DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mad and SMAD6

DIOPT Version :10

Sequence 1:NP_001259992.1 Gene:Mad / 33529 FlyBaseID:FBgn0011648 Length:525 Species:Drosophila melanogaster
Sequence 2:NP_005576.3 Gene:SMAD6 / 4091 HGNCID:6772 Length:496 Species:Homo sapiens


Alignment Length:393 Identity:117/393 - (29%)
Similarity:175/393 - (44%) Gaps:84/393 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   120 SLVKKLKKRKGAIEELERAL-SCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQS 183
            ||:|:||:|  :::.|..|: |..|.|..||.:||:   .|::..:...|.::..|::||||||.
Human   178 SLLKRLKER--SLDTLLEAVESRGGVPGGCVLVPRA---DLRLGGQPAPPQLLLGRLFRWPDLQH 237

  Fly   184 HHELKPLELC-QYPFSAKQKEVCINPYHYKRVESPVLPPVLVPRHSEFAPGHSMLQFNHVAEPSM 247
            ..|||||..| .:..:|....||.||||:.|:..|..||   |.:|..:|               
Human   238 AVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPP---PPYSRLSP--------------- 284

  Fly   248 PHNVSYSNSGFNSHSLSTSNTSVGSPSSVNSNPNSPYDSLAGTPPPAYSPSEDGNSNNPNDGGQL 312
                   ...:....||.|..|.....:.||...:|                          |:.
Human   285 -------RDEYKPLDLSDSTLSYTETEATNSLITAP--------------------------GEF 316

  Fly   313 LDAQMGDVAQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIV-------DGFTNPSNNSDRCC 370
            .||.|...|    ::|:.|.|:||:|...|||.::...:.:|.:       .||          |
Human   317 SDASMSPDA----TKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGF----------C 367

  Fly   371 LGQLSNVNRNSTIENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIP 435
            ||||:...|:.::..||..||.|:.|......|:|....:..|||.|...:...| ....|.|:|
Human   368 LGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGG-RALVVRKVP 431

  Fly   436 PGCSLKIFNNQEFAQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHL 500
            ||.|:|:| :.|.:.|......:..:..|:..   ::|:||.||||..|.||.:||.|||:||.|
Human   432 PGYSIKVF-DFERSGLQHAPEPDAADGPYDPN---SVRISFAKGWGPCYSRQFITSCPCWLEILL 492

  Fly   501 HGP 503
            :.|
Human   493 NNP 495

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MadNP_001259992.1 MH1_SMAD_1_5_9 93..216 CDD:199814 38/97 (39%)
MH2_SMAD_1_5_9 325..525 CDD:199822 61/186 (33%)
SMAD6NP_005576.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..116
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 136..156
MH1_SMAD_6 160..273 CDD:199817 38/99 (38%)
MH2_SMAD_6 322..494 CDD:199824 61/190 (32%)
Blue background indicates that the domain is not in the aligned region.

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