DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mad and smad9

DIOPT Version :9

Sequence 1:	NP_001259992.1	Gene:	Mad / 33529	FlyBaseID:	FBgn0011648	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001007479.1	Gene:	smad9 / 493210	XenbaseID:	XB-GENE-484686	Length:	466	Species:	Xenopus tropicalis

Alignment Length:	466	Identity:	344/466 - (73%)
Similarity:	376/466 - (80%)	Gaps:	25/466 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 AMSTLGSLFSFTSPAVKKLLGWKQGDEEEKWAEKAVDSLVKKLKKRKGAIEELERALSCPGQPSK 147
            |.:.:.|||||||||||:|||||||||||||||||||||||||||:|||:|||||||||||||||
Frog     3 ASTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMEELERALSCPGQPSK 67

  Fly   148 CVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYK 212
            ||||||||||||||||||||||||||||||||||||||||||:|.|::||.:|||:||||||||:
Frog    68 CVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPMECCEFPFGSKQKDVCINPYHYR 132

  Fly   213 RVESPVLPPVLVPRHSEFAPGHSML-QFNHVA---EPSMPHNVSYSNSGFNSH------SLSTSN 267
            |||:||||||||||||||.|..|:| :|.:.:   ||.||||.::..| |...      |.|.||
Frog   133 RVETPVLPPVLVPRHSEFNPQLSLLAKFRNTSLNNEPLMPHNATFPES-FQQQPPCTPFSSSPSN 196

  Fly   268 ------TSVGSPSSVNS--NPNSPYDSLAGTPPPAY-SPSEDGNSNNPNDGGQ----LLDAQMGD 319
                  |:||.|.|..|  :|.||| .:..||||.| :|...||.|.|.....    :|.|...|
Frog   197 IFPQSPTTVGYPDSPQSSADPGSPY-QITETPPPPYNAPDIQGNQNRPTADPAACQLVLSALNRD 260

  Fly   320 VAQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIVDGFTNPSNNSDRCCLGQLSNVNRNSTIE 384
            ...|.|.||..|.|:||||||.||||.|..::.||::||||:||||.:|.|||.|||||||||||
Frog   261 FRPVCYEEPLHWCSVAYYELNNRVGETFQASSRSVLIDGFTDPSNNKNRFCLGLLSNVNRNSTIE 325

  Fly   385 NTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIFNNQEFA 449
            |||||||||||||||.|||||||:|||:||||||||||.||||||||||||.||||||||||.||
Frog   326 NTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPSTVCKIPSGCSLKIFNNQLFA 390

  Fly   450 QLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQM 514
            ||||||||.|||.||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   391 QLLSQSVNQGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQM 455

  Fly   515 GSPHNAISSVS 525
            |||||.|||||
Frog   456 GSPHNPISSVS 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	111/122 (91%)
Mad	NP_001259992.1	MH2_SMAD_1_5_9	325..525	CDD:199822	171/199 (86%)
smad9	NP_001007479.1	MH1_SMAD_1_5_9	13..136	CDD:199814	111/122 (91%)
		PRK10263	<137..>249	CDD:236669	50/113 (44%)
		MH2_SMAD_1_5_9	266..466	CDD:199822	171/199 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	324	1.000	Domainoid score	I1201
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	704	1.000	Inparanoid score	I648
OMA	1	1.010	-	-		QHG48637
OrthoDB	1	1.010	-	-		D274383at33208
OrthoFinder	1	1.000	-	-		FOG0000630
OrthoInspector	1	1.000	-	-		otm47704
Panther	1	1.100	-	-	O	PTHR13703
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2797
SonicParanoid	1	1.000	-	-		X373
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110