Protein Alignment Mad and Dad

DIOPT Version :10

• Sequence 1: NP_001259992.1
• Gene: Mad / 33529
• FlyBaseID: FBgn0011648
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_001369021.1
• Gene: Dad / 42059
• FlyBaseID: FBgn0020493
• Length: 665
• Species: Drosophila melanogaster
• Alignment Length: 575
• Identity: 150/575 - (26%)
• Similarity: 226/575 - (39%)
• Gaps: 165/575 - (28%)

  Fly    28 TISSGSS-NNNNIHHINNNNNHI--------------------CSSGSSNNLNLTTAISGSSNRM 71
            ::|.|.. ||||.|......||:                    |:|...:.|     |.||.  :
  Fly    92 SLSQGQGHNNNNSHPYRRLPNHMDVLPPPPSACDRCCTAPGYSCASSCDDML-----IDGSD--L 149

  Fly    72 DTDD--------------VESNTSSAM----------STLGSLFSF---TSPAVKKLLGWKQGDE 109
            |.|.              :.:.|.:.|          ||.||..:.   ||.|... ....|...
  Fly   150 DQDRSPDQGQVQPVDRRMISATTFTTMFRKCCGGATESTSGSTLTIPVSTSRATAH-PPQTQAQN 213

  Fly   110 EEKWAEKAVDSLVKKLKKRKGAIEELERALSCPGQPSK------------------CVTIPRSLD 156
            .:::.|. .::|:|:| |||...|.|....|....|:|                  |:.||....
  Fly   214 GKRFRED-FEALMKQL-KRKQRNELLLAVKSRLDPPTKTQRDVVEPTTTTAPTYLQCILIPCKTQ 276

  Fly   157 GRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYKRV------E 215
            ...:       |||...|::.|.:|.:..|||.|..|  |.:.....:|.||.|:.|:      |
  Fly   277 TVWE-------PHVTASRLFFWRELWNAKELKRLPTC--PAARDCIYMCCNPLHWFRILHQPETE 332

  Fly   216 SPVLPP-----VLVPRHSEFAPGHSMLQFNHVAEPSMPHNVSYSNSGFNSHSLSTSNTSVGSPSS 275
            ||. ||     :|..:.::|            .|.|.....|.:.|.:::.|.|.||  :..|:.
  Fly   333 SPT-PPYQRSKMLRLKDADF------------EEDSQNDAKSAALSTWSAESTSISN--IYKPAL 382

  Fly   276 VNSNPNSPYDSLAGTPPPAYSPSEDGNSNNPNDGGQLLDAQMGDVAQVSYSEPAFWASIAYYELN 340
                    |:|:          :.||..:|.|             :||       |..|||:|:.
  Fly   383 --------YESV----------TTDGKDHNIN-------------SQV-------WCQIAYWEMA 409

  Fly   341 CRVGEVFHCNNNSVIV--DGFTNPSNNSDRCCLGQLSNVNR--NSTIENTRRHIGKGVHLYYVTG 401
            .||||.||...|:|.:  ||..  ::..|..||..|:....  :|.:...|..:|.||.|....|
  Fly   410 HRVGEFFHAKTNAVNIYTDGIV--ASEVDSMCLRDLTPAGNQIHSVVPKARHTVGLGVTLSLENG 472

  Fly   402 EVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIFNNQEFAQLLSQSVNNGFEAVYEL 466
            :|:.....::.|||.|...:.    :...|||:.||..||.|.... |:|||.. ::|...:..:
  Fly   473 DVWIYNRGNTTIFVDSPTLSE----NLDRVCKVMPGYCLKAFETNR-AELLSMR-DHGHHPMGPV 531

  Fly   467 TKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHL-HGPLQWLDKVLTQMGSPHNA 520
            ... :|::||.||||.:|.|||:...|||:|:|. |...|:|  :|.:...||:|
  Fly   532 DYF-SIKISFGKGWGRDYKRQDIMGCPCWLEVHFSHLRXQYL--MLARSAGPHSA 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	36/149 (24%)
		MH2_SMAD_1_5_9	325..525	CDD:199822	67/201 (33%)
Dad	NP_001369021.1	MH1_SMAD_6_7	197..329	CDD:199813	36/143 (25%)
		MH2_I-SMAD	400..565	CDD:199821	60/173 (35%)