Protein Alignment Mad and Smox

DIOPT Version :10

• Sequence 1: NP_001259992.1
• Gene: Mad / 33529
• FlyBaseID: FBgn0011648
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: XP_318870.3
• Gene: Smox / 1279189
• VectorBaseID: AGAMI1_006596
• Length: 506
• Species: Anopheles gambiae
• Alignment Length: 525
• Identity: 259/525 - (49%)
• Similarity: 317/525 - (60%)
• Gaps: 108/525 - (20%)

  Fly    90 LFSFTSPAVKKLLGWKQ----GDEEEKWAEKAVDSLVKKLKKRKGAIEELERALSCPGQPSKCVT 150
            :..||.|.||:||||::    ...|.||.||.:.||.||:|| ..|:|||||||:.....:||:.
Mosquito     1 MLPFTPPIVKRLLGWRKVSPDDSAEGKWGEKVIKSLAKKMKK-SSALEELERALTAQSSHTKCIP 64

  Fly   151 IPR--SLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKEVCINPYHYKR 213
            |.|  |..|...|:.:|||||||.||:||||||.||.|||||::|:|.:..|:.|||||||||.|
Mosquito    65 ISRNASAIGENGVALKKGLPHVICCRLWRWPDLNSHTELKPLDVCEYAYHLKKDEVCINPYHYAR 129

  Fly   214 VESPVLPPVLVPRHSEFAPGHSMLQFNHVAEPS-----------MPHNVSYSNSGFNS------- 260
            .||          ||:    ||..|.:...:.|           :|.|:| ::.|.||
Mosquito   130 NES----------HSQ----HSQQQQSPQQQQSSQQLQQPLTILVPKNLS-NSQGENSVTYTLDD 179

  Fly   261 -----------HSLSTSNTSVGSPSSVNS--------NPNSPYDSL------------------- 287
                       ::|:.:..:...||.|.|        .||..:..|
Mosquito   180 LSNTVPVNTQYNALNDNYVTSPQPSQVTSRQLQQQQLQPNQLHQQLQQQQQQQQLSSPCYMEATL 244

  Fly   288 -----------------------AGTPPPAYSPSEDGN----SNNPNDGGQLLDAQMGDVAQVSY 325
                                   ..||||.|. ||||:    ::|..|..::..::| |...|.|
Mosquito   245 GQQIPTNTTIMDSVSVGVPNIPNTETPPPGYM-SEDGDPLDQNDNMTDLSRMSPSEM-DTQPVMY 307

  Fly   326 SEPAFWASIAYYELNCRVGEVFHCNNNSVIVDGFTNPSNNSDRCCLGQLSNVNRNSTIENTRRHI 390
            .||.||.||:|||||.||||.||.:..|:.|||||:|| ||:|.|||.|||||||..:|.|||||
Mosquito   308 HEPTFWCSISYYELNLRVGETFHASQPSITVDGFTDPS-NSERFCLGLLSNVNRNEVVEQTRRHI 371

  Fly   391 GKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYHHGFHPSTVCKIPPGCSLKIFNNQEFAQLLSQS 455
            ||||.|||:.|||:|||||||:|||||.|||..:|:||:|||||||||:||||||||||.|||||
Mosquito   372 GKGVRLYYIGGEVFAECLSDSSIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFATLLSQS 436

  Fly   456 VNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNA 520
            |:.||||||:||:||||||||||||||||.||.|||||||||:||:|||||||:||||||||...
Mosquito   437 VSMGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDRVLTQMGSPRLP 501

  Fly   521 ISSVS 525
            .||:|
Mosquito   502 CSSMS 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	70/128 (55%)
		MH2_SMAD_1_5_9	325..525	CDD:199822	152/199 (76%)
Smox	XP_318870.3	MH1	5..131	CDD:469592	69/126 (55%)
		MH2_SMAD_2_3	305..495	CDD:199826	146/190 (77%)