DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toc and mtus1a

DIOPT Version :9

Sequence 1:	NP_477153.1	Gene:	toc / 33526	FlyBaseID:	FBgn0015600	Length:	2162	Species:	Drosophila melanogaster
Sequence 2:	XP_005157297.1	Gene:	mtus1a / 563853	ZFINID:	ZDB-GENE-061103-409	Length:	1112	Species:	Danio rerio

Alignment Length:	1313	Identity:	291/1313 - (22%)
Similarity:	483/1313 - (36%)	Gaps:	368/1313 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   738 SQHSKLSNSFITSVTSVTSLDTGYQG---DGEM----SRPASRGACDHSPSNGPHLGRVSRQPSF 795
            |:||      :.|:.|.|||..|...   |.||    :.||.   |:.|.:|   |.:..|  :.
Zfish    26 SEHS------LDSLRSSTSLSCGGSDSPPDVEMKDCLTCPAK---CETSSAN---LAKSCR--TI 76

  Fly   796 PPP---------------NPAPLRRQDPMTDSDFFTESDADDVLHRGDRRAQVIDG--------- 836
            |..               ||...:..|..::|  |.|.        |||....:|.
Zfish    77 PVDLKLDNWKENLTLLIVNPKHTQSSDGGSES--FPEC--------GDREMSEVDSSEPSRRGSS 131

  Fly   837 ----QLYGPDMMQPSASVPQMEDSCMESSGIFTDVENRCDEEMRQPELEFDVDMDMSPD------ 891
                .:...:||..|.|:...|...:.|..:..|.:|..|...     :|.|...|.||
Zfish   132 ENCCSVSSGEMMMRSNSLLVHETDQLLSISLIGDSKNSLDVSS-----DFGVISGMLPDVCEGLA 191

  Fly   892 DSSQTMRKGQGQPISTQQQQNQ--LAPQQRPPSSCLSSSSAATTLSQSLSNRTSY---CSVDGGS 951
            :..:...|.|....:..||.||  |..::    |.:......|.:....||:...   |:. |||
Zfish   192 EFPKEEVKSQMLECTYIQQNNQTFLIDER----SSVEKLECVTPVQYYKSNKDVQKLACNT-GGS 251

  Fly   952 ARSFCGDEAFAAGRSTTTTA---------AAAAAAALSVQKTTSPRPHASLSSLCTVENFRGSVS 1007
            ..|       |.|::...||         |..:....||...|...|..|.|.|
Zfish   252 NHS-------AEGKTVLLTACEDLDISGNAQTSTPVQSVSNKTFCLPSLSESPL----------- 298

  Fly  1008 SNSSIASPKSCKSSVTKTSAGKSRVLKSPKSPKSPKSPLNRKAHTPNKWDAVMNKIASNKSLIKT 1072
             |....||   .::|::.|..|..|.:.||:..| ||                ||| ..|...|.
Zfish   299 -NKDEVSP---VAAVSQKSESKCAVSQKPKTSAS-KS----------------NKI-EIKRFPKP 341

  Fly  1073 NYNDVKSKV--------STTRIMTPASGSSPVSGSGSGSVSRTASSPRASPSVSASARRSPSATP 1129
            |::::|||:        .||....|.:.||.|..:..   |:.....::||:.|||...|.:.:.
Zfish   342 NFSNIKSKIMSRASNPFKTTNAQVPKTTSSSVCQTNE---SQDTDQCKSSPNKSASTTVSNAPSV 403

  Fly  1130 KVPPKMLLAKRPSSSSGKVNATPSPPPHATPPTRQPLDKGSVGAGSVGGGGARAVKTPKSPTSPT 1194
            |   ....|||..:|:    ...|.|...|.|.|.. :.||            :.||.|..|...
Zfish   404 K---SFTAAKRTRTST----CQESGPASKTRPRRWS-ESGS------------SSKTSKDGTQEK 448

  Fly  1195 TPT-----TPTSPPAKRLQ-TSLVSRGRSYSKDSHKSSHTD---------------LSLMCNASS 1238
            :|.     :....|.|.:: .|....|:|...|..:::..|               :||:  |.|
Zfish   449 SPQVNGVFSNLITPRKNIKGCSQNQSGKSKPLDKQETTREDGQGNESQKVRGKNPRISLL--AVS 511

  Fly  1239 SRPSNSASGSGSPKLLANTQLRAAKKRDVRNLSISPTDLGPPPKTQQTTKGQSTRSKSSATPTPT 1303
            :||:.:|....|...| ..|...|:........:...:|.||....:...|.:.|..|||..||:
Zfish   512 ARPAAAAVCEWSRGRL-GPQPSPARTGGAAAAHVPAANLRPPLSASKIKPGAAGRDGSSANGTPS 575

  Fly  1304 PTSIHKRLNGTLASTAAIATPI-KGVATKSGATNK-LQQSAKTKSTASIKSPAI-VGVSEESLRS 1365
            |    ||...|  ....:..|: :|.:|.||:.:: ...||.|.::.....|.| :..|..|..|
Zfish   576 P----KRKLST--PDVKLKVPLTEGASTVSGSQSRPAVFSAPTSASKLPVKPKIQLKSSSASQPS 634

  Fly  1366 GVDQTELQELNNGQSATGCPTPPMARDSKRTSIGNELPCETEAKLKRCEDQQDPQASTTASPLPM 1430
            |..:.:.:|.:.|..:   .||    .::.|...::|.|.
Zfish   635 GQPKQDHEEPSVGSLS---KTP----SNRATYFRSKLQCP------------------------- 667

  Fly  1431 INPQEQEASGQVKEATITTANEPNALSLPDEISNSVSSTTMLATPRVD-----IAAQYPVLKPFT 1490
              |....:|...|.|:.::::...:.|.|.:.|.:.......|||.||     .:::.|  :|.|
Zfish   668 --PTRNASSAGCKNASTSSSSSVRSSSSPLKTSITPRPVKTAATPTVDKNKSRTSSKNP--QPPT 728

  Fly  1491 ENGELDC------ARLAKFFQDTQFERKEE------------QRQILGLSVMVQFMSKELDAVAC 1537
             ||:.|.      :|..:::: .|.|:|.:            .|:...::|:::.:..|.|.|
Zfish   729 -NGQPDLVPPESKSRNVEYYK-AQCEKKNQTIRQLENTLLSNNRRFEAVAVVIKHLYAEHDEV-- 789

  Fly  1538 KENKHQCARTKGTLEKTILLLQHTQKDCERLREDLED-----KGLEWIQRQQEKEYLHRTELKQA 1597
            .:.:...::...||.:.::...|:   ||||.::.||     .|:  :|:.||:   ||.:|...
Zfish   790 MKQRRDLSQELVTLREELVSSGHS---CERLEQEKEDLRSAFDGV--LQKVQEQ---HRLDLADL 846

  Fly  1598 EEKL------------MEVQLRAKLKFCELESQLRAKDEESKQAQEAYR--MEVSHKLALKQEHL 1648
            ||:|            ...|..|.....::|.||    ||.:...||.:  :|.||
Zfish   847 EERLKTFYSTEWEKVHQAYQEEADKCKAQMEQQL----EEIRSKHEALKKELEFSH--------- 898

  Fly  1649 RTAEQKIQELQTRLQQVETE----EQGHREELIRKENIHTARLAEANQREQDLIDRVKSLTKELN 1709
                  |:|:....||.|..    :|.|.:|:   :|::..    ..:.|:.|.::::.|..|.:
Zfish   899 ------IEEVGGLKQQFEESFKGFKQSHEKEM---QNLNET----LKESEETLYNQIQDLMTEND 950

  Fly  1710 TLKANKEHNERDLRDRLAL---SQDEISVLRTSSQRRSPCTSLPDNASAELNRLTSEADSLRCVL 1771
            :|   ||....:::.|:.|   :||..::.                       |..|.:||:.||
Zfish   951 SL---KEKLNAEVKRRMELAEKTQDSHTLY-----------------------LEQELESLKVVL 989

  Fly  1772 ELKQAEISALSKAKADLIHESEERLKLSNRVALLEAQNEMLRTELEAKTEKEKEIQQKMEELQKA 1836
            ::|..:|....|....:....|..:||...:..|:.:||.|:..::......:::..:...||::
Zfish   990 DIKNKQIHEQDKKLMQIDKLMERNVKLDECLKKLQQENEDLKARMDRHAALSRQLSTEQAVLQES 1054

  Fly  1837 YKYESIKRTRLTYDKEELQYHLKQRSLQLQSAESKLQDLSTGSHDNSLSSHSRCSLGRS-GLEIA 1900
            .:.||....||:.:.|||.:.|                     |:..|:|..:.|...| .|:..
Zfish  1055 LQKESKVNKRLSMENEELLWKL---------------------HNGDLTSPRKISPSPSLNLQSP 1098

  Fly  1901 VT----TSSPTSP 1909
            .|    :|.|.||
Zfish  1099 RTSGMFSSPPVSP 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toc	NP_477153.1	DUF390	<1302..1737	CDD:282014	104/486 (21%)
		RILP-like	<1550..1668	CDD:304877	36/136 (26%)
		COG1340	1580..1850	CDD:224259	63/290 (22%)
		YlqD	1642..>1712	CDD:287979	13/73 (18%)
		DUF4795	1652..1826	CDD:292662	36/180 (20%)
mtus1a	XP_005157297.1	BAR	752..936	CDD:299863	47/219 (21%)
		Apolipoprotein	787..999	CDD:279749	61/273 (22%)
		VIP2	857..1087	CDD:294115	61/302 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007314
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24200
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010