DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mad and Smad5

DIOPT Version :9

Sequence 1:	NP_001259992.1	Gene:	Mad / 33529	FlyBaseID:	FBgn0011648	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001157513.1	Gene:	Smad5 / 17129	MGIID:	1328787	Length:	465	Species:	Mus musculus

Alignment Length:	465	Identity:	340/465 - (73%)
Similarity:	382/465 - (82%)	Gaps:	23/465 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 MSTLGSLFSFTSPAVKKLLGWKQGDEEEKWAEKAVDSLVKKLKKRKGAIEELERALSCPGQPSKC 148
            |:::.|||||||||||:|||||||||||||||||||:|||||||:|||:||||:|||.|||||||
Mouse     1 MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQPSKC 65

  Fly   149 VTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYKR 213
            ||||||||||||||||||||||||||||||||||||||||||::|::||.:||||||||||||||
Mouse    66 VTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKR 130

  Fly   214 VESPVLPPVLVPRHSEFAPGHSML-QFNHVA--EPSMPHNVSYSNSGFNSHS----LSTSNTSVG 271
            ||||||||||||||:||.|.||:| ||.:::  ||.||.|.::.:|....::    ||.::....
Mouse   131 VESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNAPFPLSPNSPYPP 195

  Fly   272 SPSS-------VNSNPNSPYDSLAGTPPPAYSPSED----GNSNNPNDGGQLLDAQM-----GDV 320
            ||:|       .:|.|.||:...|.||||||.|.:|    .||...:....::...|     .||
Mouse   196 SPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMAPDNSQPMDTSSNMIPQTMPSISSRDV 260

  Fly   321 AQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIVDGFTNPSNNSDRCCLGQLSNVNRNSTIEN 385
            ..|:|.||..|.||.|||||.||||.||.::.||:|||||:||||..|.|||.||||||||||||
Mouse   261 QPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSNVNRNSTIEN 325

  Fly   386 TRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIFNNQEFAQ 450
            ||||||||||||||.|||||||||||:|||||||||:||||||:||||||..|||||||||||||
Mouse   326 TRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQ 390

  Fly   451 LLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMG 515
            ||:||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 LLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMG 455

  Fly   516 SPHNAISSVS 525
            ||.|.|||||
Mouse   456 SPLNPISSVS 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	110/122 (90%)
Mad	NP_001259992.1	MH2_SMAD_1_5_9	325..525	CDD:199822	172/199 (86%)
Smad5	NP_001157513.1	MH1_SMAD_1_5_9	10..133	CDD:199814	110/122 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..251		26/87 (30%)
		MH2_SMAD_1_5_9	265..465	CDD:199822	172/199 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	326	1.000	Domainoid score	I1183
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	703	1.000	Inparanoid score	I659
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48637
OrthoDB	1	1.010	-	-		D274383at33208
OrthoFinder	1	1.000	-	-		FOG0000630
OrthoInspector	1	1.000	-	-		otm42592
orthoMCL	1	0.900	-	-		OOG6_103959
Panther	1	1.100	-	-	LDO	PTHR13703
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2797
SonicParanoid	1	1.000	-	-		X373
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910