Protein Alignment Mad and Med

DIOPT Version :10

• Sequence 1: NP_001259992.1
• Gene: Mad / 33529
• FlyBaseID: FBgn0011648
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: XP_061498126.1
• Gene: Med / 1273058
• VectorBaseID: AGAMI1_011028
• Length: 784
• Species: Anopheles gambiae
• Alignment Length: 760
• Identity: 198/760 - (26%)
• Similarity: 283/760 - (37%)
• Gaps: 329/760 - (43%)

  Fly    75 DVESNTSSAMSTLGSLFSFTSPAVKKLLGWKQGDEEEKWAEKAVDSLVKKLKKRKGAIEELERAL 139
            |:.:..::|.::..:..|.    |..|:..:||.|.|.::::|::|||||||:::..::.|..|:
Mosquito    25 DMAAMPTAAPTSADACLSI----VHSLMCHRQGGESEGFSKRAIESLVKKLKEKRDELDSLITAI 85

  Fly   140 SCPG-QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKE 203
            :..| .|||||||.|:|||||||:.|||.|||||.|:||||||.. :|||.::.||:.|..|...
Mosquito    86 TTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHK-NELKHVKFCQFAFDLKCDS 149

  Fly   204 VCINPYHYKRVESPVL----------PPVLVPRHSEFAPG------------------------- 233
            ||:|||||:||.||.:          |..|:  ..|:.||
Mosquito   150 VCVNPYHYERVVSPGIDLSGLTLQSGPSRLI--KDEYTPGSVVGGGMDIDGNEIGTIQHHPSMVA 212

  Fly   234 ----------------------------------------------------------------- 233
                                                                             
Mosquito   213 SGAYGTMSMHPQVPDPSQLGSLYGASSGPRPIPKLESADPSRNSGPSSWMSGAGSVGGPSSAAAA 277

  Fly   234 -----------HSML---------------------------------QFNHVAEPSMPHNVSYS 254
                       |:.|                                 |.:...:||...|...:
Mosquito   278 MLSASSGGQQQHARLSSSLPLSSVIGGPPGMVNNGLRAPPSSQQQPQQQPSQQPQPSSQSNAQLT 342

  Fly   255 NSGFNSHSLSTS----------------------------------NTSVGSPSSVN-----SNP 280
            |.|.|....|:|                                  .|.:|.|:|::     ::|
Mosquito   343 NGGSNGLLGSSSQAGGSGGSSGGGLLGTDGSQYYTSAADPSMGNDPQTGMGGPASMSGSLSATSP 407

  Fly   281 NSPY-------------DSLAGTP----------------------------------------- 291
            .||:             .:.||.|
Mosquito   408 VSPHLQQNGYVSASNGQSAQAGGPAGGQAQPSQSAAQQYQPQQQQQQQQQQQPQSQQQQQQQQQQ 472

  Fly   292 ----------------------PPA----------------YSPSEDGNSNN----PN------- 307
                                  |||                |.|...|.|::    |:
Mosquito   473 QQQSGSATWSGSNTLNYTQSIQPPAHASGSHQQQASQQQSQYWPHGSGGSSSAVVAPSGASVGNA 537

  Fly   308 DGGQLLDAQMGDVAQVS-YSEPAFWASIAYYELNCRVGEVFHCNNN--SVIVDGFTNPSNNSDRC 369
            .||||.....|....:| ...|.:|.|:||:||:.:|||:|...:|  :|.:||:.:|| ..:|.
Mosquito   538 TGGQLAGELPGQQRLLSRQPAPEYWCSVAYFELDTQVGEMFKVPSNRPNVTIDGYVDPS-GGNRF 601

  Fly   370 CLGQLSNVNRNSTIENTRRHIGKGVHL-YYVTGEVYAECLSDSAIFVQSRNCNYHHGFHP-STVC 432
            |||.||||:|....|..|.||||||.| ....|:|:..||||.::||||...:...|..| ..|.
Mosquito   602 CLGALSNVHRTEQSEKARLHIGKGVQLDLRGEGDVWLRCLSDHSVFVQSYYLDREAGRTPGDAVH 666

  Fly   433 KIPPGCSLKIFNNQEFAQLLSQSVNN--------------GFEA--------------VYELTKM 469
            ||.||..:|:|:.:: ..|..||:.|              |..|              |.:|.::
Mosquito   667 KIYPGACIKVFDLRQ-CHLQMQSLANCAQKAAQMQAAVVAGVSAVGAPRSLSAAAGIGVDDLRRL 730

  Fly   470 CTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQM 514
            |.:|:|||||||.:|.||.:..||||:|:|||..||.||:||.||
Mosquito   731 CILRLSFVKGWGPDYPRQSIKETPCWVEVHLHRALQLLDEVLHQM 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	63/123 (51%)
		MH2_SMAD_1_5_9	325..525	CDD:199822	90/222 (41%)
Med	XP_061498126.1	None