Protein Alignment Mad and smad6

DIOPT Version :9

• Sequence 1: NP_001259992.1
• Gene: Mad / 33529
• FlyBaseID: FBgn0011648
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: XP_004912726.1
• Gene: smad6 / 100038072
• XenbaseID: XB-GENE-481307
• Length: 357
• Species: Xenopus tropicalis
• Alignment Length: 400
• Identity: 112/400 - (28%)
• Similarity: 168/400 - (42%)
• Gaps: 102/400 - (25%)

  Fly   117 AVDSLVKKLKKRK--GAIEELERALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWP 179
            |..:::|:||::.  ..:|.:|...:.||   .||.:.|         |... ||::.||::|||
 Frog    42 AASAILKRLKEQALCALLEAVESRGAAPG---GCVCVTR---------HGPP-PHLLLCRLFRWP 93

  Fly   180 DLQSHHELKPLELCQYPFSAKQKEVCINPYHYKRVESPVLPPVLVPRHSEFAPGHSMLQFNHVAE 244
            :||...:||.|..||....::...||.|||||.||..|..||   |.:|..:|        .:.:
 Frog    94 ELQHPGQLKALCGCQGAGGSENNSVCCNPYHYSRVCGPESPP---PPYSRLSP--------KIEQ 147

  Fly   245 PSMPHNVSYSN-SGFNSHSLSTSNTSVGSPSSVNSNPNSPYDSLAGTPPPAYSPSEDGNSNNPND 308
            ..:..:.||:. ...||..::..:.|..|.|:.:.:|:
 Frog   148 KPLDLSDSYTEMEASNSLCITAGDISGTSASNTSLSPD--------------------------- 185

  Fly   309 GGQLLDAQMGDVAQVSYSEPAFWASIAYYELNCRVGEVFHCNNNSVIV-------DGFTNPSNNS 366
                            .|:...|.|:||:|...|||.::.....||.:       .||
 Frog   186 ----------------MSKQGHWCSVAYWEHRTRVGRLYAVCQPSVSIFYDLPQGSGF------- 227

  Fly   367 DRCCLGQLSNVNRNSTIENTRRHIGKGVHLYYVTGEVYAECLSDSAIFVQSRN-----CNYHHGF 426
               |||||:..||:.....||..||.|:.|......|:|...||..|||.|..     |
 Frog   228 ---CLGQLNLENRSEAAARTRGKIGLGIVLSREADGVWAYNRSDHPIFVNSPTLDAPAC------ 283

  Fly   427 HPSTVCKIPPGCSLKIFNNQEFAQLLSQ-SVNNGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVT 490
            .|..|.|:.||.|||:|:.::...|... :.....:..|:   ..::|:||.||||..|.||.:|
 Frog   284 RPLVVRKVMPGYSLKVFDYKKSCVLRHHPTPPEHTDGPYD---PHSVRISFAKGWGPCYSRQMIT 345

  Fly   491 STPCWIEIHL 500
            |.|||:|:.|
 Frog   346 SCPCWLEVLL 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mad	NP_001259992.1	MH1_SMAD_1_5_9	93..216	CDD:199814	35/100 (35%)
		MH2_SMAD_1_5_9	325..525	CDD:199822	62/188 (33%)
smad6	XP_004912726.1	MH1_SMAD_6	27..132	CDD:199817	35/102 (34%)
		MH2_SMAD_6	183..357	CDD:199824	63/234 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000