Protein Alignment Mad and Smad6

DIOPT Version :10

• Sequence 1: NP_001259992.1
• Gene: Mad / 33529
• FlyBaseID: FBgn0011648
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_001102472.2
• Gene: Smad6 / 367100
• RGDID: 1305069
• Length: 495
• Species: Rattus norvegicus
• Alignment Length: 391
• Identity: 115/391 - (29%)
• Similarity: 177/391 - (45%)
• Gaps: 86/391 - (21%)

  Fly   120 SLVKKLKKRKGAIEELERAL-SCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQS 183
            ||:|:||:|  :::.|..|: |..|.|..||.:||:   .|::..:...|.::..|::||||||.
  Rat   179 SLLKRLKER--SLDTLLEAVESRGGVPGGCVLVPRA---DLRLGGQPAPPQLLLGRLFRWPDLQH 238

  Fly   184 HHELKPLELC-QYPFSAKQKEVCINPYHYKRVESPVLPPVLVPRHSEFAPGHSMLQFNHVAEPSM 247
            ..|||||..| .:..:|....||.||||:.|:..|..||   |.:|..:|            |..
  Rat   239 AVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPP---PPYSRLSP------------PDQ 288

  Fly   248 PHNVSYSNSGFNSHSLSTSNTSVGSPSSVNSNPNSPYDSLAGTPPPAYSPSEDGNSNNPNDGGQL 312
            ...:..|:|..:......:|:.:.:|                                    |:.
  Rat   289 HKPLDLSDSTLSYTETEATNSLITAP------------------------------------GEF 317

  Fly   313 LDAQMGDVAQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIV-------DGFTNPSNNSDRCC 370
            .||.|...|    ::|:.|.|:||:|...|||.::...:.:|.:       .||          |
  Rat   318 SDASMSPDA----TKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGF----------C 368

  Fly   371 LGQLSNVNRNSTIENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIP 435
            ||||:...|:.::..||..||.|:.|......|:|....:..|||.|...:...| ....|.|:|
  Rat   369 LGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGG-RALVVRKVP 432

  Fly   436 PGCSLKIFNNQEFAQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHL 500
            ||.|:|:| :.|.:.||..:     :|.:......::|:||.||||..|.||.:||.|||:||.|
  Rat   433 PGYSIKVF-DFERSGLLQHA-----DAAHGPYDPHSVRISFAKGWGPCYSRQFITSCPCWLEILL 491

  Fly   501 H 501
            :
  Rat   492 N 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	38/97 (39%)
		MH2_SMAD_1_5_9	325..525	CDD:199822	61/184 (33%)
Smad6	NP_001102472.2	MH1_SMAD_6	161..274	CDD:199817	38/99 (38%)
		MH2_SMAD_6	323..493	CDD:199824	62/191 (32%)