DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gkt and Tdp1

DIOPT Version :9

Sequence 1:	NP_523465.2	Gene:	gkt / 33530	FlyBaseID:	FBgn0260817	Length:	580	Species:	Drosophila melanogaster
Sequence 2:	XP_030102366.1	Gene:	Tdp1 / 104884	MGIID:	1920036	Length:	672	Species:	Mus musculus

Alignment Length:	603	Identity:	203/603 - (33%)
Similarity:	292/603 - (48%)	Gaps:	84/603 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CPYGEKCYRKNPIHFGEFSHAHLDAIYAKGNESGDYEIPANY--SSEMIHTQLKLLEKLFPKQAT 66
            |....|...|..|...:|:.|  |::.....:..|......:  ||.....|..:.::..||:..
Mouse    52 CSEARKVAHKRQISPVKFNDA--DSVLPHKKQKSDSPEGLGWCLSSSDDDQQPDVTQQEQPKRVL 114

  Fly    67 NKEQEAHSSSSKPAVTAPVASGSSSSGSLDTNPSGSSASGPAASQ-DTSNLAKKQKLNAKNIRDY 130
            .:|:: |.||  |.||       ::...:|.:|..|.....|..: :||.       ..::|.|
Mouse   115 PQEKK-HVSS--PDVT-------TAQKVVDRSPPASLRPQRADDEYETSG-------EGQDIWD- 161

  Fly   131 IPVVIEKGGMAKKLERAAPYNMFLTAITDSKPTHSEPLSITLQEILDESLGEIESTVQINFMVDI 195
               :::||.         |:..:||.::..|..::.. ::.:::||....|.:.|:.|.|:..|:
Mouse   162 ---MLDKGN---------PFQFYLTRVSGIKAKYNSK-ALHIKDILSPLFGTLVSSAQFNYCFDV 213

  Fly   196 GWLLGHYYFAGILDKPLLLLYGDE---SPELLSIGKFKQQVTAIRVKMPTPFATSHTKMMFLGYS 257
            .||:..|. ......|:||::||:   ..:|.:..|....::..:.|:...|.|.|||||.|.|.
Mouse   214 DWLIKQYP-PEFRKNPILLVHGDKREAKADLHAQAKPYANISLCQAKLDIAFGTHHTKMMLLLYE 277

  Fly   258 DGSMRVVISTANLYEDDWHNRTQGLWISPKLPALPVDADTGAGESLTGFKQDLMLYLVEYKISQL 322
            :| :||||.|:||..:|||.:|||:|:||..|.:...:.| ||||.|.||.||..||..|....|
Mouse   278 EG-LRVVIHTSNLIREDWHQKTQGIWLSPLYPRIDQGSHT-AGESSTRFKADLTSYLTAYNAPPL 340

  Fly   323 QPWIARIRNSDFSAINVFFLGSVPGGHREGSVRGHPWGHARLASLLAKHA--APIDDRIPVVCQS 385
            |.||..|:..|.|..||:.:||.| |..:||.|.: |||.||..||..||  .|..:..|:|.|.
Mouse   341 QEWIDIIQEHDLSETNVYLIGSTP-GRFQGSHRDN-WGHFRLRKLLQAHAPSTPKGECWPIVGQF 403

  Fly   386 SSIGSLGANVQAWIQQDFVNS---LKKDSTPVGKLRQMPPFKMIYPSYGNVAGSHDGMLGGGCLP 447
            |||||||.:...|:..:|.:|   |:::..|.||  ...|..:||||..||..|.:|...||.||
Mouse   404 SSIGSLGPDESKWLCSEFKDSLLALREEGRPPGK--SAVPLHLIYPSVENVRTSLEGYPAGGSLP 466

  Fly   448 YGKNTNDKQPWLKDYLQQWKSSDRFRSRAMPHIKSYTRFNLEDQSVYWFVLTSANLSKAAWGCFN 512
            |...|.:||.||..|..:|.:....||.||||||:|.|.:.:...:.||::|||||||||||...
Mouse   467 YSIQTAEKQRWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKLAWFLVTSANLSKAAWGALE 531

  Fly   513 KNSNIQPCLRIANYEAGVLFLPR------------FVTGED-------TFPLGNNRDGVPAFPLP 558
            ||..   .|.|.:||.||||||.            |..|..       .||.|::...:||.
Mouse   532 KNGT---QLMIRSYELGVLFLPSAFSSPVLLHPRGFQDGTAGRYLQLLLFPTGHSGRSMPAV--- 590

  Fly   559 YDVPLTP--------YAP 568
            ...||.|        :||
Mouse   591 LHQPLLPSLGLLSSGFAP 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gkt	NP_523465.2	zf-CCHH	2..23	CDD:287283	5/18 (28%)
		PLDc_mTdp1_1	149..317	CDD:197289	61/170 (36%)
		Tyr-DNA_phospho	153..567	CDD:283694	170/448 (38%)
		PLDc_mTdp1_2	339..534	CDD:197291	89/199 (45%)
Tdp1	XP_030102366.1	Tyr-DNA_phospho	171..554	CDD:368738	160/393 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849737
Domainoid	1	1.000	279	1.000	Domainoid score	I1686
eggNOG	1	0.900	-	-		E1_KOG2031
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5424
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2784
Isobase	1	0.950	-	0	Normalized mean entropy	S4056
OMA	1	1.010	-	-		QHG58389
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003245
OrthoInspector	1	1.000	-	-		oto94908
orthoMCL	1	0.900	-	-		OOG6_101894
Panther	1	1.100	-	-	LDO	PTHR12415
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1570
SonicParanoid	1	1.000	-	-		X3767
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740