DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mad and SMAD1

DIOPT Version :9

Sequence 1:NP_001259992.1 Gene:Mad / 33529 FlyBaseID:FBgn0011648 Length:525 Species:Drosophila melanogaster
Sequence 2:NP_001003688.1 Gene:SMAD1 / 4086 HGNCID:6767 Length:465 Species:Homo sapiens


Alignment Length:467 Identity:351/467 - (75%)
Similarity:383/467 - (82%) Gaps:36/467 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 SLFSFTSPAVKKLLGWKQGDEEEKWAEKAVDSLVKKLKKRKGAIEELERALSCPGQPSKCVTIPR 153
            |||||||||||:|||||||||||||||||||:|||||||:|||:||||:|||||||||.||||||
Human     5 SLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQPSNCVTIPR 69

  Fly   154 SLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYKRVESPV 218
            ||||||||||||||||||||||||||||||||||||||.|::||.:|||||||||||||||||||
Human    70 SLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPV 134

  Fly   219 LPPVLVPRHSEFAPGHSML-QFNHVA--EPSMPHNVSYSNSGF---NSHSL-------------S 264
            |||||||||||:.|.||:| ||.::.  ||.||.|.::.:| |   |||..             |
Human   135 LPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDS-FQQPNSHPFPHSPNSSYPNSPGS 198

  Fly   265 TSNTSVGSPSSVNSNPNSPYDSLAGTPPPAYSPSEDGNSNNPNDGGQLLDAQM-----------G 318
            :|:|...||:|  |:|.||:...|.||||||.|.||..:   .||.|.:|..|           |
Human   199 SSSTYPHSPTS--SDPGSPFQMPADTPPPAYLPPEDPMT---QDGSQPMDTNMMAPPLPSEINRG 258

  Fly   319 DVAQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIVDGFTNPSNNSDRCCLGQLSNVNRNSTI 383
            ||..|:|.||..|.||.|||||.||||.||.::.||:|||||:||||.:|.|||.||||||||||
Human   259 DVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTI 323

  Fly   384 ENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIFNNQEF 448
            ||||||||||||||||.|||||||||||:||||||||||||||||:||||||.||||||||||||
Human   324 ENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEF 388

  Fly   449 AQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQ 513
            ||||:||||:|||.|||||||||||||||||||||||||||||||||||||||||||||||||||
Human   389 AQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQ 453

  Fly   514 MGSPHNAISSVS 525
            ||||||.|||||
Human   454 MGSPHNPISSVS 465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MadNP_001259992.1 MH1_SMAD_1_5_9 93..216 CDD:199814 111/122 (91%)
MH2_SMAD_1_5_9 325..525 CDD:199822 174/199 (87%)
SMAD1NP_001003688.1 MH1_SMAD_1_5_9 9..132 CDD:199814 111/122 (91%)
PRK10263 <133..>244 CDD:236669 52/116 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 162..248 35/91 (38%)
MH2_SMAD_1_5_9 265..465 CDD:199822 174/199 (87%)
L3 loop. /evidence=ECO:0000269|PubMed:11779505 418..428 9/9 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 326 1.000 Domainoid score I1183
eggNOG 1 0.900 - - E1_KOG3701
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H21196
Inparanoid 1 1.050 704 1.000 Inparanoid score I667
Isobase 1 0.950 - 0.75 Normalized mean entropy S660
OMA 1 1.010 - - QHG48637
OrthoDB 1 1.010 - - D274383at33208
OrthoFinder 1 1.000 - - FOG0000630
OrthoInspector 1 1.000 - - otm40519
orthoMCL 1 0.900 - - OOG6_103959
Panther 1 1.100 - - O PTHR13703
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2797
SonicParanoid 1 1.000 - - X373
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1514.860

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