DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toc and Mtus2

DIOPT Version :9

Sequence 1:	NP_477153.1	Gene:	toc / 33526	FlyBaseID:	FBgn0015600	Length:	2162	Species:	Drosophila melanogaster
Sequence 2:	NP_001346432.1	Gene:	Mtus2 / 77521	MGIID:	1915388	Length:	1353	Species:	Mus musculus

Alignment Length:	1692	Identity:	356/1692 - (21%)
Similarity:	575/1692 - (33%)	Gaps:	568/1692 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   412 NLTKSVIEPGDFTKVIHQGANLTLSMDQLPLLEHISMPSGLDILSSKCSGNVERPSQETDDTLDV 476
            |..:|::..||            .:.:|: :||          :||.|.   |..|::.||.|
Mouse    24 NNNESILRTGD------------TNANQI-MLE----------VSSSCD---EAKSRDLDDEL-- 60

  Fly   477 TLTSLAPDKTNMKLP-LNSTLNTERLLDISALQSPRHIQ------LLNLTQELERGTPSRVHLQ- 533
                   ..:|:..| .:|....|          |.|:|      ....|.:.|......||.|
Mouse    61 -------GNSNLSRPQYHSHFQKE----------PLHLQGFGKGSQAGSTSQRESQASLTVHRQL 108

  Fly   534 -------SGRRSMPQHSLLCLSPQSATTTPHGMRMMGQATPQ---------PVH---------LL 573
                   .|....||    |:...|.::..:.   :|||:|:         |.|         |.
Mouse   109 SEEHAVKRGALQAPQ----CVQGPSLSSWRNA---VGQASPEASAKKDAEIPRHIPKDKLAKTLD 166

  Fly   574 SPLLKQAQSALVL-----------------------------PTRTP----------DGDITMDG 599
            :..||:|.|....                             |.|||          .|:.|.:|
Mouse   167 NEELKRASSCSAAAGSVPPTDLQPVQLDTLGPQDHVPARGEGPQRTPASHSPGKGFSPGEGTSEG 231

  Fly   600 NG----------ALDSTLTSTSVRGRTRYSFGLDLPDTTLDCSIELVDNSFSSSTQLQQLQQQLL 654
            |.          |..|:.:.|.:.|    ..|||:.:..: ...||..:|.|:|
Mouse   232 NSVYLPKPSTSEAKGSSPSDTKMEG----PHGLDVYNERI-THAELTPSSASAS----------- 280

  Fly   655 KKQSSFDLDESLGILTPDQMKDFLDSPHNNLMHNLEMIRMHHPNLLQLRMEQTPS-PEELPLDPI 718
                    .|:.|:..|:..   |..........|:.::..:...|.....|.|. .||..:.|:
Mouse   281 --------KENPGLRHPEVC---LGQGTGKSKVELKSVQPRNEEGLTSAQAQGPGCHEERSMSPV 334

  Fly   719 EIKSEIVKQVEASQNQVNTSQHSKLSNSFITSVTSVTSLDTGYQGDGE-----MSRPASRGACDH 778
            |.:..:.|....:.:|.|:| |.:|.....:|:..:|.:..|.:|..:     .:.||.......
Mouse   335 ERQELLEKAYREATSQGNSS-HRQLGVRRGSSLEEMTGVSAGVEGSQQATPTLSAAPAGEAGTRL 398

  Fly   779 SPSNGPHLGRVSRQPSFPPPNP-----APLRRQDPMTDSDFFTESDADDVLHRGDRRAQVIDGQL 838
            :......:||::|:.:.....|     ||:|| ||       |||...:|  .|:.| ::..|..
Mouse   399 TGKMSAGVGRMARETASGQTAPDVGQAAPVRR-DP-------TESVPSEV--SGEER-RLGSGNS 452

  Fly   839 YGPDMMQPSASVPQMEDSCMESSGIFTDVENRCDEEMRQPELEFDVDMDMSPDDSSQTMRKGQGQ 903
            ....::   ||.|....|..::||:                        :||..|:...|||:..
Mouse   453 GSTKLL---ASGPSAGGSRTDTSGL------------------------LSPRGSNLEARKGKEM 490

  Fly   904 PISTQQQQNQLAPQQRPPSSCLSSSSAATTLSQSLSNRTSYCSVDGGSARSFCGDEAFAAGRSTT 968
            ....:......|.....|:..                                 |.||
Mouse   491 VAENRNLLENAAQTDNTPAGV---------------------------------DSAF------- 515

  Fly   969 TTAAAAAAAALSVQKTTSPRPHASLSSLCTVENFRGSVSSNSSIASPKSCKSSVTKTSAGKSRVL 1033
            :|.|.......:|..:..|.|..|.|....|  |.|...| .|:|||.:....|..|
Mouse   516 STPAPLLHPETTVNSSHHPTPPGSSSQELGV--FSGDTGS-PSVASPPTDGGQVLNT-------- 569

  Fly  1034 KSPKSPKS-------PKSPLNRKAHTPNKWDA-------VMNKIASNKSLIKTNYNDVKSKVSTT 1084
             |||.|..       ||.|.:.| .||:..:|       .|.:.|..|.::......|:.|:.|.
Mouse   570 -SPKVPDRTTCSSGIPKPPTHPK-DTPSSQEAREKLETEKMEERAEAKPILMPKPKHVRPKIITY 632

  Fly  1085 RIMTP---ASGSSPVSGSGSGSVSRTASSPRASPSVSASARRSPSAT-----------PKVPPKM 1135
            ....|   :.|.:.:...|......|...|......:||....|||.           |:|.|..
Mouse   633 IRRNPQALSQGDASLVPVGLPYAPPTCGMPLPQEEKAASRDLQPSANMYEKLKPDLQKPRVFPSG 697

  Fly  1136 LLA---KRP----SSSSGK----VNATP------SPP--PHATPPT---RQPLDKGSVGAGSVGG 1178
            |:.   |.|    |..|.|    |...|      |||  .:..|||   ...|.|..:|.|::.
Mouse   698 LMVSGIKPPAHHFSQMSEKFLQEVADHPGKEEFCSPPYTHYEVPPTFYRSAMLLKPQLGLGAMS- 761

  Fly  1179 GGARAVKTPKSPT-----SPTTPTTPTSPPAKRLQTSLVSRGRSYSKDSHKSSHTDLSLMCNASS 1238
                  :.|.:.:     |..:..:...||.     ||.:....|..|.     :||....|:::
Mouse   762 ------RLPSTKSRILIASQRSSASAIHPPG-----SLTTAASFYGSDP-----SDLKKASNSNA 810

  Fly  1239 SRPSNSASGSGSPKLLANTQLRAAKKRD---VRNLSISPTDLGPPPKTQQTTKGQSTRSKSSATP 1300
            ::.|...||...|   ..::|.|||...   ||:.|||..     |.:|.....|..:|:
Mouse   811 AKASLPKSGLRPP---GYSRLPAAKLAAFGFVRSSSISAV-----PSSQSLDSVQPEQSR----- 862

  Fly  1301 TPTPTSIHKRLNGTLASTAAIATPIKGVATKSGATNK----LQQSAKTKST---ASIKSPAIVGV 1358
                                   |:    |:|...|:    |:|:..:|.|   |...:||
Mouse   863 -----------------------PV----TRSTFGNEEQAPLKQALPSKDTPKGAGRAAPA---- 896

  Fly  1359 SEESLRSGVDQTELQELNNGQSATGCPTPPMARDSKRTSIGNELPCETEAKLKRCEDQQDPQAST 1423
                                 |::...||      :|:.:.......|.|..|: |.|:||:|..
Mouse   897 ---------------------SSSNATTP------RRSLLPAPKSTSTPAGAKK-ELQKDPEAKK 933

  Fly  1424 TASPLPMINPQEQEASGQVKEATITTANEPNALSLPDEISNSVSSTTMLATPRVDIAAQYPVLKP 1488
            .|...|              :.|.:.|.:|::...|.:.:::         ||    .::|. ||
Mouse   934 PAVSSP--------------KRTASAATKPHSPGYPKQRTSA---------PR----NEFPP-KP 970

  Fly  1489 FTENGELDCARLAKFFQDTQFERKEEQRQILGLSVMVQFMSKEL-------DAVACKENKHQCAR 1546
            ..:..|.: .:||:..:|    |.|.|.:.|||:      .:||       ||:|. ..||...:
Mouse   971 DLQAREAE-RQLAQRLRD----RCEWQARQLGLA------RRELKKAIQGFDALAV-STKHFFGK 1023

  Fly  1547 TKGTLEKTILLLQHTQKDCERLREDLEDKGLEWIQRQQEKEYLHRTELKQAEEKLMEVQLRAKLK 1611
            ::..|.|.    :....:...:|:::.....:..:.|:|||.|.|    :.||:|..:..:.:.:
Mouse  1024 SERALAKE----KELSIELANIRDEVAFNTAKCEKLQKEKETLER----RFEEELRRLGWQQQAE 1080

  Fly  1612 FCELESQLRAKDEESKQAQEAYRMEVSHK---LALKQEHLRTAEQKIQELQTRLQQVETEEQGHR 1673
            ..||:.:|    ::..||:.| |::..|:   |.::.:|        ||      |||.....|.
Mouse  1081 VQELQERL----QQQFQAESA-RLQAEHQDQLLRMRCQH--------QE------QVEDITASHE 1126

  Fly  1674 EELIRKENIHTARLA----EANQREQDLIDRVKSLTKELNTLKANKEHNERDLRDRLALSQDEIS 1734
            ..|:..||.||..:.    :.:.:.|:|:...:...|||       |.|...||..|   ||::.
Mouse  1127 AALLEMENNHTVAITILQDDHDHKVQELMSTHEFEKKEL-------EENFEKLRLTL---QDQVD 1181

  Fly  1735 VLRTSSQRRSPCTSLPDNAS------------------AELNRLTSEADSLRCVLELKQAEISAL 1781
            .|...||      ||.|.|.                  |....|..:..||:.|||:|..:|...
Mouse  1182 TLTFQSQ------SLRDRARRFEEALRKTTEEQLEIALAPYQHLEEDMQSLKQVLEMKNQQIHLQ 1240

  Fly  1782 SKAKADLIHESEERLKLSNRVALLEAQNEMLRTELEAKTEKEKEIQQKMEELQKAYKYESIKRTR 1846
            .|...:|....|:.:.|..|:.:|:.|||.|:..::..|...:::.::...||:..:.|:.::.|
Mouse  1241 EKKIIELEKLVEKNIILEERIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKR 1305

  Fly  1847 LTYDKEELQYHLKQRSLQLQSAESKLQDLSTGSHDNSLSSHSRCSLGRSGLEIAVTTSSPTSPVM 1911
            |:...|||                 |..|.||...:.:.                  .||||||.
Mouse  1306 LSRTNEEL-----------------LWKLQTGDPTSPIK------------------LSPTSPVY 1335

  Fly  1912 KG 1913
            :|
Mouse  1336 RG 1337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toc	NP_477153.1	DUF390	<1302..1737	CDD:282014	96/455 (21%)
		RILP-like	<1550..1668	CDD:304877	27/120 (23%)
		COG1340	1580..1850	CDD:224259	74/294 (25%)
		YlqD	1642..>1712	CDD:287979	17/73 (23%)
		DUF4795	1652..1826	CDD:292662	50/195 (26%)
Mtus2	NP_001346432.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..101		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	125..259		24/140 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..615		91/454 (20%)
		Atrophin-1	<309..677	CDD:331285	94/459 (20%)
		Atrophin-1	<516..974	CDD:331285	127/587 (22%)
		Mediates interaction with MAPRE1. /evidence=ECO:0000250	626..964		92/453 (20%)
		Localization to the growing distal tip of microtubules. /evidence=ECO:0000250	786..1134		104/496 (21%)
		Sufficient for interaction with KIF2C. /evidence=ECO:0000250	786..874		28/137 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	799..823		6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	847..972		38/221 (17%)
		SMC_N	1024..>1313	CDD:330553	78/331 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1315..1353		10/41 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I8467
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	82	1.000	Inparanoid score	I5183
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto93202
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24200
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7318
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.090