Protein Alignment Mad and daf-3

DIOPT Version :9

• Sequence 1: NP_001259992.1
• Gene: Mad / 33529
• FlyBaseID: FBgn0011648
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_001300341.1
• Gene: daf-3 / 180431
• WormBaseID: WBGene00000899
• Length: 895
• Species: Caenorhabditis elegans
• Alignment Length: 720
• Identity: 151/720 - (20%)
• Similarity: 243/720 - (33%)
• Gaps: 274/720 - (38%)

  Fly    55 SNNLNLT-----------TAISGSSNRMDTDDVESNTSSAM-----------STLGSLFSFTSPA 97
            :.|.|:|           .|:..:..:::..|..:..:..:           |.|..|.::.:..
 Worm   160 TKNTNMTEYDLDVLKLGKPAVDEARKKIEVPDASAPPNKIVEYLMYYRTLKESELIQLNAYRTKR 224

  Fly    98 VKKLLGWKQGDEEEKWAEKAVDSLVKKLKKRKGAIEEL-ERALSCPGQPSKCVTIPRSLDGRLQV 161
            .:..|...:.:.:.::.:||.:|||||||.:|..::.| :..||...:.:.|:||||:|||||||
 Worm   225 NRLSLNLVKNNIDREFDQKACESLVKKLKDKKNDLQNLIDVVLSKGTKYTGCITIPRTLDGRLQV 289

  Fly   162 SHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQK---EVCINPYHYKRV--------- 214
            ..|||.|||:|.::||:.:: :.:|.:.::.|::.|..|..   |||:|||||:.|
 Worm   290 HGRKGFPHVVYGKLWRFNEM-TKNETRHVDHCKHAFEMKSDMVGEVCVNPYHYEIVIGTMIVGQR 353

  Fly   215 -------------------ESPV------LPPVLV-----------------------------P 225
                               :.||      :||..:                             |
 Worm   354 DHDNRDMPPPHQRYHTPGRQDPVDDMSRFIPPASIRPPPMNMHTRPQPMPQQLPSVGATFAHPLP 418

  Fly   226 RHSEFAPG-----------HSMLQFNHVAE----PSMPHNVSYSNSGFNSHSLSTSNTSVGSPSS 275
            ..:...||           |..|..|.:.:    |.||..: :...|.|..|.|:.|   .:|..
 Worm   419 HQAPHNPGVSHPYSIAPQTHYPLNMNPIPQMPQMPQMPPPL-HQGYGMNGPSCSSEN---NNPFH 479

  Fly   276 VN------SNPNS-PYD---SLAGTPPP---------------------------AYSPSEDGNS 303
            .|      |:||. .||   :|.|.|.|                           ::.|...|..
 Worm   480 QNHHYNDISHPNHYSYDCGPNLYGFPTPYPDFHHPFNQQPHQPPQLSQNHTSQQGSHQPGHQGQV 544

  Fly   304 NNPND------------------------------------------------------------ 308
              |||
 Worm   545 --PNDPPISRPVLQPSTVTLDVFRRYCRQTFGNRFFEGESEQSGAIIRSSNKFIEEFDSPICGVT 607

  Fly   309 -------GGQLL------DAQMGDVAQ---------VSYSEPA--------FWASIAYYELNCRV 343
                   .|::|      ||...|:.:         |::|...        .|.:|.|||.|.::
 Worm   608 VVRPRMTDGEVLENIMPEDAPYHDICKFILRLTSESVTFSGEGPEVSDLNEKWGTIVYYEKNLQI 672

  Fly   344 GEVFHCNNNSVIVDGFTNPSNNSDRCCLGQLSNVNRNSTIENTRRHIGKGVHL-YYVTGEVYAEC 407
            ||. .|:..:..|||....|.|  |..||...|..|.......|:.|..|:.. |...|.|:.:.
 Worm   673 GEK-KCSRGNFHVDGGFICSEN--RYSLGLEPNPIREPVAFKVRKAIVDGIRFSYKKDGSVWLQN 734

  Fly   408 LSDSAIFVQSRNCNYHH-GFHPSTVCKIPPGCSLKIFN-------------NQEFAQLLSQSVNN 458
            .....:||.|...:... |.....|.|:....|:|.|.             :::.|.:..|....
 Worm   735 RMKYPVFVTSGYLDEQSGGLKKDKVHKVYGCASIKTFGFNVSKQIIRDALLSKQMATMYLQGKLT 799

  Fly   459 GFEAVYE-----------------LTKMCTIRMSFVKGWGAEY-HRQDVTSTPCWIEIHLHGPLQ 505
            ....:||                 |.|.|.:|:||.||:|..| .|..:...|.|||:.::....
 Worm   800 PMNYIYEKKTQEELRREATRTTDSLAKYCCVRVSFCKGFGEAYPERPSIHDCPVWIELKINIAYD 864

  Fly   506 WLDKV 510
            ::|.:
 Worm   865 FMDSI 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	48/154 (31%)
		MH2_SMAD_1_5_9	325..525	CDD:199822	55/227 (24%)
daf-3	NP_001300341.1	MH1_SMAD_4	218..346	CDD:199816	48/128 (38%)
		DWB	659..860	CDD:197770	53/203 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910