DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mad and smad6b

DIOPT Version :9

Sequence 1:	NP_001259992.1	Gene:	Mad / 33529	FlyBaseID:	FBgn0011648	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001038516.1	Gene:	smad6b / 564395	ZFINID:	ZDB-GENE-050419-198	Length:	486	Species:	Danio rerio

Alignment Length:	518	Identity:	134/518 - (25%)
Similarity:	218/518 - (42%)	Gaps:	110/518 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TGYR-VTP---PQINGGTTTTTTISSGSSNNNNIHHINNNNNHICSSGSSNNL------NLTTAI 64
            |.:| :||   |.::.|...|...:..|....:...::.:...:|:.||..::      .:|..:
Zfish    50 TEFRPMTPSGSPSVDYGEVCTRNPAESSGGGTSGGFLDQDGGTVCTVGSPRSVQDSDCRTVTCCL 114

  Fly    65 -------SGSSNRMDTDDVESNTSSAMSTLGSLFSFTSPAVKKLLGWKQGDEEEKWAEKAVDSLV 122
                   |||.:        ....|....|.::.|...|...:....|.....|:..:.|..||:
Zfish   115 FKDRDHHSGSRS--------PEPGSCQFVLRNIGSSRDPGPLESQESKPRSVMEQELKTATYSLL 171

  Fly   123 KKLKKRKGAIEELERALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHEL 187
            |:||::  .::.|..|:...|.||.||.:.|:   .|::......|.::.|:::||.|||...:|
Zfish   172 KRLKEK--TLDTLLEAVESGGMPSDCVMVSRT---ELRLGGHMAPPQLLICKLYRWSDLQHTAQL 231

  Fly   188 KPLELCQYPFSAKQ-KEVCINPYHYKRVESPVLPPVLVPRHSEFAPGHSMLQFNHVAEPSMPHNV 251
            |.|..|: .|.|:. ..||.|||||.|:..|..||   |.:|..:|          :|...|.::
Zfish   232 KALCECK-SFGAQDGPVVCCNPYHYSRLCGPESPP---PPYSRLSP----------SEEHKPLDL 282

  Fly   252 SYSNSGF-NSHSLSTSNTSVGSPSSVNSNPNSPYDSLAGTPPPAYSPSEDGNSNNPNDGGQLLDA 315
            |.|...: .:.:.|:.|.:.|..|..:.:|::|..|
Zfish   283 SDSTLSYTETEAASSPNATQGEFSDASLSPDAPKQS----------------------------- 318

  Fly   316 QMGDVAQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIV-------DGFTNPSNNSDRCCLGQ 373
                          .|.::||:|...|||.::.....:|.:       .||          ||||
Zfish   319 --------------HWCNVAYWEHRTRVGRLYTVYQPAVSIFYDLPQGTGF----------CLGQ 359

  Fly   374 LSNVNRNSTIENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGC 438
            ||...|:||::.||..||.|:.|......|:|...|...|||.|...:. .|.....|.|:.||.
Zfish   360 LSLDQRSSTVQRTRGKIGYGLLLSKEPDGVWAYNRSQHPIFVNSPTLDV-PGSRSLVVRKVMPGY 423

  Fly   439 SLKIFNNQEFAQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLH 501
            |:|:|:.:..:.|...:.:...:..|:..   ::|:||.||||..|.||.:||.|||:||.|:
Zfish   424 SIKVFDYERSSMLRQGAESELLDGPYDPN---SVRISFAKGWGPCYSRQFITSCPCWLEILLN 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	39/123 (32%)
Mad	NP_001259992.1	MH2_SMAD_1_5_9	325..525	CDD:199822	60/184 (33%)
smad6b	NP_001038516.1	MH1_SMAD_6	152..262	CDD:199817	38/115 (33%)
smad6b	NP_001038516.1	MH2_SMAD_6	311..484	CDD:199824	63/230 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810