DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mad and SMAD7

DIOPT Version :10

Sequence 1:NP_001259992.1 Gene:Mad / 33529 FlyBaseID:FBgn0011648 Length:525 Species:Drosophila melanogaster
Sequence 2:NP_005895.1 Gene:SMAD7 / 4092 HGNCID:6773 Length:426 Species:Homo sapiens


Alignment Length:403 Identity:112/403 - (27%)
Similarity:172/403 - (42%) Gaps:103/403 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   120 SLVKKLKKRKGAIEELERAL-SCPGQPSKCVTIPRSLDGRL-----------QVSHRKGLPHVIY 172
            |::||||:|:  :|.|.:|: |..|..:.|:.:|..||.||           |......|| ::.
Human    98 SVLKKLKERQ--LELLLQAVESRGGTRTACLLLPGRLDCRLGPGAPAGAQPAQPPSSYSLP-LLL 159

  Fly   173 CRVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYKRVESPVLPPVLVPRHSEFAPGHSML 237
            |:|:|||||:...|:|.|..|:.......:.||.||:|..|:.....||   |.:|.:       
Human   160 CKVFRWPDLRHSSEVKRLCCCESYGKINPELVCCNPHHLSRLCELESPP---PPYSRY------- 214

  Fly   238 QFNHVAEPSMPHNVSYSNSGFNSHSLSTSNTSVGSPSSVNSNPNSPYDSL---AGTPPPAYSPSE 299
                                                         |.|.|   |..|....|.:|
Human   215 ---------------------------------------------PMDFLKPTADCPDAVPSSAE 234

  Fly   300 DGNSNNPNDGGQLLDAQM----GDVAQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIVDGFT 360
            .|.:|....|| |.|:|:    ||        .:.|..:||:|...|||.::.....|  :|.|.
Human   235 TGGTNYLAPGG-LSDSQLLLEPGD--------RSHWCVVAYWEEKTRVGRLYCVQEPS--LDIFY 288

  Fly   361 N-PSNNSDRCCLGQLSNVNRNSTIENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHH 424
            : |..|.  .|||||::.|::..::..|..||.|:.|......|:....|...||::|...:   
Human   289 DLPQGNG--FCLGQLNSDNKSQLVQKVRSKIGCGIQLTREVDGVWVYNRSSYPIFIKSATLD--- 348

  Fly   425 GFHPST----VCKIPPGCSLKIFNNQEFAQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYH 485
              :|.:    |.|:.||.|:|.|   ::.:..|....|..|.:.:.....|:::|||||||..|.
Human   349 --NPDSRTLLVHKVFPGFSIKAF---DYEKAYSLQRPNDHEFMQQPWTGFTVQISFVKGWGQCYT 408

  Fly   486 RQDVTSTPCWIEI 498
            ||.::|.|||:|:
Human   409 RQFISSCPCWLEV 421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MadNP_001259992.1 MH1_SMAD_1_5_9 93..216 CDD:199814 37/107 (35%)
MH2_SMAD_1_5_9 325..525 CDD:199822 55/179 (31%)
SMAD7NP_005895.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 13..55
MH1_SMAD_7 60..205 CDD:199818 37/109 (34%)
Important for interaction with SMURF2 208..217 4/63 (6%)
PY-motif 208..211 2/5 (40%)
MH2_SMAD_7 254..424 CDD:199825 57/188 (30%)
Blue background indicates that the domain is not in the aligned region.

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