DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toc and mtus2a

DIOPT Version :9

Sequence 1:	NP_477153.1	Gene:	toc / 33526	FlyBaseID:	FBgn0015600	Length:	2162	Species:	Drosophila melanogaster
Sequence 2:	XP_005155337.1	Gene:	mtus2a / 556195	ZFINID:	ZDB-GENE-091204-75	Length:	1303	Species:	Danio rerio

Alignment Length:	1377	Identity:	286/1377 - (20%)
Similarity:	470/1377 - (34%)	Gaps:	404/1377 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   717 PIEIKSEIVKQVEASQNQVNTSQHSKLSNSFITSVTSVTSLDTGYQGDGEMSRPASRGACDHSPS 781
            |:::::...:  ..:...:...:....||.|.:|:::||||      .|.::.......|
Zfish   143 PLDLRTSSSR--SGANRTLRDGRSGSESNVFSSSLSAVTSL------SGSLASALDTAGC----- 194

  Fly   782 NGPHLGRVSRQP---SFPPPNPAPLRRQDPMTDSDFF-TESDAD-----DVLHRG---DRRAQVI 834
                     .||   .|........|.|.|.|...|. :|.:.|     |..|..   .:..|..
Zfish   195 ---------TQPLYSQFTKSTSGKGRNQQPATTESFIHSERNRDLPRDLDQNHNSTILPQEPQYD 250

  Fly   835 DGQLYGPDMMQPSASVPQMEDSCME---SSGI----------FTDVENRCDEEMRQPELEFDVDM 886
            ..:|..|....||....::....||   ::|.          ...|:..|.:.:|....|
Zfish   251 RSKLITPSGAYPSNGTIKVHKFPMEAEQNTGYKWMSTEVPKGMVRVQPSCRQLVRPLSTE----- 310

  Fly   887 DMSPDDSSQTMRKGQGQPISTQ--QQQNQLAPQ---QRPPSSCLSSSSAATTLSQSLSNRTSYCS 946
                      .|...|.|.|.|  |||:..:..   .:...:|...:|...|.::.:.|:|
Zfish   311 ----------KRLTSGYPNSDQADQQQSHYSETCHGHQQVLACTEVNSNPNTGTEMVHNQT---- 361

  Fly   947 VDGGSARSFCGDEAFAAGRSTTTTAAAAAAAALSVQKTTSPRPHASLSSLCTVENFRGSVSSNSS 1011
                    |..:    |.|....::|..||:..|:::.|    |.|..:.       .|.|..|.
Zfish   362 --------FTRE----AQRIKRQSSADRAASPSSLERKT----HFSRRAY-------SSPSRPSP 403

  Fly  1012 IASPKSCKSSVTKTSAGKSRVLKSPKSP-----------KSP-KSPLNRKAHTPNKWDAVMNKIA 1064
            ..|||:.:|.....|:...:.|.| ::|           ::| |:.:|...|.|......|....
Zfish   404 PPSPKTTRSPQRHPSSSPIKTLPS-RAPQLGYAGYTSGLRAPVKTTINTSVHKPLAQQTSMETSP 467

  Fly  1065 SNKSLIKTNYNDVKSKVSTTRIMTPASGSSPVSGSGS--------GSVSRTASSPRA-------- 1113
            .:|.|.|.  ..|:.|:.|....||.....|:.||..        .:.|.|.:.|..
Zfish   468 PSKCLPKP--KSVRPKIITYIRKTPQVKPQPLEGSYEVSSLPTRLSTYSSTQAKPAVGDQGEASV 530

  Fly  1114 ---------------------SPSVSASARRSPSATPKVPPKMLLAKRPSSSSGKVN-------- 1149
                                 ||.:..|..:.||.|  :|.||  |.|..|..|.:|
Zfish   531 LSASNLLYDKYRQEMQKVRLFSPGLMGSGIKPPSNT--MPHKM--AGRSDSFYGSLNKPLSAAVG 591

  Fly  1150 ----ATPSPPPHATPPTRQPL---DKGS-----------VGAGSV-------GGGGARAVKTPKS 1189
                ...||...|..|:..|:   |.||           :|.|:|       ..|.......|||
Zfish   592 RSAVGLGSPVSAAEDPSGSPMGAQDTGSLFRSPRGLRPQLGVGAVNRTPSVLAKGRMTLTSHPKS 656

  Fly  1190 PTSPTTPTTPTSPPAKRLQTSLVSRGRSYSKDSHKSSHTDLSLMCNASSSRPSNSASGSGSPKLL 1254
            |.:.:.|....:|..:..|.         ::|..|...|.|:  ..:...:|:.:.||...|...
Zfish   657 PLTISQPMQAVNPTTQTPQE---------TQDQRKPVSTGLA--AKSLLPKPAQAQSGLRPPGYS 710

  Fly  1255 ANTQLRAAKKRDVRNLSISPTDLGPPPKTQQTTKGQSTRSKSSATPTPTPTSIHKRLNGTLASTA 1319
            .....|.|....||:.|:|..      .:..:|  .|||| ....|...|.|::..
Zfish   711 RLPPARLAAFGFVRSSSVSSV------SSNHST--DSTRS-DPCRPAYRPNSVNDE--------- 757

  Fly  1320 AIATPIKGVATKSGATNKLQQSAKTKSTASIKSPAIVGVSEESLRSGVDQTELQELNNGQSATGC 1384
               .|:..|.|                     ||...| |....||                  .
Zfish   758 ---PPLHRVTT---------------------SPPGDG-SRAPCRS------------------T 779

  Fly  1385 PTPPMARDSKRTSIGNELPCETEAKL---KRCEDQQDPQASTTASP--LPMINPQEQEASGQVKE 1444
            |.||......|.|:   ||....:.:   |..:...|...|:.:||  |.:::|:.|....|.::
Zfish   780 PQPPNTPAPVRRSL---LPPPRSSPVLSRKEFQKSSDGSRSSQSSPKRLAVVSPKPQSPVLQRQQ 841

  Fly  1445 ATITTANEPNALSLPDEISNSVSSTTMLATPRVDIAAQYPVLKPFTENGELDCARLAKFFQDTQF 1509
            .|.......:...||...|..:..                              :.|:..|..:.
Zfish   842 RTTVAVRGSSVQILPRSGSPGLEK------------------------------KKAEEEQKKEK 876

  Fly  1510 ERKEEQRQILGLSVM---VQFMSKELDAVACKENKHQCARTKGTLEKTILLLQH--------TQK 1563
            ||:|.:|.: .|.::   .:..:::|.|:     :.:..||...||..|:..||        .||
Zfish   877 EREEAERHV-ELQILQGRYEDQARKLQAL-----QTELKRTNMGLEVFIICTQHFSIKSESAEQK 935

  Fly  1564 DCE------RLREDLEDKGLEWIQRQQEKEYLHRTELKQA-EEKLMEVQLRAKLKFCELESQLRA 1621
            :.|      |::.::......|...|:||.     ||::. |::|.|:|::...:...||.:||.
Zfish   936 ERELSEELSRIQHEVAFNAARWEHLQKEKR-----ELEECFEKELRELQVQQNSELATLEEKLRL 995

  Fly  1622 KDEESKQAQEAYRMEVSHKLALKQEHLRTAEQ-KIQELQTRLQ-QVETEEQGHR---EELIRKEN 1681
            :.                  |..::|||...| :::||.|:.| |:|.....|.   |:|....|
Zfish   996 RH------------------ASDRDHLRAEHQSEVEELHTQHQEQIEELTANHEAALEDLKTMHN 1042

  Fly  1682 IHTARLAEANQR----------------EQD-------LIDRVKSLTKELNTLKANKEHNERDLR 1723
            |..|.|.|.:.|                |:|       |.|:|.:||.:..|||...:..|..||
Zfish  1043 ITMATLQEEHARTMRDLRKAHEQQKASLEEDFEKLRLSLQDQVDTLTFQNRTLKDKAKRFEEALR 1107

  Fly  1724 DRLALSQDEISVLRTSSQRRSPCTSLPDNASAELNRLTSEADSLRCVLELKQAEISALSKAKADL 1788
            .    |.||..|                :|.|....:..:..||:.|||:|..:|....|   .:
Zfish  1108 K----STDEQIV----------------DALAPYQHIEEDLKSLKEVLEMKNQQIHDQEK---KI 1149

  Fly  1789 IH----ESEERLKLSNRVALLEAQNEMLRTELEAKTEKEKEIQQKMEELQKAYKYESIKRTRLTY 1849
            .|    ::::.|.|..||.:|:.|||.|...::......:::.::...||:..:.|:.::.||:.
Zfish  1150 CHLEKVQAQKNLFLEERVQVLQQQNEDLMARIDRHLVASRQLSEENANLQENVEKETNEKKRLSR 1214

  Fly  1850 DKEELQYHLKQRSLQLQSAESKLQ-------DLSTGSHDNSLSSHSRCSLGRSGLEI-AVTTSSP 1906
            :.:||.: |.|.|..|..|.|.:.       |:...|:.....:.:..|....|... .|.:.:|
Zfish  1215 NNDELLW-LLQTSPHLSPASSPIHRAFFTGPDIPPYSYSPGPGTPTHSSSPGPGTPTHKVASPAP 1278

  Fly  1907 TSPVMKGMIERN 1918
            .:|..:|...|:
Zfish  1279 GTPTFRGSPARS 1290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toc	NP_477153.1	DUF390	<1302..1737	CDD:282014	102/485 (21%)
		RILP-like	<1550..1668	CDD:304877	34/134 (25%)
		COG1340	1580..1850	CDD:224259	75/302 (25%)
		YlqD	1642..>1712	CDD:287979	28/97 (29%)
		DUF4795	1652..1826	CDD:292662	53/205 (26%)
mtus2a	XP_005155337.1	SPEC	895..1083	CDD:295325	50/215 (23%)
		CEP63	936..1203	CDD:293650	75/312 (24%)
		RILP-like	<1012..1136	CDD:304877	37/143 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto39416
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24200
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7318
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.040