DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hydr2 and ABHD15

DIOPT Version :9

Sequence 1:	NP_001245852.1	Gene:	Hydr2 / 33532	FlyBaseID:	FBgn0014906	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_937790.2	Gene:	ABHD15 / 116236	HGNCID:	26971	Length:	468	Species:	Homo sapiens

Alignment Length:	357	Identity:	84/357 - (23%)
Similarity:	130/357 - (36%)	Gaps:	57/357 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SVWCLDAHFLDCLYKIAPVLREPYIPPRLWGFSG-HVQTVLHSIVGRVRCPWPLGERVYMSLKDG 93
            |:.|..:....||.:...........||.| ||| |:||:.|.::  ...|.|...|.|:.|.|.
Human    71 SLVCKPSALAQCLLRALRRSEALEAGPRSW-FSGPHLQTLCHFVL--PVAPGPELAREYLQLADD 132

  Fly    94 STLTYD-LYQPLNEQEDDITVAICPGIANSSESVYIR-TFVHLAQC-----NGYRCAVLNHIGAL 151
            ..:..| :..|........:....|.:.....:.:.| |...|..|     .|| ..|:.|....
Human   133 GLVALDWVVGPCVRGRRITSAGGLPAVLLVIPNAWGRLTRNVLGLCLLALERGY-YPVIFHRRGH 196

  Fly   152 RSVQVTSTRIFTYGHTEDFAAMVEHLHQKYRQSRIVAVGFSLGGNLVTKYMGEDQKTKPDKVIGG 216
            ....:.|.|:..:|...|....|.::..::..:.:.||....|..|:..|:||         .|.
Human   197 HGCPLVSPRLQPFGDPSDLKEAVTYIRFRHPAAPLFAVSEGSGSALLLSYLGE---------CGS 252

  Fly   217 ISICQGYNAVEGT----KWL---LNWQNFRRFYLYIMTENVKSIILRHRHILLSDEVKA-RHNLN 273
            .|...|...:...    :|.   |.|...|.|.|             |:.|.||....| ...::
Human   253 SSYVTGAACISPVLRCREWFEAGLPWPYERGFLL-------------HQKIALSRYATALEDTVD 304

  Fly   274 EREIIAAATLPELDEAYTRRVYNFPSTQELYKW--SSSLFYFDTIKKPMIFINAKDDPLI-PEDL 335
            ...:..:.:|.|.:||......:||.:.:.| |  :..|...|....|::.|.:.|||:. |.|
Human   305 TSRLFRSRSLREFEEALFCHTKSFPISWDTY-WDRNDPLRDVDEAAVPVLCICSADDPVCGPPD- 367

  Fly   336 LHPIKEYATTR--QNTAYVEV---AHGGHLGF 362
             |.:    ||.  .:..|..:   .||||.||
Human   368 -HTL----TTELFHSNPYFFLLLSRHGGHCGF 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hydr2	NP_001245852.1	Abhydrolase	51..381	CDD:304388	80/336 (24%)
Hydr2	NP_001245852.1	Abhydrolase_1	115..365	CDD:278959	62/270 (23%)
ABHD15	NP_937790.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..61
ABHD15	NP_937790.2	Abhydrolase	100..419	CDD:304388	78/328 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0429
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53891
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820