DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hydr2 and abhd2b

DIOPT Version :9

Sequence 1:	NP_001245852.1	Gene:	Hydr2 / 33532	FlyBaseID:	FBgn0014906	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_001073145.1	Gene:	abhd2b / 559290	ZFINID:	ZDB-GENE-061027-74	Length:	422	Species:	Danio rerio

Alignment Length:	384	Identity:	152/384 - (39%)
Similarity:	237/384 - (61%)	Gaps:	3/384 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LTLIAVIVCILFRILNVHSQPLKPSVWCLDAHFLDCLYKIAPVLREPYIPPRLWGFSGHVQTVLH 70
            |..:|.::.::.|.||:........:.|.|......|.|..|||.:.||||.|||.|||:||.|:
Zfish    25 LAAVAAVLYVIVRSLNLKCPTAAADITCQDTLLNHYLLKSCPVLTKEYIPPLLWGKSGHLQTALY 89

  Fly    71 SIVGRVRCPWPLGERVYMSLKDGSTLTYDLYQP--LNEQEDDITVAICPGIANSSESVYIRTFVH 133
            ..:|||:.|.|.|.|.::.::||:|.|:||::|  ::...||||:.|||||.|.||..||||||.
Zfish    90 GKIGRVKSPKPCGLRKFLPMQDGATATFDLFEPQGVHSTGDDITMVICPGIGNHSEKHYIRTFVD 154

  Fly   134 LAQCNGYRCAVLNHIGALRSVQVTSTRIFTYGHTEDFAAMVEHLHQKYRQSRIVAVGFSLGGNLV 198
            .:|..|||||||||:|||.::::||.|:||||.|.:|:|||..:.:.:.|::::.||||||||:.
Zfish   155 YSQKQGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFSAMVGFIKRTFPQTQLIVVGFSLGGNIA 219

  Fly   199 TKYMGEDQKTKPDKVIGGISICQGYNAVEGTKWLLNWQNFRRFYLYIMTENVKSIILRHRHILLS 263
            .||:||:...: ::|:..:|:||||:|:...:..|.|...||.|.::|.:|:|.|||.||..|..
Zfish   220 CKYLGENPANQ-ERVLCCVSVCQGYSALRAQETFLQWDQCRRLYNFLMADNMKKIILSHRGSLFG 283

  Fly   264 DEVKARHNLNEREIIAAATLPELDEAYTRRVYNFPSTQELYKWSSSLFYFDTIKKPMIFINAKDD 328
            .........:...:..|.:|.::|:...|:.:...|.:|.|:..|.:.|...|..|::.:|:.||
Zfish   284 MNSSRMEFADLSRLYTATSLMQIDDNIMRKFHGHNSLKEYYEKESCVHYIHNISVPLLLVNSSDD 348

  Fly   329 PLIPEDLLHPIKEYATTRQNTAYVEVAHGGHLGFYEGGFLYPNPVTWLDRTLVAMVGSL 387
            ||:.:.||...:..|..:||..:....|||||||:||..|:|.|::|:|:.:|:...::
Zfish   349 PLVHQSLLTIPRTLAEKKQNVIFALTLHGGHLGFFEGAVLFPQPLSWMDKVIVSYANAV 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hydr2	NP_001245852.1	Abhydrolase	51..381	CDD:304388	139/331 (42%)
Hydr2	NP_001245852.1	Abhydrolase_1	115..365	CDD:278959	101/249 (41%)
abhd2b	NP_001073145.1	Abhydrolase	71..403	CDD:389770	140/332 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581979
Domainoid	1	1.000	220	1.000	Domainoid score	I2558
eggNOG	1	0.900	-	-		E1_COG0429
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2457
OMA	1	1.010	-	-		QHG53891
OrthoDB	1	1.010	-	-		D1033151at2759
OrthoFinder	1	1.000	-	-		FOG0006893
OrthoInspector	1	1.000	-	-		otm24355
orthoMCL	1	0.900	-	-		OOG6_106766
Panther	1	1.100	-	-	O	PTHR10794
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4462
SonicParanoid	1	1.000	-	-		X4995
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800