DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mad and smad9

DIOPT Version :9

Sequence 1:	NP_001259992.1	Gene:	Mad / 33529	FlyBaseID:	FBgn0011648	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001315428.1	Gene:	smad9 / 445564	ZFINID:	ZDB-GENE-031014-1	Length:	466	Species:	Danio rerio

Alignment Length:	472	Identity:	343/472 - (72%)
Similarity:	382/472 - (80%)	Gaps:	28/472 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 VESNTSSAMSTLGSLFSFTSPAVKKLLGWKQGDEEEKWAEKAVDSLVKKLKKRKGAIEELERALS 140
            :.|:||     :.|||||||||||:|||||||||||||||||||||||||||:|||:||||:|||
Zfish     1 MHSSTS-----ITSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMEELEKALS 60

  Fly   141 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKEVC 205
            ||||||||||||||||||||||||||||||||||||||||||||||||.|:.|::||.:||||:|
Zfish    61 CPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKALDCCEFPFGSKQKEIC 125

  Fly   206 INPYHYKRVESPVLPPVLVPRHSEFAPGHSML-QFNHVA---EPSMPHNVSYSN-------SGFN 259
            ||||||:|||:||||||||||||||.|.||:| :|.:.:   ||.||.|.::.:       |.|:
Zfish   126 INPYHYRRVETPVLPPVLVPRHSEFNPQHSLLAKFRNASLHNEPLMPQNATFPDSFPAMPCSSFS 190

  Fly   260 SHSLSTSNTS------VGSPSSVNSNPNSPYDSLAGTPPPAY-----SPSEDGNSNNPNDGGQLL 313
            |...|:.|.|      ..||||. :.|.|||...|.||||.|     |||||......::...:|
Zfish   191 SSPSSSLNPSPAAHSFPNSPSSA-TEPGSPYQITAETPPPPYSMMESSPSEDVKPAESSENKLIL 254

  Fly   314 DAQMGDVAQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIVDGFTNPSNNSDRCCLGQLSNVN 378
            .|...|:..|.|.||.:|.|:||||||.||||.||.:..|::|||||:||||.:|.|||.|||||
Zfish   255 TAPQRDLRPVCYEEPEYWCSVAYYELNNRVGETFHASARSILVDGFTDPSNNKNRFCLGLLSNVN 319

  Fly   379 RNSTIENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIF 443
            ||||||:||||||||||||||.|||||||||||:||||||||||.|||||:||||||.|||||||
Zfish   320 RNSTIEHTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYQHGFHPTTVCKIPSGCSLKIF 384

  Fly   444 NNQEFAQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLD 508
            |||.||||||||||:|||.||||||||||||||||||||||||||||||||||||||||||||||
Zfish   385 NNQLFAQLLSQSVNHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLD 449

  Fly   509 KVLTQMGSPHNAISSVS 525
            |||||||||||.|||||
Zfish   450 KVLTQMGSPHNPISSVS 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	109/122 (89%)
Mad	NP_001259992.1	MH2_SMAD_1_5_9	325..525	CDD:199822	171/199 (86%)
smad9	NP_001315428.1	MH1_SMAD_1_5_9	13..136	CDD:199814	109/122 (89%)
smad9	NP_001315428.1	MH2_SMAD_1_5_9	266..466	CDD:199822	171/199 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	325	1.000	Domainoid score	I1166
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	700	1.000	Inparanoid score	I650
OMA	1	1.010	-	-		QHG48637
OrthoDB	1	1.010	-	-		D274383at33208
OrthoFinder	1	1.000	-	-		FOG0000630
OrthoInspector	1	1.000	-	-		otm26196
orthoMCL	1	0.900	-	-		OOG6_103959
Panther	1	1.100	-	-	O	PTHR13703
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2797
SonicParanoid	1	1.000	-	-		X373
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010