DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mad and Smad2

DIOPT Version :9

Sequence 1:NP_001259992.1 Gene:Mad / 33529 FlyBaseID:FBgn0011648 Length:525 Species:Drosophila melanogaster
Sequence 2:NP_001239410.1 Gene:Smad2 / 17126 MGIID:108051 Length:467 Species:Mus musculus


Alignment Length:499 Identity:283/499 - (56%)
Similarity:333/499 - (66%) Gaps:92/499 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 LGSLFSFTSPAVKKLLGWK-------------QGDEEEKWAEKAVDSLVKKLKKRKGAIEELERA 138
            :.|:..||.|.||:|||||             |..:||||.||||.|||||||| .|.::|||:|
Mouse     1 MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKK-TGRLDELEKA 64

  Fly   139 LSCPGQPSKCVTIP------------------------------RSLDGRLQVSHRKGLPHVIYC 173
            ::.....:||||||                              |||||||||||||||||||||
Mouse    65 ITTQNCNTKCVTIPSTCSEIWGLSTANTVDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYC 129

  Fly   174 RVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYKRVESPVLPPVLVPRHSEFAPGHSML- 237
            |:||||||.||||||.:|.|:|.|:.|:.|||:|||||:|||:|||||||||||:|.......| 
Mouse   130 RLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLD 194

  Fly   238 QFNHVAEPSMPHNVSYSNSGFNSHSLSTSNTSVGSPSSVNSNPNSPYDSLAGTPPPAYSPSEDGN 302
            .:.|    |:|.|.::                   |:.:  .|.|.|  :..||||.|. ||||.
Mouse   195 DYTH----SIPENTNF-------------------PAGI--EPQSNY--IPETPPPGYI-SEDGE 231

  Fly   303 S-----NNPNDGGQLLDAQMG-----------DVAQVSYSEPAFWASIAYYELNCRVGEVFHCNN 351
            :     |...|.|.  .|::.           |:..|:|||||||.||||||||.||||.||.:.
Mouse   232 TSDQQLNQSMDTGS--PAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQ 294

  Fly   352 NSVIVDGFTNPSNNSDRCCLGQLSNVNRNSTIENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQ 416
            .|:.|||||:|| ||:|.|||.|||||||:|:|.||||||:||.|||:.|||:||||||||||||
Mouse   295 PSLTVDGFTDPS-NSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQ 358

  Fly   417 SRNCNYHHGFHPSTVCKIPPGCSLKIFNNQEFAQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWG 481
            |.|||..:|:||:|||||||||:||||||||||.||:||||.||||||:||:|||||||||||||
Mouse   359 SPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWG 423

  Fly   482 AEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNAISSVS 525
            |||.||.|||||||||:||:||||||||||||||||....||:|
Mouse   424 AEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS 467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MadNP_001259992.1 MH1_SMAD_1_5_9 93..216 CDD:199814 87/165 (53%)
MH2_SMAD_1_5_9 325..525 CDD:199822 157/199 (79%)
Smad2NP_001239410.1 MH1_SMAD_2_3 8..172 CDD:199815 86/164 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 207..251 17/50 (34%)
PY-motif. /evidence=ECO:0000250 221..225 3/3 (100%)
MH2_SMAD_2_3 266..456 CDD:199826 151/190 (79%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3701
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D274383at33208
OrthoFinder 1 1.000 - - FOG0000630
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X373
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.820

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