Protein Alignment Mad and sma-3

DIOPT Version :10

• Sequence 1: NP_001259992.1
• Gene: Mad / 33529
• FlyBaseID: FBgn0011648
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_498493.1
• Gene: sma-3 / 175955
• WormBaseID: WBGene00004857
• Length: 393
• Species: Caenorhabditis elegans
• Alignment Length: 439
• Identity: 199/439 - (45%)
• Similarity: 257/439 - (58%)
• Gaps: 71/439 - (16%)

  Fly    87 LGSLFSFTSPAVKKLLGWKQGDEEEKWAEKAVDSLVKKLKKRK---GAIEELERALSCPGQPSKC 148
            :..|.....||||||||||.|::||||.||||::|||||||:.   |.:|:||..|:.|...|:|
 Worm     1 MNGLLHMHGPAVKKLLGWKIGEDEEKWCEKAVEALVKKLKKKNNGCGTLEDLECVLANPCTNSRC 65

  Fly   149 VTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPF--SAKQKEVCINPYHY 211
            :||.:||||||||||:||||||||||||||||:.|.|||:.::.|.||:  |:|...:|||||||
 Worm    66 ITIAKSLDGRLQVSHKKGLPHVIYCRVWRWPDISSPHELRSIDTCSYPYESSSKTMYICINPYHY 130

  Fly   212 KRVESPVLPPVLVPRHSEFAPGHSMLQFNHVAEPSMPHNVSYSNSGFNSHSLSTSNTSVGSPSSV 276
            :|:..|                                      .|.||.  ..|...:.||:::
 Worm   131 QRLSRP--------------------------------------QGLNSS--MPSPQPISSPNTI 155

  Fly   277 NSNPNSPYDSLAGTPPPAYSPSEDGNSNNPNDGGQLLDAQMGDVAQVSYSEPAF-----WASIAY 336
            ..:..|...|.|.:|.|:.. ||||                |:| ||....|.|     ||.|.|
 Worm   156 WQSSGSSTASCASSPSPSVF-SEDG----------------GEV-QVHQRPPPFRHPKSWAQITY 202

  Fly   337 YELNCRVGEVFHCNNNSVIVDGFTNPSNNSDRCCLGQLSNVNRNSTIENTRRHIGKGVHLYYVTG 401
            :|||.||||||...|.|:.|||:|||||::.|.|||||:|||||.||||||.|||||:.|.....
 Worm   203 FELNSRVGEVFKLVNLSITVDGYTNPSNSNTRICLGQLTNVNRNGTIENTRMHIGKGIQLDNKED 267

  Fly   402 EVYAECL--SDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIFNNQEFAQLLSQSVNNGFEAVY 464
            :::....  ||..:||||:|.|.........||:|||...|.:|....|.|:|.||.|:. :.:.
 Worm   268 QMHIMITNNSDMPVFVQSKNTNLMMNMPLVKVCRIPPHSQLCVFEFNLFFQMLEQSCNDS-DGLN 331

  Fly   465 ELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQ 513
            ||:|.|.||:|||||||.:|.||||||||||:|:.|:.||.::|:.:.|
 Worm   332 ELSKHCFIRISFVKGWGEDYPRQDVTSTPCWLELRLNVPLAYIDQKMKQ 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	79/127 (62%)
		MH2_SMAD_1_5_9	325..525	CDD:199822	99/196 (51%)
sma-3	NP_498493.1	MH1	10..133	CDD:469592	78/122 (64%)
		MH2_R-SMAD	197..379	CDD:199820	96/182 (53%)