DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mad and Smad7

DIOPT Version :9

Sequence 1:	NP_001259992.1	Gene:	Mad / 33529	FlyBaseID:	FBgn0011648	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_110485.1	Gene:	Smad7 / 81516	RGDID:	69314	Length:	426	Species:	Rattus norvegicus

Alignment Length:	403	Identity:	112/403 - (27%)
Similarity:	171/403 - (42%)	Gaps:	103/403 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 SLVKKLKKRKGAIEELERAL-SCPGQPSKCVTIPRSLDGRL-----------QVSHRKGLPHVIY 172
            |::||||:|:  :|.|.:|: |..|..:.|:.:|..||.||           |......|| ::.
  Rat    98 SVLKKLKERQ--LELLLQAVESRGGTRTACLLLPGRLDCRLGPGAPASAQPAQPPSSYSLP-LLL 159

  Fly   173 CRVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYKRVESPVLPPVLVPRHSEFAPGHSML 237
            |:|:|||||:...|:|.|..|:.......:.||.||:|..|:.....||   |.:|.:
  Rat   160 CKVFRWPDLRHSSEVKRLCCCESYGKINPELVCCNPHHLSRLCELESPP---PPYSRY------- 214

  Fly   238 QFNHVAEPSMPHNVSYSNSGFNSHSLSTSNTSVGSPSSVNSNPNSPYDSL---AGTPPPAYSPSE 299
                                                         |.|.|   |..|....|..|
  Rat   215 ---------------------------------------------PMDFLKPTADCPDAVPSSDE 234

  Fly   300 DGNSNNPNDGGQLLDAQM----GDVAQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIVDGFT 360
            .|.:|....|| |.|:|:    ||        .:.|..:||:|...|||.::.....|  :|.|.
  Rat   235 TGGTNYLAPGG-LSDSQLLLEPGD--------RSHWCVVAYWEEKTRVGRLYCVQEPS--LDIFY 288

  Fly   361 N-PSNNSDRCCLGQLSNVNRNSTIENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHH 424
            : |..|.  .|||||::.|::..::..|..||.|:.|......|:....|...||::|...:
  Rat   289 DLPQGNG--FCLGQLNSDNKSQLVQKVRSKIGCGIQLTREVDGVWVYNRSSYPIFIKSATLD--- 348

  Fly   425 GFHPST----VCKIPPGCSLKIFNNQEFAQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYH 485
              :|.:    |.|:.||.|:|.|   ::.:..|....|..|.:.:.....|:::|||||||..|.
  Rat   349 --NPDSRTLLVHKVFPGFSIKAF---DYEKAYSLQRPNDHEFMQQPWTGFTVQISFVKGWGQCYT 408

  Fly   486 RQDVTSTPCWIEI 498
            ||.::|.|||:|:
  Rat   409 RQFISSCPCWLEV 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	37/107 (35%)
Mad	NP_001259992.1	MH2_SMAD_1_5_9	325..525	CDD:199822	55/179 (31%)
Smad7	NP_110485.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..40
		MH1_SMAD_7	60..205	CDD:199818	37/109 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..88
		Important for interaction with SMURF2. /evidence=ECO:0000250	208..217		4/63 (6%)
		PY-motif. /evidence=ECO:0000250	208..211		2/5 (40%)
		MH2_SMAD_7	254..424	CDD:199825	57/188 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810