DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mad and smad5

DIOPT Version :9

Sequence 1:	NP_001259992.1	Gene:	Mad / 33529	FlyBaseID:	FBgn0011648	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001333238.1	Gene:	smad5 / 30641	ZFINID:	ZDB-GENE-990603-9	Length:	464	Species:	Danio rerio

Alignment Length:	468	Identity:	347/468 - (74%)
Similarity:	385/468 - (82%)	Gaps:	30/468 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 MSTLGSLFSFTSPAVKKLLGWKQGDEEEKWAEKAVDSLVKKLKKRKGAIEELERALSCPGQPSKC 148
            |:::.|||||||||||:|||||||||||||||||||:|||||||:|||:|:||:|||.|||||||
Zfish     1 MTSMSSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEDLEKALSSPGQPSKC 65

  Fly   149 VTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYKR 213
            |||||||||||||||||||||||||||||||||||||||||||:|:|||.:||||||||||||||
Zfish    66 VTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLEVCEYPFGSKQKEVCINPYHYKR 130

  Fly   214 VESPVLPPVLVPRHSEFAPGHSML-QFNHVA--EPSMPHNVSYSNSGFNSH-------------- 261
            |||||||||||||||||.|.||:| ||.:::  ||.||.|.::..| |..|
Zfish   131 VESPVLPPVLVPRHSEFNPQHSLLVQFRNLSHNEPHMPLNATFPES-FQQHSGGSSFPISPNSPY 194

  Fly   262 --SLSTSNTSVGSPSSVNSNPNSPYDSLAGTPPPAYSP-----SEDGNSNNPNDGGQLLDAQM-- 317
              |.::|.|...||:|  |.|:||:...|.||||||.|     .:|| |.:...|..|....|
Zfish   195 PPSPASSGTYPNSPAS--SGPSSPFQLPADTPPPAYMPPDEQMGQDG-SQSMETGSSLAPQNMPR 256

  Fly   318 GDVAQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIVDGFTNPSNNSDRCCLGQLSNVNRNST 382
            |||..|.|.||:.|.||.|||||.||||.:|.::.||:|||||:||||.:|.|||.|||||||||
Zfish   257 GDVQPVEYQEPSHWCSIVYYELNNRVGEAYHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNST 321

  Fly   383 IENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIFNNQE 447
            |||||||||||||||||.||||||||||::||||||||||||||||:||||||.|||||||||||
Zfish   322 IENTRRHIGKGVHLYYVGGEVYAECLSDTSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQE 386

  Fly   448 FAQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLT 512
            |||||:||||:|||||||||||||||||||||||||||||||||||||||:||||||||||||||
Zfish   387 FAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEVHLHGPLQWLDKVLT 451

  Fly   513 QMGSPHNAISSVS 525
            |||||.|.|||||
Zfish   452 QMGSPLNPISSVS 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	111/122 (91%)
Mad	NP_001259992.1	MH2_SMAD_1_5_9	325..525	CDD:199822	171/199 (86%)
smad5	NP_001333238.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..258		30/95 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	325	1.000	Domainoid score	I1166
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	700	1.000	Inparanoid score	I650
OMA	1	1.010	-	-		QHG48637
OrthoDB	1	1.010	-	-		D274383at33208
OrthoFinder	1	1.000	-	-		FOG0000630
OrthoInspector	1	1.000	-	-		otm26196
orthoMCL	1	0.900	-	-		OOG6_103959
Panther	1	1.100	-	-	LDO	PTHR13703
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2797
SonicParanoid	1	1.000	-	-		X373
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910