Protein Alignment Mad and Med

DIOPT Version :9

• Sequence 1: NP_001259992.1
• Gene: Mad / 33529
• FlyBaseID: FBgn0011648
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_524610.1
• Gene: Med / 43725
• FlyBaseID: FBgn0011655
• Length: 771
• Species: Drosophila melanogaster
• Alignment Length: 722
• Identity: 185/722 - (25%)
• Similarity: 261/722 - (36%)
• Gaps: 312/722 - (43%)

  Fly    98 VKKLLGWKQGDEEEKWAEKAVDSLVKKLKKRKGAIEELERALSCPG-QPSKCVTIPRSLDGRLQV 161
            |..|:..:||.|.|.:|::|::|||||||:::..::.|..|::..| .|||||||.|:|||||||
  Fly    48 VHSLMCHRQGGESEGFAKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQV 112

  Fly   162 SHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYKRVESPVL------- 219
            :.|||.|||||.|:||||||.. :|||.::.|.:.|..|...||:|||||:||.||.:
  Fly   113 AGRKGFPHVIYARIWRWPDLHK-NELKHVKYCAFAFDLKCDSVCVNPYHYERVVSPGIDLSGLSL 176

  Fly   220 ---PPVLV--------------------------------------------------PRHSEFA 231
               |..||                                                  |..:.|.
  Fly   177 QSGPSRLVKDEYSAGPLVGSMDIDGNDIGTIQHHPTQMVGPGGYGYPQGPSEYVGDANPMSAMFP 241

  Fly   232 PGHSMLQFN------------------HVAEP------------SMPHNVSYSNSGFNSHSLSTS 266
            .|.::.:..                  .:.:|            ..|.....:.|...:|||...
  Fly   242 TGRTIPKIEPQDGVAGSRGSWMVPPPPRLGQPPQQQQQQPQQQTPQPTQQQQAQSQAAAHSLPVP 306

  Fly   267 NTSVGSPSSVNSNPNSPYDSLAGTPPPAYSPSEDGN------SNNPND----------------- 308
            :...|.|..:|..|     .:|..|||..:.:..||      :|:|.|
  Fly   307 HGMPGMPGPMNPGP-----VMAPPPPPQQAQNPQGNGVHHTQANSPTDPASALAMQQQQQQQQQQ 366

  Fly   309 ---------------------------GGQLLD------------------------AQMGDVAQ 322
                                       |||...                        .|.|.|:|
  Fly   367 QQQQQQQQQQSGGVPNGSVNAGGGAAAGGQYYGQPPPVSQMQGAGGGGTSVAPSVHAQQNGYVSQ 431

  Fly   323 ----------------------------------------------------------VSYSE-- 327
                                                                      ::|::
  Fly   432 PGSAGSAPVGGGGVFGTAQPTPQQPQQPPTGVQANTGSAGAQAGAGGGAAGTWTGPNTLTYTQSM 496

  Fly   328 ----------------------------------------------PAFWASIAYYELNCRVGEV 346
                                                          |.:|.||||:||:.:|||.
  Fly   497 QPPDPRSLPGGFWNSSLSGDLGSPQQTPPQQQQQQQQPRLLSRQPPPEYWCSIAYFELDTQVGET 561

  Fly   347 FHCNN--NSVIVDGFTNPSNNSDRCCLGQLSNVNRNSTIENTRRHIGKGVHL-YYVTGEVYAECL 408
            |...:  .:||:||:.:|| ..:|.|||.||||:|....|..|.||||||.| ....|:|:..||
  Fly   562 FKVPSAKPNVIIDGYVDPS-GGNRFCLGALSNVHRTEQSERARLHIGKGVQLDLRGEGDVWLRCL 625

  Fly   409 SDSAIFVQSRNCNYHHGFHP-STVCKIPPGCSLKIFNNQEFAQLLSQSVNNGFEA---------- 462
            ||:::||||...:...|..| ..|.||.|...:|:|:.::..|.:.....|...|
  Fly   626 SDNSVFVQSYYLDREAGRTPGDAVHKIYPAACIKVFDLRQCHQQMHSLATNAQAAAAAQAAAVAG 690

  Fly   463 --------------------VYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWL 507
                                |.:|.::|.:|:|||||||.:|.||.:..||||||:|||..||.|
  Fly   691 VANQQMGGGGRSMTAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQLL 755

  Fly   508 DKVLTQM 514
            |:||..|
  Fly   756 DEVLHAM 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	63/118 (53%)
		MH2_SMAD_1_5_9	325..525	CDD:199822	88/272 (32%)
Med	NP_524610.1	MH1_SMAD_4	42..166	CDD:199816	63/118 (53%)
		MH2_SMAD_4	543..760	CDD:199823	85/217 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444265
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13703
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840