Protein Alignment Mad and Smad6

DIOPT Version :9

• Sequence 1: NP_001259992.1
• Gene: Mad / 33529
• FlyBaseID: FBgn0011648
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_032568.3
• Gene: Smad6 / 17130
• MGIID: 1336883
• Length: 495
• Species: Mus musculus
• Alignment Length: 391
• Identity: 118/391 - (30%)
• Similarity: 176/391 - (45%)
• Gaps: 86/391 - (21%)

  Fly   120 SLVKKLKKRKGAIEELERAL-SCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQS 183
            ||:|:||:|  :::.|..|: |..|.|..||.:||:   .|::..:...|.::..|::||||||.
Mouse   179 SLLKRLKER--SLDTLLEAVESRGGVPGGCVLVPRA---DLRLGGQPAPPQLLLGRLFRWPDLQH 238

  Fly   184 HHELKPLELC-QYPFSAKQKEVCINPYHYKRVESPVLPPVLVPRHSEFAPGHSMLQFNHVAEPSM 247
            ..|||||..| .:..:|....||.||||:.|:..|..||   |.:|..:|            |..
Mouse   239 AVELKPLCGCHSFTAAADGPTVCCNPYHFSRLCGPESPP---PPYSRLSP------------PDQ 288

  Fly   248 PHNVSYSNSGFNSHSLSTSNTSVGSPSSVNSNPNSPYDSLAGTPPPAYSPSEDGNSNNPNDGGQL 312
                      :....||.|..|.....:.||...:|                          |:.
Mouse   289 ----------YKPLDLSDSTLSYTETEATNSLITAP--------------------------GEF 317

  Fly   313 LDAQMGDVAQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIV-------DGFTNPSNNSDRCC 370
            .||.|...|    ::|:.|.|:||:|...|||.::...:.:|.:       .||          |
Mouse   318 SDASMSPDA----TKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGF----------C 368

  Fly   371 LGQLSNVNRNSTIENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIP 435
            ||||:...|:.::..||..||.|:.|......|:|....:..|||.|...:...| ....|.|:|
Mouse   369 LGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGG-RALVVRKVP 432

  Fly   436 PGCSLKIFNNQEFAQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHL 500
            ||.|:|:| :.|.:.||..:     :|.:......::|:||.||||..|.||.:||.|||:||.|
Mouse   433 PGYSIKVF-DFERSGLLQHA-----DAAHGPYDPHSVRISFAKGWGPCYSRQFITSCPCWLEILL 491

  Fly   501 H 501
            :
Mouse   492 N 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	38/97 (39%)
		MH2_SMAD_1_5_9	325..525	CDD:199822	61/184 (33%)
Smad6	NP_032568.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..115
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	133..161
		MH1_SMAD_6	161..274	CDD:199817	38/99 (38%)
		MH2_SMAD_6	323..493	CDD:199824	62/191 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810