Protein Alignment gkt and TDP1

DIOPT Version :10

• Sequence 1: NP_523465.2
• Gene: gkt / 33530
• FlyBaseID: FBgn0260817
• Length: 580
• Species: Drosophila melanogaster
• Sequence 2: NP_009782.3
• Gene: TDP1 / 852525
• SGDID: S000000427
• Length: 544
• Species: Saccharomyces cerevisiae
• Alignment Length: 613
• Identity: 122/613 - (19%)
• Similarity: 215/613 - (35%)
• Gaps: 207/613 - (33%)

  Fly    94 SLDTNPSGSSASGPAASQDTSNLAKKQKLNAKNIRDYIPVVIEKGGMAKKLERAAPYNMFLTAIT 158
            |.:||.:|:       .:..|::|:|.....|::|           .:.::|..||.|    :..
Yeast     2 SRETNFNGT-------KRKRSDVAEKVAQRWKSVR-----------YSAEMENMAPVN----SNN 44

  Fly   159 DSKP----THSEPLSITLQE--------------------------ILDESLGEIESTVQI---- 189
            ||..    :.|:.:.:|.||                          ..::.:||:|..:.:
Yeast    45 DSDDCVIVSESKIIDLTNQEQDLSERIETNDTAKGAVFKLMKSDFYEREDFMGEVEDMITLKDIF 109

  Fly   190 -----------NFMVDIGWLLGHYY------------------FAGILDKPLLLLYGDESPELLS 225
                       :|..::.:||..::                  .|..:|..|.::.
Yeast   110 GTETLKRSILFSFQYELDFLLRQFHQNVENITIVGQKGTIMPIEARAMDATLAVIL--------- 165

  Fly   226 IGKFKQQVTAIRVKMPTPFATSHTKMMFLGYSDGSMRVVISTANLYEDDWHNRTQGLWISPKL-- 288
                 ::|..|.:.|| |||:.|||::...|.:|..::.:.:.|....:.:...|..|.||.|
Yeast   166 -----KKVKLIEITMP-PFASHHTKLIINFYDNGECKIFLPSNNFTSMETNLPQQVCWCSPLLKI 224

  Fly   289 --PALPVDADTGAGESLTGFKQDLMLYLVEYKISQLQPWIAR-IRNSDFSAIN-VFFLGSVPGGH 349
              ..|||.           ||:.|:.||..|.:..:...|.: :...:|:.:: :.|:.|.|...
Yeast   225 GKEGLPVP-----------FKRSLIEYLNSYHLKDIDELITKSVEEVNFAPLSELEFVYSTPSKF 278

  Fly   350 REGSVRGHPWGHARLASLLAKHAAPIDDRIPVVCQSSSIG---SLGANVQAWIQ----------- 400
            :...:...   :.:|..|.|..:|. |.....:||:||||   |...:...|..
Yeast   279 QSSGLLSF---YNKLEKLSAGTSAS-DTAKHYLCQTSSIGTSLSRARDENLWTHLMIPLFTGIMS 339

  Fly   401 ---QDFVNSLKKDSTPVGKL------RQMPPFKMIYPSYGNVAGSHDGMLGGGCLPYGKNTNDKQ 456
               :|.....|.:..|...|      |::.|: :|:|:......|.......|
Yeast   340 PPAKDTAGRKKAEILPTNSLINEYSQRKIKPY-IIFPTEQEFVTSPLKWSSSG------------ 391

  Fly   457 PWLK-DYLQQWKSSDRFRSR---------AM---------PHIKSYTRFNLED----------QS 492
             |.. .|||:....:..|::         ||         .|.|.|.......          :.
Yeast   392 -WFHFQYLQKKSYYEMLRNKFKVFYKQDPAMVTRRRGTTPAHSKFYMHCATNSAGPCDASQVFKE 455

  Fly   493 VYWFVLTSANLSKAAWGCFNKNSNIQPCLRIANYEAGVLFLPRFVTGE-----DTFPLGNNRDGV 552
            :.|.:.||||||:.|||..::...        |||||||:..|.:...     .||.  .:|.|.
Yeast   456 LEWCLYTSANLSQTAWGTVSRKPR--------NYEAGVLYHSRRLANTRKVTCRTFT--RDRRGC 510

  Fly   553 PAFP----LPYDVPLTPY-APDDKPFLM 575
            ...|    :|:.:|:.|| ..:|:.|.:
Yeast   511 AGNPTHVAVPFTLPVIPYDLAEDECFCL 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gkt	NP_523465.2	zf-CCHH	3..25	CDD:463043
		Tyr-DNA_phospho	152..567	CDD:461824	107/545 (20%)
TDP1	NP_009782.3	Tyr-DNA_phospho	83..529	CDD:461824	100/499 (20%)