DRSC/TRiP Functional Genomics Resources

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Protein Alignment itgb4 and DIP-delta

DIOPT Version :9

Sequence 1:XP_005166847.1 Gene:itgb4 / 335269 ZFINID:ZDB-GENE-030131-7209 Length:1931 Species:Danio rerio
Sequence 2:NP_001097508.2 Gene:DIP-delta / 5740816 FlyBaseID:FBgn0085420 Length:469 Species:Drosophila melanogaster


Alignment Length:356 Identity:82/356 - (23%)
Similarity:127/356 - (35%) Gaps:94/356 - (26%)


- Green bases have known domain annotations that are detailed below.


Zfish  1227 YVTQTATSP-----GG-RLYSPANIKAVATGPKNIRLNWKPSQN------ANGYKVK--YWIYGD 1277
            |:.|..|:|     |. ::..|.||..:.:.|.::.:  :.:||      |:|:...  .|...|
  Fly   123 YMCQVNTNPMISQVGYLQVVVPPNILDIESTPSSVAV--RENQNINMTCRADGFPAPKIIWRRED 185

Zfish  1278 PEDKA--KFMDVKTPQAELTNLDPYCDYEMRVCGYNALGDGNYSDIIQCQTLEDIPGEPG-RLAF 1339
            .|:.|  |...|....|::..|......||          |.|    .|.....:|.... |:..
  Fly   186 GEEIAVEKKKKVLVYDADVLPLTKVSRNEM----------GAY----LCIATNGVPPSVSKRIIL 236

Zfish  1340 NV-ISPTVTQVSWAEPAEANGIITGYEV-------------IYMPINEDKKPTGPPKKVMIDNPK 1390
            :| .||.:    |. |.:..|..:|.:|             ||...|  .....|.||...|..:
  Fly   237 DVEFSPMI----WV-PNQLVGAPSGTDVTIDCHTEAHPKAIIYWVYN--SVMVLPSKKYKTDYTE 294

Zfish  1391 K-----RMLLIENLQPSQTYCYKVRASNKVG--WGPYREATINLASQPTRPMSIPIIPDIPIVDA 1448
            .     ..|.|.|||......|:..:.|.:|  .|..|...|.|.|.|::.::...:        
  Fly   295 NSYRAHMKLTIRNLQYGDFGNYRCISKNSLGETEGSIRVYEIPLPSTPSKQVTHTTV-------- 351

Zfish  1449 EAGEEYDSYLMYSNEVLRSPTSSLRPSVTDLSDDQFVNGKWEQNFLFPGGGGGSLSRNISSSSTT 1513
               |..::.::.|:.  ...|.||:..|          |...:|.|:||....|.|.  .|||..
  Fly   352 ---ESRENNIIPSSR--NDTTKSLQTDV----------GYAMKNDLYPGSASSSSSG--GSSSAA 399

Zfish  1514 YSHSTPRTN-----VTNNSSTTTYISGKGGS 1539
            .|.|:.:|:     |..||.::   .|..||
  Fly   400 SSSSSMQTSALPGGVAGNSLSS---MGSKGS 427

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
itgb4XP_005166847.1 Integrin_beta 37..457 CDD:278776
EGF_2 <468..490 CDD:285248
EGF_2 545..573 CDD:285248
Integrin_B_tail 625..709 CDD:285239
Calx-beta 991..1064 CDD:295344
FN3 1242..1326 CDD:238020 21/93 (23%)
FN3 1331..1420 CDD:238020 26/110 (24%)
fn3 1640..1720 CDD:278470
fn3 1751..1835 CDD:278470
DIP-deltaNP_001097508.2 IG 51..143 CDD:214652 5/19 (26%)
Ig 145..238 CDD:416386 22/108 (20%)
Ig strand A 145..149 CDD:409353 2/3 (67%)
Ig strand A' 154..159 CDD:409353 1/4 (25%)
Ig strand B 165..172 CDD:409353 0/6 (0%)
Ig strand C 178..183 CDD:409353 1/4 (25%)
Ig strand C' 185..187 CDD:409353 1/1 (100%)
Ig strand D 195..199 CDD:409353 1/3 (33%)
Ig strand E 203..209 CDD:409353 1/5 (20%)
Ig strand F 216..223 CDD:409353 3/10 (30%)
Ig strand G 230..238 CDD:409353 1/7 (14%)
Ig 242..333 CDD:416386 22/97 (23%)
Ig strand A' 250..253 CDD:409353 0/2 (0%)
Ig strand B 259..266 CDD:409353 1/6 (17%)
Ig strand C 272..277 CDD:409353 2/4 (50%)
Ig strand C' 281..283 CDD:409353 0/1 (0%)
Ig strand D 289..293 CDD:409353 1/3 (33%)
Ig strand E 295..305 CDD:409353 1/9 (11%)
Ig strand F 314..322 CDD:409353 1/7 (14%)
Ig strand G 325..334 CDD:409353 3/8 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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