Protein Alignment Mad and tag-68

DIOPT Version :10

• Sequence 1: NP_001259992.1
• Gene: Mad / 33529
• FlyBaseID: FBgn0011648
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_492746.2
• Gene: tag-68 / 172930
• WormBaseID: WBGene00006445
• Length: 415
• Species: Caenorhabditis elegans
• Alignment Length: 443
• Identity: 91/443 - (20%)
• Similarity: 143/443 - (32%)
• Gaps: 155/443 - (34%)

  Fly   132 IEELERALSCPGQPSKCVTIPRSLDGRL-------------QVSHRKGLPHVIYCRVWRWPDLQ- 182
            :|.:.:|:...|..||.......:|.|:             |:.....:|: :.|::|||.|||
 Worm    49 VEVIRKAVESDGVDSKACAPGPPMDERVEEDPPDEDSGLIPQIDRPMSMPY-LCCKLWRWKDLQV 112

  Fly   183 --SHHELKPLELCQY-PFSAKQKEV-CINPYHYKRVESPVLPPVLVPRHSEFAPG---------H 234
              :.|.|:.|..|:: ..:.....| |.|||||.....|           |...|         .
 Worm   113 DAALHRLEALPWCRFGRVTINNATVSCCNPYHYALWIRP-----------ETNGGDDDGSEDKNS 166

  Fly   235 SMLQFNHVAEPSMPHNVSYSNSGFNSHSLSTSNTS---VGS------PSSVNSNPNSPYDSLAGT 290
            |:.|.||.:......:::|.:.. ::|....|...   .|.      ||..|:.|..|.||
 Worm   167 SVPQNNHRSSLIGNGHITYRHRD-HTHDAEMSKLPKILAGELPDRPPPSVPNATPPLPDDS---- 226

  Fly   291 PPPAYSPSEDGNSNNPNDGGQLLDAQMGDVAQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVI 355
             ||..|.|    |.:|:|   |:...       .:.....||.:..||...::|:....:.....
 Worm   227 -PPCTSRS----SQDPDD---LIHYH-------HHESNRSWAKMTRYERKEQIGDTVWLHGPFAA 276

  Fly   356 VDGFTNPSNNSDRCCLGQLSNVNRNSTIENTRRHIGKGVHLYYVTGEVYAEC----LSDSAIFVQ 416
            |               |.||                |.||      :...||    |.:...|..
 Worm   277 V---------------GVLS----------------KSVH------DAQLECSPWDLKNEVSFAL 304

  Fly   417 SRNCN------------YHHGFHP-------------STVCKIPPGCSLKIFNNQEFAQLLSQSV 456
            .|..:            |:.|..|             .|:.::.||..:::...:..|...:.
 Worm   305 IRQADPIGSTNPEDVWLYNSGTRPLFLSMTPNVSSTKDTLRRLSPGYCIRVHRGEVSASAPAS-- 367

  Fly   457 NNGFEAVYELTKM-----------CTIRMSFVKGWGAEYHRQDVTSTPCWIEI 498
                    |.||:           ..:.:|..||||..|.|..:|..||..|:
 Worm   368 --------ERTKVRRPSKDPALAQQNLVISVGKGWGPNYSRLYLTDIPCRYEV 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	27/101 (27%)
		MH2_SMAD_1_5_9	325..525	CDD:199822	38/214 (18%)
tag-68	NP_492746.2	MH1_SMAD_6_7	14..152	CDD:199813	28/114 (25%)
		MH2	251..415	CDD:469593	38/209 (18%)