DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3347 and Fbxl19

DIOPT Version :9

Sequence 1:	NP_001285579.1	Gene:	CG3347 / 33538	FlyBaseID:	FBgn0031513	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_036008913.1	Gene:	Fbxl19 / 233902	MGIID:	3039600	Length:	696	Species:	Mus musculus

Alignment Length:	436	Identity:	85/436 - (19%)
Similarity:	129/436 - (29%)	Gaps:	149/436 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GEADTAVSSKDVYCICRQSHINGFMICCDNCNEWFHGDCIGLPANIGE-QHDTYYCTECFRKNPL 74
            |:.||.....:.:.:.        ::.|..|||..|..|:.:....|. ..:...|.||
Mouse    97 GKEDTVEGEDEKFSLS--------LMECTICNEIVHPGCLKMGKAEGVINSEIPNCWEC------ 147

  Fly    75 LKCTYKKSPSTTGVPKTPKTPKTPKTPKNPKTPKTPKNSKTPKTARIINSIGVRQNPRRRSTFVQ 139
                                            |:..:..:|.|.|        .:.|.||
Mouse   148 --------------------------------PRCTQEGRTSKDA--------GEGPGRR----- 167

  Fly   140 ERPSEVPNPSRQSTKLQKAVNYENA---------TEEPTEDAEKVDQKPKKTAKKKNPKPEDKVT 195
                             :|.|.|..         ||||        ..|....::|.|.|.....
Mouse   168 -----------------RADNGEEGANLGGGWKLTEEP--------PPPPPLPRRKGPLPAGPTP 207

  Fly   196 DDAQKPAVEKLFESKGTQCNMFRDWSKYVPPENSKK-RGTCFTVFCQQLARSCSRYCCDECGNFT 259
            ||...|...|  |.:|..          .||...|| :|        ...|...:...|.|  ..
Mouse   208 DDVPGPPKRK--EREGGN----------EPPTPRKKVKG--------GRERHLKKVGGDAC--LL 250

  Fly   260 AITNVFALGLLPNM---PAMKVAMGHVGLLLGNDLTNNQKSNKNSEASESKTETKPKVKKPKSEG 321
            ...:..:.||||..   |:...:..|.||    ...|.:|......::|......|..::.|.|
Mouse   251 RGADPGSPGLLPPRVLNPSQAFSSCHPGL----PPENWEKPKPPIASAEGPAVPSPSPQREKLE- 310

  Fly   322 RKSRYRSPSSSLERSPDVSRTAAKRPKLQEELPSSSSRSSRKLVEE---SRSETERHKAKHKTSK 383
               |::.....|||.||.|.:::       :..|.|..|...|.|:   ..:...|..|:..:.:
Mouse   311 ---RFKRMCQLLERVPDTSSSSS-------DSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGE 365

  Fly   384 KEKTSSQRA-----------YSLSPIPSPKSYRAARNTSETAPNSP 418
            ||....:||           :.|.|.|.|:..:..|:.....|.||
Mouse   366 KENRGGRRAIRPGTGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSP 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3347	NP_001285579.1	PHD_SF	23..68	CDD:304600	8/45 (18%)
Fbxl19	XP_036008913.1	zf-CXXC	<52..79	CDD:366873
		PHD_FXL19	89..150	CDD:277115	14/98 (14%)
		F-box-like	426..467	CDD:403981
		AMN1	468..667	CDD:187754
		leucine-rich repeat	488..511	CDD:275381
		leucine-rich repeat	512..535	CDD:275381
		leucine-rich repeat	573..600	CDD:275381
		leucine-rich repeat	601..627	CDD:275381
		leucine-rich repeat	631..655	CDD:275381
		leucine-rich repeat	656..680	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1632
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900