DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toc and MTUS2

DIOPT Version :9

Sequence 1:	NP_477153.1	Gene:	toc / 33526	FlyBaseID:	FBgn0015600	Length:	2162	Species:	Drosophila melanogaster
Sequence 2:	XP_011533321.1	Gene:	MTUS2 / 23281	HGNCID:	20595	Length:	1399	Species:	Homo sapiens

Alignment Length:	1833	Identity:	363/1833 - (19%)
Similarity:	588/1833 - (32%)	Gaps:	636/1833 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 SSGIMGRTM--PVIPAKDATRTISANSSGLGNLTKVVRGVGNINQTLEAAGNITKTFRGAGDLTR 327
            ||...|.||  ||.|.|.....:..|.:...|..:.:..:|:.|     |..|......:.|.::
Human     3 SSPTKGLTMSVPVAPKKSCYTQLRDNRNAARNNNESILSLGDTN-----ANQIMLEVSSSHDESK 62

  Fly   328 TVEKEANIGKT----------FEVAANCTQTFTRGVNLTRTMNDKNEEVSRTIDKGRSTTKTIEV 382
            |.:....||.|          |....:..|.|.:| :...:.:.|:..:|.||.:..:...|:|.
Human    63 TCDLGDEIGNTNSSEPENRTHFHKEFHQLQGFGKG-SQAGSASLKDFRLSSTIQRELNEEHTVER 126

  Fly   383 GQNLTITMDAASNLTKSIDRGATLTNRGANLTKSVIEPGDFTKVIHQGANLTLSMDQLPLLEHIS 447
            |.:...|       |:||                            ||.:|:       ...::.
Human   127 GTDSLQT-------TRSI----------------------------QGPSLS-------SWRNVM 149

  Fly   448 MPSGLDILSSKCSGNVERPSQETDDTLDVTLTSLAPDKTNMKLPLNSTLNTERLLDISALQSPRH 512
            ..:.||:|:.:   :.|.|.....|                  .|..||:.|.|        .||
Human   150 SEASLDVLAKR---DAEIPRHVPKD------------------KLAKTLDNEEL--------RRH 185

  Fly   513 IQLLNLTQELERGTPSRVHLQSGRRSMPQHSLLCLSPQSATTTPHGMRMMGQATPQPVHLLSPLL 577
                    .|||.:.|...:.|   ..|||                        |||
Human   186 --------SLERASSSVAAVGS---LTPQH------------------------PQP-------- 207

  Fly   578 KQAQSALVLPTRTPDGDITMDGNGALDSTLTSTSVRGRTRYSFGLDLPDTTLDCSIELVDNSFSS 642
                  |.|.:|...|.|...|.|...:                  |||..:..:....|::...
Human   208 ------LSLDSREARGQIPGGGEGPQKT------------------LPDHAVPAAFPATDSTSEG 248

  Fly   643 STQLQQLQQQLLKKQSSFDLDESLGILTPDQMKDFLDSPHNNLMHNLEMIRMHHPNLLQLRMEQT 707
            .:...........|||:....:::|                             .::||:..|.|
Human   249 KSVRHPKPSTSESKQSTPSETQTVG-----------------------------AHVLQVCSEHT 284

  Fly   708 -----PSPE-ELPLDPIEIKSEIVKQVEASQNQVNTSQHSKLSNSFITSVTSVTSLDTGYQGDGE 766
                 |.|. .|.|...||.|::..|:...:.:      :||...::
Human   285 SHSAHPEPALNLTLASKEIPSKLEAQLGQGKGE------AKLDLKYV------------------ 325

  Fly   767 MSRPASRGACDHSPSNGPHLGRVSRQPSFPPPNPAPLRRQDPMTDSDFFTESDADDVLHRGDRRA 831
               |..|...:...:...:||....:      |.:.|..:||..::    ..:|.|.|
Human   326 ---PPRRVEQEGKAAQEGYLGCHKEE------NLSALEGRDPCGEA----HPEATDAL------- 370

  Fly   832 QVIDGQLYGPDMMQPSASVPQMEDSCMESSGIFTDVENRCDEEMRQPELEFDVDMDMSPDDSSQT 896
                |.|...|:......    ..:|.|..|:     |..:::          .:..:|...|.:
Human   371 ----GHLLNSDLHHLGVG----RGNCEEKRGV-----NPGEQD----------SLHTTPKQGSAS 412

  Fly   897 MRKGQGQPISTQQQQNQLAPQQRPPSSCLSSSSAATTLSQSLSNRTSYCSVDGGSARSFCGDEAF 961
            :.....||      ..:::|       |         ..:.|..|||               .:|
Human   413 LGGADNQP------TGKISP-------C---------AGEKLGERTS---------------SSF 440

  Fly   962 AAGRSTTTTAAAAAAAALSVQKTTSPRPHASLSSLCTVENFRGSVSSNSSIASPKSCKSSVTKTS 1026
            :.|.|         ..|......|..:|      |..:|..|...|.|..     |....|...|
Human   441 SPGDS---------HVAFIPNNLTDSKP------LDVIEEERRLGSGNKD-----SVMVLVFNPS 485

  Fly  1027 AGKSRV-LKSPKSPKSPKSPLNRKAHTPNKWDAVMNKIASNKSLIKTNYNDVKSKVS-------- 1082
            .|:::. :..|..|:|.:|.......       |...:|.|::|:: |.:.::|..:
Human   486 VGENKTEVPEPLDPQSGRSEARESKE-------VTTSVAENRNLLE-NADKIESTSARADSVLNI 542

  Fly  1083 ------------TTRIMTPASGSSPVSGSGSGSVSRTASSPRASPSVSASARRSPSATPKVP--- 1132
                        |.:..||:|....||..|     ..|.||...|..:.|||.. :.:||||
Human   543 PAPLHPETTVNMTYQPTTPSSSFQDVSVFG-----MDAGSPLVVPPPTDSARLL-NTSPKVPDKN 601

  Fly  1133 ------PKMLLA---KRPSSSSGKVN---------ATPSP-----PPHATPP-----TRQPLDKG 1169
                  ||.:..   ..|||..|..|         ....|     |.|..|.     .|.|...|
Human   602 TCPSGIPKPVFTHSKDTPSSQEGMENYQVEKTEERTETKPIIMPKPKHVRPKIITYIRRNPQALG 666

  Fly  1170 SVGAGSVGGGGARAVKTPKSPTSPTTPTTPTSPPAKRLQTSLVSRGRSYSK---DSHKSSHTDLS 1231
            .|.|..|..|         .|.:|.|.|.|.....|.....|......|.|   |..|.......
Human   667 QVDASLVPVG---------LPYAPPTCTMPLPHEEKAAGGDLKPSANLYEKFKPDLQKPRVFSSG 722

  Fly  1232 LMCNASSSRPSNSASGSGSPKLLANTQLRAAKKR----DVRNLSISPT----------DLG---- 1278
            ||  .|..:|........|.|.|........|:.    ...:..:.||          .||
Human   723 LM--VSGIKPPGHPFSQMSEKFLQEVTDHPGKEEFCSPPYAHYEVPPTFYRSAMLLKPQLGLGAM 785

  Fly  1279 ---PPPKTQQTTKGQSTRSKSSAT----PTPTPTSIHK-------RLNGT----LASTAAIATPI 1325
               |..|::.....|  ||.:||.    |..|.||::.       .|:||    ..|...::..:
Human   786 SRLPSAKSRILIASQ--RSSASAIHPPGPITTATSLYSSDPSGVHALSGTWFNYSGSLGDLSADL 848

  Fly  1326 KGVATKSGATNKLQQSAKTKSTASIKSP----------AIVGVSEESLRSGVDQTELQELNNGQS 1380
            |..::.:.|.:.|.:|       .::.|          |..|....|..|.|..|:     :|.|
Human   849 KKASSSNAAKSNLPKS-------GLRPPGYSRLPAAKLAAFGFVRSSSVSSVSSTQ-----SGDS 901

  Fly  1381 ATGCPTPPMARDSKRTSIGNELPCETEAKLKRCEDQQD----------PQASTTASPLPMINPQE 1435
            |    .|...|.:.|::.||    |.:..||.....:|          |.:|:..:|...:.|..
Human   902 A----QPEQGRPATRSTFGN----EEQPVLKASLPSKDTPKGAGRVAPPASSSVTAPRRSLLPAP 958

  Fly  1436 QEAS---GQVKEATITTANEPNALSLPDEISNSVSSTTMLATP----RVDIAAQY---PVLKPFT 1490
            :..|   |..|:|.........|:|.|..::   :|||.|.:|    :...||:.   |...|..
Human   959 KSTSTPAGTKKDAQKDQDTNKPAVSSPKRVA---ASTTKLHSPGYPKQRTAAARNGFPPKPDPQA 1020

  Fly  1491 ENGELDCARLAKFFQDTQFERKEEQRQILG---------------LSVMVQFMSKELDAVACKEN 1540
            ...|.......|       ||.|:|.:.||               |:|..|...::.::...||.
Human  1021 REAERQLVLRLK-------ERCEQQTRQLGVAQGELKRAICGFDALAVATQHFFRKNESALVKEK 1078

  Fly  1541 KHQCARTKGTLEKTILLLQ-------HTQKDCERLREDLEDKGLEWIQRQQEKE-----YLHRTE 1593
                       |.:|.|..       ||.| ||:|:::.|:     ::|:.|.|     :..:.|
Human  1079 -----------ELSIELANIRDEVAFHTAK-CEKLQKEKEE-----LERRFEDEVKRLGWQQQAE 1126

  Fly  1594 LKQAEEKLMEVQLRAKLKFCELESQ-------LRAKDEESKQAQEA------YRMEVSHKLA--- 1642
            |::.||:|   ||:.:.:...|:.:       :|.:.:|..:...|      ..||.:|.:|
Human  1127 LQELEERL---QLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITI 1188

  Fly  1643 LKQEHLRTAEQKIQELQT--RLQQVETEEQGHREELIRKENIHTARLAEANQREQDLIDRVKSLT 1705
            |:.:|    :.|:|||.:  .|::.|.|           ||....||:        |.|:|.:||
Human  1189 LQDDH----DHKVQELMSTHELEKKELE-----------ENFEKLRLS--------LQDQVDTLT 1230

  Fly  1706 KELNTLKANKEHNERDLRDRLALSQDEISVLRTSSQRRSPCTSLPDNASAELNRLTSEADSLRCV 1770
            .:..:|:......|..||..   :::::.:                 |.|....|..:..||:.|
Human  1231 FQSQSLRDRARRFEEALRKN---TEEQLEI-----------------ALAPYQHLEEDMKSLKQV 1275

  Fly  1771 LELKQAEISALSKAKADLIHESEERLKLSNRVALLEAQNEMLRTELEAKTEKEKEIQQKMEELQK 1835
            ||:|..:|....|...:|...:|:.:.|..::.:|:.|||.|:..::..|...:::.::...||:
Human  1276 LEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQE 1340

  Fly  1836 AYKYESIKRTRLTYDKEELQYHLKQRSLQLQSAESKLQDLSTGSHDNSLSSHSRCSLGRSGLEIA 1900
            ..:.|:.::.||:...|||                 |..|.||...:.:.
Human  1341 YVEKETQEKKRLSRTNEEL-----------------LWKLQTGDPTSPIK--------------- 1373

  Fly  1901 VTTSSPTSPVMKG 1913
               .||||||.:|
Human  1374 ---LSPTSPVYRG 1383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toc	NP_477153.1	DUF390	<1302..1737	CDD:282014	113/520 (22%)
		RILP-like	<1550..1668	CDD:304877	36/147 (24%)
		COG1340	1580..1850	CDD:224259	65/292 (22%)
		YlqD	1642..>1712	CDD:287979	19/74 (26%)
		DUF4795	1652..1826	CDD:292662	40/175 (23%)
MTUS2	XP_011533321.1	GBP_C	<1077..1181	CDD:303769	27/123 (22%)
		FAM184	1147..1364	CDD:292293	58/276 (21%)
		coiled coil	1153..1164	CDD:293879	2/10 (20%)
		RILP-like	<1244..1364	CDD:304877	32/156 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto89632
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24200
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7318
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.040