DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mad and Smad9

DIOPT Version :9

Sequence 1:	NP_001259992.1	Gene:	Mad / 33529	FlyBaseID:	FBgn0011648	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_620227.2	Gene:	Smad9 / 85435	RGDID:	71004	Length:	430	Species:	Rattus norvegicus

Alignment Length:	445	Identity:	329/445 - (73%)
Similarity:	363/445 - (81%)	Gaps:	27/445 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 LGSLFSFTSPAVKKLLGWKQGDEEEKWAEKAVDSLVKKLKKRKGAIEELERALSCPGQPSKCVTI 151
            :.|||||||||||:|||||||||||||||||||||||||||:|||::||||||||||||||||||
  Rat     7 ISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPGQPSKCVTI 71

  Fly   152 PRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYKRVES 216
            ||||||||||||||||||||||||||||||||||||||||.|::||.:||||||||||||:|||:
  Rat    72 PRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVET 136

  Fly   217 PVLPPVLVPRHSEFAPGHSML-QFNHV---AEPSMPHNVSYSNSGFNSHSLSTSNTSVGSPSSVN 277
            |||||||||||||:.|..|:| :|...   :||.||||.:|.:|  ...||..:..|  ||..|
  Rat   137 PVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDS--FQQSLGPAPPS--SPGHV- 196

  Fly   278 SNPNSPYDSLAGTPPPAY--SPSEDGNSNNPNDGGQLLDAQMGDVAQVSYSEPAFWASIAYYELN 340
             .|.||.       |.:|  ||.....|::|        .|..|...|.|.||..|.|:||||||
  Rat   197 -FPQSPC-------PTSYPQSPGSPSESDSP--------YQHSDFRPVCYEEPLHWCSVAYYELN 245

  Fly   341 CRVGEVFHCNNNSVIVDGFTNPSNNSDRCCLGQLSNVNRNSTIENTRRHIGKGVHLYYVTGEVYA 405
            .||||.|..::.||::||||:||||.:|.|||.||||||||||||||||||||||||||.|||||
  Rat   246 NRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYA 310

  Fly   406 ECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIFNNQEFAQLLSQSVNNGFEAVYELTKMC 470
            ||:|||:||||||||||.|||||:||||||.|||||:||||.|||||:|||::|||.||||||||
  Rat   311 ECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMC 375

  Fly   471 TIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNAISSVS 525
            |||||||||||||||||||||||||||||||||||||||||||||||||.|||||
  Rat   376 TIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	112/122 (92%)
Mad	NP_001259992.1	MH2_SMAD_1_5_9	325..525	CDD:199822	167/199 (84%)
Smad9	NP_620227.2	MH1_SMAD_1_5_9	13..136	CDD:199814	112/122 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..222		21/71 (30%)
		MH2	230..430	CDD:412135	167/199 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	322	1.000	Domainoid score	I1179
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	701	1.000	Inparanoid score	I638
OMA	1	1.010	-	-		QHG48637
OrthoDB	1	1.010	-	-		D274383at33208
OrthoFinder	1	1.000	-	-		FOG0000630
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103959
Panther	1	1.100	-	-	O	PTHR13703
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X373
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.980