Protein Alignment Mad and smad6a

DIOPT Version :9

• Sequence 1: NP_001259992.1
• Gene: Mad / 33529
• FlyBaseID: FBgn0011648
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_001019981.2
• Gene: smad6a / 116992
• ZFINID: ZDB-GENE-011015-1
• Length: 456
• Species: Danio rerio
• Alignment Length: 403
• Identity: 119/403 - (29%)
• Similarity: 180/403 - (44%)
• Gaps: 75/403 - (18%)

  Fly   105 KQGDEEEKWAEKAVDSLVKKLKKRKGAIEELERALSCPGQPSKCVTIPRS---LDGRLQVSHRKG 166
            |.|...|:..:|...:.:||||. |.....||...|..|.||.||.:.::   :.|.| ||
Zfish   120 KTGAVTEQELKKCTYAFLKKLKD-KSLDVLLEAVESQGGMPSGCVLVSQTEVRIGGHL-VS---- 178

  Fly   167 LPHVIYCRVWRWPDLQSHHELKPLELCQYPFSAKQKE-VCINPYHYKRVESPVLPPVLVPRHSEF 230
             |..:.||::|||||:....||||..|| .|.|:..: :|.||:||.|:..||......|.:|..
Zfish   179 -PQYLLCRLFRWPDLRLSSLLKPLCHCQ-SFRAEDSQTLCCNPHHYSRLCGPVKDDTPPPPYSHL 241

  Fly   231 A--PGHSMLQFNHVAEPSMPHNVSYSNSGFNSHSLSTSNTSVGSPSSVNSNPNSPYDSLAGTPPP 293
            :  |.|..|   :.:.|.:|:..:.:.......|...|:.|: ||||:..|
Zfish   242 SPLPEHKPL---NSSLPMLPYIETEATRSAGGLSQDYSDASM-SPSSLAQN-------------- 288

  Fly   294 AYSPSEDGNSNNPNDGGQLLDAQMGDVAQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIVDG 358
                                                .|.::||:||..|||.::..::.|:.: .
Zfish   289 ------------------------------------HWCNVAYWELRTRVGRLYPVHDASLSI-F 316

  Fly   359 FTNPSNNSDRCCLGQLSNVNRNSTIENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRNCNYH 423
            :..|....  .|||.|....|:::::.||..||.|:.|......|:|...|...|||.|.... |
Zfish   317 YDLPQGTG--LCLGLLPLSPRSTSVQRTRGKIGHGILLSKEPDGVWAYNRSQHPIFVNSPTLE-H 378

  Fly   424 HGFHPSTVCKIPPGCSLKIFNNQEFAQLLSQSVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQD 488
            |.:...||.::.||.|:|:|:.::..|:...|.....|..|:..   ::|:||.||||..|.||.
Zfish   379 HPYLSLTVRRVMPGYSIKVFDYEKSCQMQPASHPVHPEGPYDPN---SVRISFAKGWGPCYSRQF 440

  Fly   489 VTSTPCWIEIHLH 501
            :||.|||:||.|:
Zfish   441 ITSCPCWLEILLN 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	43/114 (38%)
		MH2_SMAD_1_5_9	325..525	CDD:199822	59/177 (33%)
smad6a	NP_001019981.2	MH1_SMAD_6	118..229	CDD:199817	43/116 (37%)
		MH2	281..454	CDD:294046	64/230 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3701
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810