Protein Alignment Mad and sma-2

DIOPT Version :10

• Sequence 1: NP_001259992.1
• Gene: Mad / 33529
• FlyBaseID: FBgn0011648
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_001370321.1
• Gene: sma-2 / 176229
• WormBaseID: WBGene00004856
• Length: 418
• Species: Caenorhabditis elegans
• Alignment Length: 445
• Identity: 230/445 - (51%)
• Similarity: 288/445 - (64%)
• Gaps: 50/445 - (11%)

  Fly    98 VKKL---LGWKQGDEEEKWAEKAVDSLVKKL-KKRKGAIEELERALSCPG-QPSKCVTIPRSLDG 157
            :||:   |.||||||:|.||:||:|:|:||| |..|.|:|.||.||.|.| |.::||||||||||
 Worm     7 IKKITERLKWKQGDEDENWAKKAIDNLMKKLIKHNKQALENLEFALRCQGQQKTECVTIPRSLDG 71

  Fly   158 RLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYKRVESP-VLPP 221
            |||:||||.|||||||||:||||||||||||.:|.|::.:.:.||::||||||||||.:. ||||
 Worm    72 RLQISHRKALPHVIYCRVYRWPDLQSHHELKAIEDCRFCYESGQKDICINPYHYKRVHATGVLPP 136

  Fly   222 VLVPRHSEFAPGH-----SMLQFNHVAEPSMPHNVSYSNSGFNSHSLSTSNTSVGSPSSVNS-NP 280
            |||||:||..|..     :..|...::...||.||:.:|..|.::.....|     |:.:.. :.
 Worm   137 VLVPRYSEKPPQEVPPTLAKFQLMEMSGSRMPQNVNMANVNFTANQFHQYN-----PNGIEEMDT 196

  Fly   281 NSPYDSLAGTPPPAYSPSEDGNSNNPNDGGQLLDAQMGDVAQVSYS---EPAFWASIAYYELNCR 342
            :..:|...|.|                            ...|.:.   |..|||:::|||||.|
 Worm   197 SQKFDIPPGVP----------------------------TCLVPFDKVWEEQFWATVSYYELNTR 233

  Fly   343 VGEVFHCNNNSVIVDGFTNPSNNSDRCCLGQLSNVNRNSTIENTRRHIGKGVHLYYV--TGEVYA 405
            |||....::.::.:||||:|..|..:..||..||||||:||||||||||.||.|.||  .|.::|
 Worm   234 VGEQVKVSSTTITIDGFTDPCINGSKISLGLFSNVNRNATIENTRRHIGNGVKLTYVRSNGSLFA 298

  Fly   406 ECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIFNNQEFAQLLSQSVNNGFEAVYELTKMC 470
            :|.|||||||||.||||.:|||.:||.||...||||||:.:.|.|||......||:|.::|.||.
 Worm   299 QCESDSAIFVQSSNCNYINGFHSTTVVKIANKCSLKIFDMEIFRQLLEDCSRRGFDASFDLQKMT 363

  Fly   471 TIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNAISSVS 525
            .|||||||||||||.||||||||||||||||.||.|||:||:.||.....|||:|
 Worm   364 FIRMSFVKGWGAEYQRQDVTSTPCWIEIHLHAPLAWLDRVLSTMGPTPRPISSIS 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	82/122 (67%)
		MH2_SMAD_1_5_9	325..525	CDD:199822	122/204 (60%)
sma-2	NP_001370321.1	MH1	5..130	CDD:469592	82/122 (67%)
		MH2_R-SMAD	222..405	CDD:199820	114/182 (63%)