DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mad and SMAD5

DIOPT Version :9

Sequence 1:	NP_001259992.1	Gene:	Mad / 33529	FlyBaseID:	FBgn0011648	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001001419.1	Gene:	SMAD5 / 4090	HGNCID:	6771	Length:	465	Species:	Homo sapiens

Alignment Length:	465	Identity:	342/465 - (73%)
Similarity:	384/465 - (82%)	Gaps:	23/465 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 MSTLGSLFSFTSPAVKKLLGWKQGDEEEKWAEKAVDSLVKKLKKRKGAIEELERALSCPGQPSKC 148
            |:::.|||||||||||:|||||||||||||||||||:|||||||:|||:||||:|||.|||||||
Human     1 MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQPSKC 65

  Fly   149 VTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYKR 213
            ||||||||||||||||||||||||||||||||||||||||||::|::||.:||||||||||||||
Human    66 VTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKR 130

  Fly   214 VESPVLPPVLVPRHSEFAPGHSML-QFNHVA--EPSMPHNVSYSNSGFNSHS----LSTSNTSVG 271
            ||||||||||||||:||.|.||:| ||.:::  ||.||.|.::.:|....::    ||.::....
Human   131 VESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNTPFPLSPNSPYPP 195

  Fly   272 SPSS-------VNSNPNSPYDSLAGTPPPAYSPSED--GNSNN-PNDGGQLLDAQM------GDV 320
            ||:|       .:|.|.||:...|.||||||.|.:|  |..|: |.|....:..|:      .||
Human   196 SPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQPMDTSNNMIPQIMPSISSRDV 260

  Fly   321 AQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIVDGFTNPSNNSDRCCLGQLSNVNRNSTIEN 385
            ..|:|.||..|.||.|||||.||||.||.::.||:|||||:||||..|.|||.||||||||||||
Human   261 QPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSNVNRNSTIEN 325

  Fly   386 TRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIFNNQEFAQ 450
            ||||||||||||||.|||||||||||:|||||||||:||||||:||||||..|||||||||||||
Human   326 TRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQ 390

  Fly   451 LLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMG 515
            ||:||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human   391 LLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMG 455

  Fly   516 SPHNAISSVS 525
            ||.|.|||||
Human   456 SPLNPISSVS 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	110/122 (90%)
Mad	NP_001259992.1	MH2_SMAD_1_5_9	325..525	CDD:199822	172/199 (86%)
SMAD5	NP_001001419.1	MH1_SMAD_1_5_9	10..133	CDD:199814	110/122 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..249		28/85 (33%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	172/199 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	326	1.000	Domainoid score	I1183
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	704	1.000	Inparanoid score	I667
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48637
OrthoDB	1	1.010	-	-		D274383at33208
OrthoFinder	1	1.000	-	-		FOG0000630
OrthoInspector	1	1.000	-	-		otm40519
orthoMCL	1	0.900	-	-		OOG6_103959
Panther	1	1.100	-	-	LDO	PTHR13703
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2797
SonicParanoid	1	1.000	-	-		X373
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910