DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toc and Mtus2

DIOPT Version :9

Sequence 1:	NP_477153.1	Gene:	toc / 33526	FlyBaseID:	FBgn0015600	Length:	2162	Species:	Drosophila melanogaster
Sequence 2:	NP_001361029.1	Gene:	Mtus2 / 498136	RGDID:	1562533	Length:	1350	Species:	Rattus norvegicus

Alignment Length:	1547	Identity:	309/1547 - (19%)
Similarity:	513/1547 - (33%)	Gaps:	503/1547 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   653 LLKKQSSFDLDESLGILTPDQMKDFLDSPHNNLMHNLEMIRMHHPNLLQLRMEQTPSPEELPLDP 717
            |..|:|.|           .|::|..:...||   |..::|....|..|:.:|.:.|.:|    |
  Rat     5 LAPKKSCF-----------SQLRDHREGAKNN---NDNILRTGDTNANQIMLEVSASCDE----P 51

  Fly   718 IEIKSEIVKQVEASQNQVNTSQHSKLSNSFITSVTSVTSLDTGYQGDGEMSRPASRGACDHSPSN 782
               ||..:.....:.|......|    ..|......:..|..|.|......|.:......|...:
  Rat    52 ---KSRDLDDEIGNANLSRPQYH----GHFQKEPLHLQGLGKGSQAGSASQRDSQSSLTVHRQLS 109

  Fly   783 GPH-LGRVSRQ-------PSF----------PPPNPAPLRRQDPMTDSDFFTESDADDVLHRGDR 829
            ..| :.|.:.|       |||          .|...|.:.|..|   .|...::..::.|.|..|
  Rat   110 EEHTVKRGTLQTPQSIQGPSFSSWRNAVGQASPEVSAEIPRHTP---KDKLAKTLDNEELKRASR 171

  Fly   830 RAQVIDG-------QLYGPDMMQPSASVP-------------------QMEDSCMESSGIF---- 864
            .|....|       |...||:.:|...||                   ...|...|.:|:.
  Rat   172 SAAAAGGITPTTNPQPAQPDISEPQGHVPGHGEGPQGTPASHSPGKVFSPGDGTSEGNGVSLPKP 236

  Fly   865 --------------------TDVENRC----------------DEEMRQPELEF-------DVDM 886
                                .||.|:|                :..:..||:..       .|::
  Rat   237 STSEAKGSSPSDTKVEGTRGPDVHNQCTARAELTPSLASALRENPSLCHPEVYLGQGTGKPKVEL 301

  Fly   887 DMSPDDSSQTMRKGQGQPISTQQQQNQ--------LAPQQRPPSSCLSSSSAATTLSQSLSNRTS 943
            ......:.:.:...|.|.:..:::::.        |..:.|..:..|:||.....:.:
  Rat   302 KYIQPRNEEGLTSAQAQALVCREERSTSPVDRKELLEKEYREATGQLNSSQHQLGVGR------- 359

  Fly   944 YCSVDGGSARSFCGDEAFAAGRSTTTTAAAAAAAALSVQKTTSPRPHASLSSLCTVENFRGSVSS 1008
                 |||.....|..|...|....|.|.:||.|..:....|.
  Rat   360 -----GGSQEDGIGVSAGVEGSLQATPAPSAAPAGEAGTGLTG---------------------- 397

  Fly  1009 NSSIASPKSCKSSVTKTSAGKSRVLKSPKSPKSPK-----SPLNRKAHTPNKWDAVMNKIASNKS 1068
                           |.|||..|:.:...|.|:..     :|:.|   .||:
  Rat   398 ---------------KASAGAGRMARETASGKAAPDDGQVTPVLR---DPNE------------- 431

  Fly  1069 LIKTNYNDVKSKVS--TTRIMTPASGSSPVSGSGS--GSVSRTASSPRASP-SVSASARRSPSAT 1128
                   ...|:||  ..|:.:..|||:.:..||.  |. :||.:|...|| |.|..||:|....
  Rat   432 -------SAPSEVSGEERRLGSGNSGSAKLLASGPFVGG-NRTDASELLSPRSSSLEARKSKETV 488

  Fly  1129 PKVPPKMLLAKRPSSSS------GKVNATPSP---------PPHATPPTRQ-------PLDKGSV 1171
            ..|.....|.:..:.:.      ..|.:||:|         ..:.|||:..       .:|.||:
  Rat   489 TSVAEDKNLPENAAQTDVTPAGVDSVFSTPAPLHPETTVNLTEYLTPPSSSSQELGVFSVDTGSL 553

  Fly  1172 GAGSVGGGGARAVKT-PKSPTSPTTPT-----------TPTS----------------------- 1201
            ...|...||.:.:.| ||.|...|.|:           ||:|
  Rat   554 SVASAPTGGGQVLNTSPKVPDKTTCPSGIPKSLTHPKDTPSSQEALEKPETEKTEERTEAKPILM 618

  Fly  1202 PPAKRLQTSLVSRGRSYSKDSHKSSHTDLSLM----------CNASSSRPSNSASGSGSPKLLAN 1256
            |..|.::..:::..|   ::....|..|.||:          |  ....|....:.|..|.....
  Rat   619 PKPKHVRPKIITYIR---RNPQALSQGDASLVPVGLPYAPPAC--GMPLPQEEKASSLQPPANMY 678

  Fly  1257 TQLRAAKKRDVRNLSISPTDL---GPPPKTQQTTKGQSTRSKSSATPTP------TPTSIHKRLN 1312
            .:|    |.|::...:.|:.|   |..|.....:: .|.:.....|..|      :|...|..:.
  Rat   679 EKL----KPDLQKPRVFPSGLMVSGIKPPAHHFSQ-MSEKFLQEVTDHPGKEEFCSPPYTHYEVP 738

  Fly  1313 GTLASTAAIATPIKGVATKS---GATNKLQQSAKTKSTASIKSPAIVGVSEESLRSGVDQTELQE 1374
            .|...:|.:..|..|:...|   ...:::..:::..|..||..|..:..:....  |.|.::|:.
  Rat   739 PTFYRSAMLLKPQLGLGAMSRLPSTKSRILIASQRSSAGSIHPPGSIATATSFY--GSDPSDLKR 801

  Fly  1375 LNNGQSA-TGCP----TPP------------------------------------MARDSKRTSI 1398
            .:|..:| :|.|    .||                                    .:|...|.:.
  Rat   802 ASNSNAAKSGLPKSGLRPPGYSRLPAAKLAAFGFVRSSSVSAVPSTQSLDSAQQEQSRPVTRPTF 866

  Fly  1399 GNELPCETEAKLKRCEDQQD---------PQASTTASP-----LPMINPQEQEASGQVKEATITT 1449
            |:    |.:..||:....:|         |.:|:.|:|     ||........|..:.:......
  Rat   867 GS----EEQVSLKQAVPSKDTPKGAGRAAPASSSNATPPRRSLLPAPKSTSTPAGAKKEPQKDPE 927

  Fly  1450 ANEPNALSLPDEISNSVSSTTMLATPRVDIAAQYPVL-----------KPFTENGELDCARLAKF 1503
            |.:| |:|.|   ..:.|:||.|.:|      .||..           ||..:..|.: .:||:.
  Rat   928 AKKP-AVSSP---KRTASATTKLHSP------GYPKQRTTAPRNEVPPKPDLQAREAE-RQLAQR 981

  Fly  1504 FQDTQFERKEEQRQILGLSVMVQFMSKEL-------DAVACKENKHQCARTKGTLEKTILLLQHT 1561
            .:|    |.|.|.:.|||:      .:||       ||:|... ||...:::..|.|.    :..
  Rat   982 LRD----RCEWQARQLGLA------RRELKKAIQGFDAMAVSA-KHFFGKSERALAKE----KEL 1031

  Fly  1562 QKDCERLREDLEDKGLEWIQRQQEKEYLHRTELKQAEEKLMEVQLRAKLKFCELESQLRAKDEES 1626
            ..:...:|:::.....:..:.|:|||.|.|    :.||:|..:..:.:.:..||:.:|    ::.
  Rat  1032 SIELANIRDEVAFNTAKCEKLQKEKEALER----RFEEELRRLGWQQQAEVQELQERL----QQQ 1088

  Fly  1627 KQAQEAYRMEVSHK---LALKQEHLRTAEQKIQELQTRLQQVETEEQGHREELIRKENIHTARLA 1688
            .||:.| |::..|:   |.::.:|        ||      |||.....|...|:..||.||..:.
  Rat  1089 FQAESA-RLQAEHQDQMLRMRCQH--------QE------QVEDITASHEAALLEMENNHTVAIT 1138

  Fly  1689 ----EANQREQDLIDRVKSLTKELNTLKANKEHNERDLRDRLALSQDEISVLRTSSQRRSPCTSL 1749
                :.:.:.|:|:...:...|||       |.|...|  ||:| ||::..|...||      ||
  Rat  1139 ILQDDHDHKVQELMSTHEFEKKEL-------EENFEKL--RLSL-QDQVDTLTFQSQ------SL 1187

  Fly  1750 PDNAS------------------AELNRLTSEADSLRCVLELKQAEISALSKAKADLIHESEERL 1796
            .|.|.                  |....|..:..||:.|||:|..:|....|...:|....|:.:
  Rat  1188 RDRAQRFEEALRKTTEEQLEIALAPYQHLEEDMQSLKQVLEMKNQQIHLQEKKIIELEKLVEKNI 1252

  Fly  1797 KLSNRVALLEAQNEMLRTELEAKTEKEKEIQQKMEELQKAYKYESIKRTRLTYDKEELQYHLKQR 1861
            .|..::.:|:.|||.|:..::..|...:::.::...||:..:.|:.::.||:...|||
  Rat  1253 ILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEEL------- 1310

  Fly  1862 SLQLQSAESKLQDLSTGSHDNSLSSHSRCSLGRSGLEIAVTTSSPTSPVMKG 1913
                      |..|.||...:.:.                  .||||||.:|
  Rat  1311 ----------LWKLQTGDPTSPIK------------------LSPTSPVYRG 1334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toc	NP_477153.1	DUF390	<1302..1737	CDD:282014	112/523 (21%)
		RILP-like	<1550..1668	CDD:304877	27/120 (23%)
		COG1340	1580..1850	CDD:224259	74/294 (25%)
		YlqD	1642..>1712	CDD:287979	17/73 (23%)
		DUF4795	1652..1826	CDD:292662	50/195 (26%)
Mtus2	NP_001361029.1	PHA03247	<624..1007	CDD:223021	79/419 (19%)
Mtus2	NP_001361029.1	SbcC	1021..>1310	CDD:223496	78/331 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto96746
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24200
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010