DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3347 and CXXC1

DIOPT Version :9

Sequence 1:	NP_001285579.1	Gene:	CG3347 / 33538	FlyBaseID:	FBgn0031513	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001095124.1	Gene:	CXXC1 / 30827	HGNCID:	24343	Length:	660	Species:	Homo sapiens

Alignment Length:	485	Identity:	114/485 - (23%)
Similarity:	175/485 - (36%)	Gaps:	132/485 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VYCICRQSHINGFMICCDNCNEWFHGDCIGLPANIGEQHDTYYCTECFRKNPLLKCTY--KKSPS 84
            :|||||:..||.|||.|||||||||||||.:...:.:....:||.||..|:|.|:..|  |||..
Human    27 IYCICRKPDINCFMIGCDNCNEWFHGDCIRITEKMAKAIREWYCRECREKDPKLEIRYRHKKSRE 91

  Fly    85 TTGVPKTPKTPKTPKTPKNPKTPKTPKNSKTPKTARIINSIGVRQNPRRRSTFVQERPSEVPNP- 148
            ..|               |.:....|::..           |.|:.|             ||:|
Human    92 RDG---------------NERDSSEPRDEG-----------GGRKRP-------------VPDPD 117

  Fly   149 ---------------SRQSTKLQKAVNYENATEEPTEDAEKVDQKPKKTAKKKNPKPEDKVTDDA 198
                           :|.|....|: :.:.....|::..::..|:.|::|:........:.|:|.
Human   118 LQRRAGSGTGVGAMLARGSASPHKS-SPQPLVATPSQHHQQQQQQIKRSARMCGECEACRRTEDC 181

  Fly   199 QKPAVEKLFESKGTQCNMFRDWSKYVPPENSKKRGTCFTVFCQQLARSCSRYCCDECGNFTAITN 263
                         ..|:..||..|:..|  :|.|..|....||..||...:|
Human   182 -------------GHCDFCRDMKKFGGP--NKIRQKCRLRQCQLRARESYKY------------- 218

  Fly   264 VFALGLLPNMPAMKVAMGHVGLLLGNDLTNNQKSNKNSE---ASESKTETKP----KVKKPKSE- 320
             |...|.|..|:..:......|........:||..:..|   |..|.|..:|    ...:|.|:
Human   219 -FPSSLSPVTPSESLPRPRRPLPTQQQPQPSQKLGRIREDEGAVASSTVKEPPEATATPEPLSDE 282

  Fly   321 --------------GRKSRYRSP-SSSLERSPDVSRTAAKRPKLQEELPSSSSRSSRKLVE--ES 368
                          |....:..| .|..|.||.:.....||....:.:.....:|.:|::|  |.
Human   283 DLPLDPDLYQDFCAGAFDDHGLPWMSDTEESPFLDPALRKRAVKVKHVKRREKKSEKKVMERKEE 347

  Fly   369 RSETERHKAKHKTSKK--EKTSSQRAYSLSPIPSPKSYRAARNTSETAPNS-------------- 417
            |.:..|.|.|||...|  |:..::...||.....|...|.|:.:|:...:.
Human   348 RYKRHRQKQKHKDKWKHPERADAKDPASLPQCLGPGCVRPAQPSSKYCSDDCGMKLAANRIYEIL 412

  Fly   418 PVNLKKTFKQKHVISSPTGKK---RVCRSQ 444
            |..::: ::|...|:...|||   |:.|.|
Human   413 PQRIQQ-WQQSPCIAEEHGKKLLERIRREQ 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3347	NP_001285579.1	PHD_SF	23..68	CDD:304600	25/44 (57%)
CXXC1	NP_001095124.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		PHD_Cfp1	28..73	CDD:277028	25/44 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..162		18/117 (15%)
		zf-CXXC	162..208	CDD:366873	12/60 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..287		14/67 (21%)
		zf-CpG_bind_C	406..640	CDD:403474	9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1632
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4178
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D463371at2759
OrthoFinder	1	1.000	-	-		FOG0003492
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46174
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1383
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.900