DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment itgb4 and dpr3

DIOPT Version :9

Sequence 1:XP_005166847.1 Gene:itgb4 / 335269 ZFINID:ZDB-GENE-030131-7209 Length:1931 Species:Danio rerio
Sequence 2:NP_001014459.2 Gene:dpr3 / 3346208 FlyBaseID:FBgn0053516 Length:522 Species:Drosophila melanogaster


Alignment Length:325 Identity:63/325 - (19%)
Similarity:102/325 - (31%) Gaps:131/325 - (40%)


- Green bases have known domain annotations that are detailed below.


Zfish   226 NLDAPEGGFDAILQTAV--CQDQ-IGW-RKDSTHLLVFST------------------ESAFHYE 268
            |:....|..:||::..|  ..|: :.| ||...|:|...|                  |...|.:
  Fly   245 NITGRTGHTEAIIKCRVDSLHDKSVSWIRKRDLHILTVGTATYTSDKRFQVTESKDSREWTLHVK 309

Zfish   269 ADGANVLAGILDRNDEQCHLNVDGNYTH-------DVRQDYPSI----PTL---------VRLLV 313
            |..|.      |....:|.:|.:...:.       ::..|..::    |.|         :..||
  Fly   310 APLAK------DSGIYECQVNTEPKMSMAFQLNIIEISPDAKAVISGPPDLHFKAGSAIILNCLV 368

Zfish   314 KH----NIIPIFAVTNHSYSYYEKLHEYFPI-AELGQ-------------LQEDSSNILSILEKA 360
            :.    :|.||:        :|...|...|. |:.||             :.||:|.        
  Fly   369 QQPSVKDIGPIY--------WYRGEHMITPFDADDGQPEIPAGRGEHPQGIPEDTSP-------- 417

Zfish   361 FENIRSKISIRAEDRPK-AVETKIFSQSGTFSEYGNFKITPGQTGKFKVRMKALNQVGEEPVCKV 424
             .:|.|::.::.|...: |:|:::                 |.|.|.::|:...           
  Fly   418 -NDIMSEVDLQMEFATRIAMESQL-----------------GDTLKSRLRISNA----------- 453

Zfish   425 NQADRAGTLRVKPTTFSSAFKINAEVLCPTCDCEKTPVKNAVRCTGHGDLVCGKCQCYAGWLGPL 489
             |....|....:|||.||     |.||....:.|.......          .|.|.|.   ||||
  Fly   454 -QTTDTGNYTCQPTTASS-----ASVLVHV
INDENPAAMQK----------SGACPCA---LGPL 499

Zfish   490  489
              Fly   500  499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
itgb4XP_005166847.1 Integrin_beta 37..457 CDD:278776 55/291 (19%)
EGF_2 <468..490 CDD:285248 7/22 (32%)
EGF_2 545..573 CDD:285248
Integrin_B_tail 625..709 CDD:285239
Calx-beta 991..1064 CDD:295344
FN3 1242..1326 CDD:238020
FN3 1331..1420 CDD:238020
fn3 1640..1720 CDD:278470
fn3 1751..1835 CDD:278470
dpr3NP_001014459.2 Ig 243..330 CDD:299845 19/90 (21%)
IG_like 243..329 CDD:214653 19/89 (21%)
Ig 350..464 CDD:299845 27/159 (17%)
IG_like <441..477 CDD:214653 14/52 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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