DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hydr2 and abhd2a

DIOPT Version :9

Sequence 1:	NP_001245852.1	Gene:	Hydr2 / 33532	FlyBaseID:	FBgn0014906	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_957208.1	Gene:	abhd2a / 393888	ZFINID:	ZDB-GENE-040426-784	Length:	432	Species:	Danio rerio

Alignment Length:	378	Identity:	159/378 - (42%)
Similarity:	240/378 - (63%)	Gaps:	4/378 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LTLIAVIVCILFRILNVHSQPLKPSVWCLDAHFLDCLYKIAPVLREPYIPPRLWGFSGHVQTVLH 70
            |..:|.::.::.|.||:.|....|.:...|......|.|..|:|.:.||||.|||.|||:||.|:
Zfish    24 LAAVATVLYVIVRCLNLKSPTAPPDLTFQDTTLNHFLLKSCPILTKEYIPPLLWGKSGHLQTALY 88

  Fly    71 SIVGRVRCPWPLGERVYMSLKDGSTLTYDLYQPLNEQE--DDITVAICPGIANSSESVYIRTFVH 133
            ..:|||..|.|.|.|.|:.::||:|.|:||::||.:.:  :|:|:.|||||.|.||..||||||.
Zfish    89 GKLGRVSSPHPFGLRKYLPMQDGATATFDLFEPLADHQSGEDVTMVICPGIGNHSEKHYIRTFVD 153

  Fly   134 LAQCNGYRCAVLNHIGALRSVQVTSTRIFTYGHTEDFAAMVEHLHQKYRQSRIVAVGFSLGGNLV 198
            .:|..|||||||||:|||.::::||.|:||||.|.:|||||..:.:.|.||:::.||||||||:|
Zfish   154 HSQKQGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFAAMVGFIKKTYPQSKLIVVGFSLGGNIV 218

  Fly   199 TKYMGEDQKTKPDKVIGGISICQGYNAVEGTKWLLNWQNFRRFYLYIMTENVKSIILRHRHILLS 263
            .|::||: :|..::|:..:|:||||:|:...:..|.|...||||.::|.:|:|.|||.||.:|..
Zfish   219 CKFLGEN-RTNQERVLCCVSVCQGYSALRAQETFLQWDQCRRFYNFLMADNMKKIILSHRGVLFG 282

  Fly   264 DEVKARHNLNEREIIAAATLPELDEAYTRRVYNFPSTQELYKWSSSLFYFDTIKKPMIFINAKDD 328
            ...|...:...| :..|.:|.::|:...|:.:...|.:|.|:..|.:.|...|..|::.:|:.||
Zfish   283 VGSKMVDSELSR-LYTATSLMQIDDNIMRKFHGHNSLKEYYEKESCVHYIHNINVPLLLVNSVDD 346

  Fly   329 PLIPEDLLHPIKEYATTRQNTAYVEVAHGGHLGFYEGGFLYPNPVTWLDRTLV 381
            ||:...||...:..|..::|..:....|||||||:||..|:|.|:||:|:.:|
Zfish   347 PLVHNSLLTIPRTLAEKKENVVFALTLHGGHLGFFEGAVLFPQPLTWMDKVIV 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hydr2	NP_001245852.1	Abhydrolase	51..381	CDD:304388	146/331 (44%)
Hydr2	NP_001245852.1	Abhydrolase_1	115..365	CDD:278959	107/249 (43%)
abhd2a	NP_957208.1	Abhydrolase	52..401	CDD:389770	152/350 (43%)
abhd2a	NP_957208.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..432
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581980
Domainoid	1	1.000	220	1.000	Domainoid score	I2558
eggNOG	1	0.900	-	-		E1_COG0429
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2457
OMA	1	1.010	-	-		QHG53891
OrthoDB	1	1.010	-	-		D1033151at2759
OrthoFinder	1	1.000	-	-		FOG0006893
OrthoInspector	1	1.000	-	-		otm24355
orthoMCL	1	0.900	-	-		OOG6_106766
Panther	1	1.100	-	-	LDO	PTHR10794
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4462
SonicParanoid	1	1.000	-	-		X4995
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800