DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gkt and tdp1

DIOPT Version :9

Sequence 1:	NP_523465.2	Gene:	gkt / 33530	FlyBaseID:	FBgn0260817	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	XP_700174.2	Gene:	tdp1 / 571485	ZFINID:	ZDB-GENE-090909-1	Length:	615	Species:	Danio rerio

Alignment Length:	577	Identity:	192/577 - (33%)
Similarity:	287/577 - (49%)	Gaps:	69/577 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 TQLKLLEKLFPKQATNK-------------EQEAHSSSSKP------AVTAPVASGSSSSGSLDT 97
            |.||...:|.||:..|.             .:.||.:.:.|      |..|......:..|..:.
Zfish    47 TFLKQEPRLSPKRNENSVKTASAPSMGSEARKSAHVNQANPVKYERNASPAVKRKRETEEGGWNL 111

  Fly    98 NPSGSSASGPAASQDTSNLAKKQKLNAKNIRDYIPVVIEKGGMAKKLERAAP------------Y 150
            :.|......|.......|::.|:|...::.|...|     .|.:...|..|.            |
Zfish   112 SSSDDETPAPRNEPQKVNISPKRKKKTEDKRPPSP-----HGTSYYKEEPADFFETNLMPTNDIY 171

  Fly   151 NMFLTAITDSKPTHSEPLSITLQEILDESLGEIESTVQINFMVDIGWLLGHYYFAGILDKPLLLL 215
            ..:|..:| ..|......::.::|||....|.::.:||.|:..||.|:: ..|.....:||::|:
Zfish   172 RFYLNKVT-GIPKKYNTGALHIKEILSPMFGTLKESVQFNYCFDIPWMV-EQYPPEFRNKPVVLV 234

  Fly   216 YGDESPE---LLSIGKFKQQVTAIRVKMPTPFATSHTKMMFLGYSDGSMRVVISTANLYEDDWHN 277
            :|::...   |:...|....::..:.|:...|.|.|||||.|.|.:| .||:|.|:||...||:.
Zfish   235 HGEKRESKACLIEQAKPYPHISFCQAKLDIAFGTHHTKMMLLWYEEG-FRVIILTSNLIRADWYQ 298

  Fly   278 RTQGLWISPKLPALPVDADTGAGESLTGFKQDLMLYLVEYKISQLQPWIARIRNSDFSAINVFFL 342
            :|||:|:||..|.||..:...|||||||||:||:.||..|:..:|..||.||:..|.|...|:.:
Zfish   299 KTQGMWMSPLYPRLPQGSPGTAGESLTGFKRDLLEYLEAYRAPELANWIERIKQHDLSETRVYLI 363

  Fly   343 GSVPGGHREGSVRGHPWGHARLASLLAKHAAPI--DDRIPVVCQSSSIGSLGANVQAWIQQDFVN 405
            ||.||.::..::  ..|||.||..||::|..|:  ::|..|:.|.|||||:|.:...|:..:|..
Zfish   364 GSTPGRYQGPAM--EKWGHLRLRKLLSEHTQPMQNEERWHVLGQFSSIGSMGLDKTKWLAAEFQR 426

  Fly   406 SLKKDSTPVGKLRQ---MPPFKM--IYPSYGNVAGSHDGMLGGGCLPYGKNTNDKQPWLKDYLQQ 465
            :|    |.:||..:   .|..:|  ||||..||..|.:|...||.|||...|..||.||..|...
Zfish   427 TL----TTLGKAGKSLASPETQMLLIYPSVENVRTSLEGYPAGGSLPYSIQTAQKQLWLHSYFHG 487

  Fly   466 WKSSDRFRSRAMPHIKSYTRFNLEDQSVYWFVLTSANLSKAAWGCFNKNSNIQPCLRIANYEAGV 530
            |.:....||.||||||:|.|.:.:...:.||::|||||||||||...|| |.|  :.:.:||.||
Zfish   488 WHADVTGRSNAMPHIKTYMRISPDFTQLAWFLVTSANLSKAAWGALEKN-NTQ--IMVRSYELGV 549

  Fly   531 LFLP------RFVTGEDTFPLGNNRDGVPAFPLPYDVPLTPYAPDDKPFL--MDYLQ 579
            |:||      .|...::.||..::..|   ||:|:|:|...|:..|:|::  :.|.|
Zfish   550 LYLPSAFNMSTFPVEKNVFPACSSSIG---FPVPFDLPPQRYSSKDRPWIWNIPYTQ 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gkt	NP_523465.2	zf-CCHH	2..23	CDD:287283
		PLDc_mTdp1_1	149..317	CDD:197289	62/182 (34%)
		Tyr-DNA_phospho	153..567	CDD:283694	163/429 (38%)
		PLDc_mTdp1_2	339..534	CDD:197291	83/201 (41%)
tdp1	XP_700174.2	PLDc_mTdp1_1	171..338	CDD:197289	62/169 (37%)
		Tyr-DNA_phospho	172..589	CDD:283694	163/431 (38%)
		PLDc_mTdp1_2	360..553	CDD:197291	83/201 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595519
Domainoid	1	1.000	270	1.000	Domainoid score	I1780
eggNOG	1	0.900	-	-		E1_KOG2031
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5424
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2885
OMA	1	1.010	-	-		QHG58389
OrthoDB	1	1.010	-	-		D1295967at2759
OrthoFinder	1	1.000	-	-		FOG0003245
OrthoInspector	1	1.000	-	-		oto40068
orthoMCL	1	0.900	-	-		OOG6_101894
Panther	1	1.100	-	-	LDO	PTHR12415
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3767
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770