLVPCNGTEDD----EVRTGRHHTLREGDGTITSTISDSD----------- 128

  Fly   216 FFDNG-------AKSFQAKQQKDKNRRTGNDAISSALSATYCKLLVLLGVCLPITEVISDQIPTY 273
              |:|       .|..:.:  |.||.:|   ::....|..|..||:::.|...|::|.:.::|..
Mosquito   129 --DDGIHLRTHLRKIIEGR--KPKNAKT---SLFIVTSLVYAMLLIVVCVAYVISDVTTHRLPVI 186

  Fly   274 VYQGFYVYLYVGSILFVIFLYISAFRNRSLFN--------------------------------- 305
            .|:||:.|||..||||:::::....:..|..|
Mosquito   187 YYEGFFTYLYGASILFLLYVFCFLLQESSCCNGKPKPPKEKKPKKEKKSKKNADVEAGKEGKDGK 251

  Fly   306 ---ALKD------------------------------------------YHEKNS---------- 315
               |.||                                          .|.:.|
Mosquito   252 EAGAAKDGAGKSTKEEPKGKGSSTKASSYQYSKKQEVYPKKKRDQLRASQHRRESGEVAVAEPAT 316

  Fly   316 -------------------------------NVHLKHKVTH---FGSFYLRVGAIAFAIGTMVYS 346
                                           :...|.|.|.   .|||:||||||||.:|||:|:
Mosquito   317 ERIAASPAMPTTTPPATQLQEAAQPNPEAAMSPRFKRKTTQDPAHGSFFLRVGAIAFGLGTMIYT 381

  Fly   347 GLEFGQFFELNGHPGCRDVFVAITPICRMVLCIAQVQFIFLNTTYMDMARHKVTSRFGLMHMVAT 411
            |||||.|||:.....|..:...:.|:.:|:....|:.|||:|.. :::.|.||.:||||||:|||
Mosquito   382 GLEFGSFFEIPFTSPCHQILRGVNPLLQMIFTFMQMYFIFMNAR-LNIHRFKVLARFGLMHIVAT 445

  Fly   412 NLCEWLYVLVEETKHEIFHISQHEVDPAHDLVI---------HNSSM----------SRTDWAAV 457
            |:|.|:..||.|:..||....|.......|.||         .|:.|          :.|:|..:
Mosquito   446 NICVWIRTLVLESLKEITAYHQRRGPEPEDSVILENIRQHTLRNAGMVMGMELAPGGTDTEWEPI 510

  Fly   458 NESLHQHHH-----------------HHALN---NTLVA-------------------NVSSVIV 483
            :.:|:....                 .|.:.   .|||:                   :.|:...
Mosquito   511 SVNLNAQEDLLSQDASSVLSKIVQGTAHTITEAATTLVSAATLTSTAAPTTTSSSTSTSTSTTTT 575

  Fly   484 NMTITPSPT-------------------------------------------------------- 492
            ..|.|.|||
Mosquito   576 TTTTTASPTTTPSWIEPSTGASSTTTARGLLDRIRDIVATETTTTYETPANHFGSAQHTLSTSAG 640

  Fly   493 -------------------------------------------PAAF-------------SGCSR 501
                                                       |:||             ..|.|
Mosquito   641 GVNATAATPSTGSSFLDSFMDHVNYLQRNSSLDQTYESLDALFPSAFIATSTAVSTNATAISCGR 705

  Fly   502 TTIMGALVQQLSPFLFPCTIEYSLICAVILFEMWKTVKSIP------DIDKTRKNSVKPAA---A 557
            ..|||.:||..:|:|:|..||||||.|.:::.|||.:...|      |::...:..:...|   |
Mosquito   706 VNIMGTIVQDSAPYLYPFIIEYSLIGAAVIYVMWKHIGRYPKFTNEEDLEHRLEVMLSRRAVVMA 770

  Fly   558 KPAHHFSVDCSQSHKGLFFGILIIVMTIISMIMYFVLYTQPGYELVATQEVTLWETFMYFMCAAA 622
            :.|....|||..:.||||||:|::|.::|.:|::|||...|...|:|.....:....:..:...|
Mosquito   771 QQARTGRVDCVGASKGLFFGLLLLVGSLICLILFFVLVRHPQLSLLAIYLADVSHCALMALAIFA 835

  Fly   623 VITGMILMRDLRYIKNTSDEHHSMDLDNLLLIVAQTGVYLYGMFSILGSYFAKWDTVPD---RVE 684
            :|.|.|.:::|::    ..|..| :|:::||.::..|:::|..||::......:::.|:   .|.
Mosquito   836 IIIGFIRVQNLKF----RCEEQS-NLNDILLRISAFGLFVYSTFSVIAGSLNAFESEPNLLVMVT 895

  Fly   685 GIIAEVFGVVQTSLQTMFILHSSHRRCRGTNQVRRKPGREIITFLLVANIAIWFVNTLIKGRAVF 749
            ||:|    |||..:|.:||...|.||.......|.||||:|:||||:.||:::.:.|....:...
Mosquito   896 GIVA----VVQVVIQLLFIADVSRRRVHLPEHDRIKPGRQIVTFLLICNISMFAIYTFEAQKVFA 956

  Fly   750 RESHLEFFGVWGWTIITHISMPLAIFYRFHSTICLFEVWKITYKAK 795
            ....|:|:|...|::|..:::||.||:||||.:.|.||||.||||:
Mosquito   957 NPVQLDFYGFIAWSLIQRVTLPLCIFHRFHSAVTLAEVWKTTYKAR 1002

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLb	NP_608758.1	Otopetrin	330..778	CDD:460840	164/629 (26%)
OtopLa	XP_061517861.1	None