Protein Alignment Mad and smad7

DIOPT Version :9

• Sequence 1: NP_001259992.1
• Gene: Mad / 33529
• FlyBaseID: FBgn0011648
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_778257.2
• Gene: smad7 / 326282
• ZFINID: ZDB-GENE-030128-3
• Length: 372
• Species: Danio rerio
• Alignment Length: 450
• Identity: 121/450 - (26%)
• Similarity: 183/450 - (40%)
• Gaps: 135/450 - (30%)

  Fly    77 ESNTSSAMSTLG-SLFSFTSPAVKKLLGWKQGDEEEKWAEKAVD-SLVKKLKKRKGAIEELERAL 139
            :::|.:...|.| .|.|..:|          |.|.|.   ||:. |::||:|:::  :|.|.:|:
Zfish    25 DADTGTRGGTAGCCLASKPNP----------GTEAEL---KALTYSILKKIKEKQ--LEVLLQAV 74

  Fly   140 -SCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKE 203
             |..|..|.|:.:|...|.||. .|...||.::| :|:|||||:...|||.|..|:.......:.
Zfish    75 ESRGGARSPCLLLPGKADARLG-QHSYPLPLLLY-KVFRWPDLRHSSELKRLSCCESYGKINPEL 137

  Fly   204 VCINPYHYKRVESPVLPPVLVPRHSEFAPGHSMLQFNHVAEPSMPHNVSYSNSGFNSHSLSTSNT 268
            ||.||:|..|:.....||   |.:|.:
Zfish   138 VCCNPHHMSRLCELESPP---PPYSRY-------------------------------------- 161

  Fly   269 SVGSPSSVNSNPNSPYDSLAGTPPPAYSPSEDGNSNNPNDGGQLLDAQMG---DVAQVSYSEPAF 330
                |:.....|:||     |:.|.           :...||....|.||   .:|.....|...
Zfish   162 ----PTDFLKPPDSP-----GSVPA-----------STETGGTAYSAPMGFSDSLALQERGEQPH 206

  Fly   331 WASIAYYELNCRVGEVFHCNNNSVIV-------DGFTNPSNNSDRCCLGQLSNVNRNSTIENTRR 388
            |..:||:|...|||.::.....|:.:       .||          |||||::.|::..::..|.
Zfish   207 WCVVAYWEEKTRVGRLYSVQEPSLDIFYDLPQGTGF----------CLGQLASENKSQLVQMVRA 261

  Fly   389 HIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPST----VCKIPPGCSLKIF------ 443
            .||.|:.|......|:....|...||::|...:     :|.:    |.|:.||.|:|.|
Zfish   262 KIGYGIQLSREADGVWVYNRSCYPIFIKSATLD-----NPDSRTLLVHKVFPGFSIKAFDFEKAG 321

  Fly   444 -----NNQEFAQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEI 498
                 |:.||    ||....||          |:::|||||||..|.||.::|.|||:|:
Zfish   322 SLQRPNDHEF----SQQPRTGF----------TVQISFVKGWGQCYTRQFISSCPCWLEV 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	42/124 (34%)
		MH2_SMAD_1_5_9	325..525	CDD:199822	58/195 (30%)
smad7	NP_778257.2	MH1_SMAD_7	36..152	CDD:199818	45/132 (34%)
		MH2_SMAD_7	200..370	CDD:199825	58/196 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810