DRSC/TRiP Functional Genomics Resources

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Protein Alignment gkt and TDP1

DIOPT Version :9

Sequence 1:NP_523465.2 Gene:gkt / 33530 FlyBaseID:FBgn0260817 Length:580 Species:Drosophila melanogaster
Sequence 2:XP_024305417.1 Gene:TDP1 / 55775 HGNCID:18884 Length:650 Species:Homo sapiens


Alignment Length:629 Identity:201/629 - (31%)
Similarity:290/629 - (46%) Gaps:103/629 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 CPYGEKCYRKNPIHFGEFSHAHLDAIY-AKGNESGDYE-IPANYSSEMIHTQLKLLEKLFPKQAT 66
            |...:|...|..|...:||:.  |::. .|..:||..| :....||.....|.::.:|...|...
Human    48 CSEAQKAAHKRKISPVKFSNT--DSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVI 110

  Fly    67 NKEQEAHSSSSKPAVTAPVASGSSSSGSLDTNPSGSSASGPAASQDTSNLAKKQKLNAKNIRDYI 131
            .||::.                              ||.....:|.|.|.........|...|..
Human   111 KKEKDI------------------------------SAPNDGTAQRTENHGAPACHRLKEEEDEY 145

  Fly   132 PVVIEKGGMAKKLERAAPYNMFLTAITDSKPTHSEPLSITLQEILDESLGEIESTVQINFMVDIG 196
            ....|...:...|::..|:..:||.::..||.::.. ::.:::||....|.:.|:.|.|:..|:.
Human   146 ETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNSG-ALHIKDILSPLFGTLVSSAQFNYCFDVD 209

  Fly   197 WLLGHYYFAGILDKPLLLLYGDE---SPELLSIGKFKQQVTAIRVKMPTPFATSHTKMMFLGYSD 258
            ||:..|. .....||:||::||:   ...|.:..|..:.::..:.|:...|.|.|||||.|.|.:
Human   210 WLVKQYP-PEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEE 273

  Fly   259 GSMRVVISTANLYEDDWHNRTQGLWISPKLPALPVDADTGAGESLTGFKQDLMLYLVEYKISQLQ 323
            | :||||.|:||...|||.:|||:|:||..|.: .|....:|||.|.||.||:.||:.|....|:
Human   274 G-LRVVIHTSNLIHADWHQKTQGIWLSPLYPRI-ADGTHKSGESPTHFKADLISYLMAYNAPSLK 336

  Fly   324 PWIARIRNSDFSAINVFFLGSVPGGHREGSVRGHPWGHARLASLLAKHAA--PIDDRIPVVCQSS 386
            .||..|...|.|..||:.:||.| |..:||.:.: |||.||..||..||:  |..:..|||.|.|
Human   337 EWIDVIHKHDLSETNVYLIGSTP-GRFQGSQKDN-WGHFRLKKLLKDHASSMPNAESWPVVGQFS 399

  Fly   387 SIGSLGANVQAWIQQDFVNSL----KKDSTPVGKLRQMPPFKMIYPSYGNVAGSHDGMLGGGCLP 447
            |:|||||:...|:..:|..|:    |:..|| ||  ...|..:||||..||..|.:|...||.||
Human   400 SVGSLGADESKWLCSEFKESMLTLGKESKTP-GK--SSVPLYLIYPSVENVRTSLEGYPAGGSLP 461

  Fly   448 YGKNTNDKQPWLKDYLQQWKSSDRFRSRAMPHIKSYTRFNLEDQSVYWFVLT------------- 499
            |...|.:||.||..|..:|.:....||.||||||:|.|.:.:...:.||::|             
Human   462 YSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTRWSCFALIAQAGV 526

  Fly   500 -----------------------------SANLSKAAWGCFNKNSNIQPCLRIANYEAGVLFLPR 535
                                         ||||||||||...||..   .|.|.:||.||||||.
Human   527 QWLHLAPQQPPPPGFKRFSCLSLLSSWDYSANLSKAAWGALEKNGT---QLMIRSYELGVLFLPS 588

  Fly   536 FVTGEDTFPL-----GNNRDGVPAFPLPYDVPLTPYAPDDKPFL 574
             ..|.|:|.:     ..:::.:..||:|||:|...|...|:|::
Human   589 -AFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSKDRPWI 631

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gktNP_523465.2 zf-CCHH 2..23 CDD:287283 5/18 (28%)
PLDc_mTdp1_1 149..317 CDD:197289 62/170 (36%)
Tyr-DNA_phospho 153..567 CDD:283694 170/469 (36%)
PLDc_mTdp1_2 339..534 CDD:197291 90/242 (37%)
TDP1XP_024305417.1 Tyr-DNA_phospho 166..624 CDD:310580 170/470 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159367
Domainoid 1 1.000 280 1.000 Domainoid score I1694
eggNOG 1 0.900 - - E1_KOG2031
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H5424
Inparanoid 1 1.050 293 1.000 Inparanoid score I2782
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG58389
OrthoDB 1 1.010 - - D1295967at2759
OrthoFinder 1 1.000 - - FOG0003245
OrthoInspector 1 1.000 - - oto91329
orthoMCL 1 0.900 - - OOG6_101894
Panther 1 1.100 - - LDO PTHR12415
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1570
SonicParanoid 1 1.000 - - X3767
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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