DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FASN1 and fasn

DIOPT Version :9

Sequence 1:	NP_001137778.2	Gene:	FASN1 / 33524	FlyBaseID:	FBgn0283427	Length:	2540	Species:	Drosophila melanogaster
Sequence 2:	XP_009305081.1	Gene:	fasn / 559001	ZFINID:	ZDB-GENE-030131-7802	Length:	2511	Species:	Danio rerio

Alignment Length:	2576	Identity:	1124/2576 - (43%)
Similarity:	1569/2576 - (60%)	Gaps:	260/2576 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 DEIAITGFSGRLPESSTIEEFKQNLFDGVDMVNDDPRRWERGLYGLPDRIGKLKDSDLENFDQQF 204
            ::|.|.|.|||||||:.:|||.||||:|||||.:|.|||:.||||||.|.||||  :::.||..|
Zfish     2 EDIVIAGISGRLPESNNLEEFWQNLFNGVDMVTEDDRRWKPGLYGLPRRNGKLK--EIDRFDAAF 64

  Fly   205 FGVHQKQAECMDPLLRMLLELTHEAIIDAGLNPSDLRGSRTGVYIGVSNSETEQHWCSDADRVNG 269
            ||||.|||..|||.||::||:::|||:|.|:||..:|||:||||||||.||..:.:..|.:.:.|
Zfish    65 FGVHPKQAHTMDPQLRLMLEISYEAIVDGGINPVSMRGSKTGVYIGVSGSEAGEAFSKDPEELLG 129

  Fly   270 YGLTGCARAMFANRISFTFDFKGPSYSIDTACSSSLYALEQAFSDMREGKVDNALVAGAGLILKP 334
            |.:|||.|||||||:|:.|||.|||.:|||||||||.|||.||:.:|.||.|.||:.|..|:|||
Zfish   130 YSMTGCQRAMFANRLSYFFDFNGPSTAIDTACSSSLLALENAFNAIRHGKCDAALIGGVNLLLKP 194

  Fly   335 TMSLQFKRLNMLSPDGSCKAFDESGNGYVRSDGCVVLLLQRTSAARRVYASILNVRTNTDGFKEQ 399
            ..|:||.:|.||||:|:||:||.|||||.||:..|.:||.:.|.|:|:||::||...||||:|||
Zfish   195 NTSVQFMKLGMLSPEGTCKSFDASGNGYCRSEAAVAVLLTKKSMAKRIYATVLNAGNNTDGYKEQ 259

  Fly   400 GITYPIGKMQNRLIRETYEEIGLNPADVVYVEAHGTGTKVGDPQEVNSITDFFCKDRTTPLLIGS 464
            |:|:|.|:||.||:|..|:|..::|..|.|:||||||||||||||||.|...||:.:..||||||
Zfish   260 GVTFPSGEMQQRLVRSLYQEANISPEQVEYIEAHGTGTKVGDPQEVNGIVSVFCQSQRDPLLIGS 324

  Fly   465 VKSNMGHSEPASGVCSVAKILIAMEEGVIPGNLHYNKPNPDLYGLVDGRLKVVDRNLPWNGGIIG 529
            .||||||.|||||:.::||:::::|.||...|:|:|:||||:..|.||||.||.:..|..|||:|
Zfish   325 TKSNMGHPEPASGLAALAKVVLSLEHGVWAPNVHFNEPNPDIPALTDGRLCVVSKPTPVRGGIVG 389

  Fly   530 LNSFGFGGANAHVILK---SNPKPKALTPKDGALKVVLASGRTFEAVEQLLESASTNADDDEYLQ 591
            :|||||||:|.||||.   |:...|  ||.....:::.|||||.|||..|..:|..:.::..||.
Zfish   390 INSFGFGGSNVHVILSPHVSDSSDK--TPAPSVPRLLQASGRTEEAVTALFSNAQQHQENSSYLS 452

  Fly   592 LINEIHSKAIPNHFFRGYGVVSSKGTHQREVIESNDDKRPIWYIYSGMGSQWASMAKDLMKIEAF 656
            |:|::.........:|||.::.::| ...||.::....||:|||.||||:|||.|.:.||::..|
Zfish   453 LLNDVSGVPTAGMPYRGYTLIGAQG-ELTEVQQTQPTPRPLWYICSGMGTQWAGMGQSLMQLSEF 516

  Fly   657 AKTIQRCADVLKPEGVDLIDVLTRSTDKSFENILNSFISIAAMQVALTDLLSSLGIHPDGIVGHS 721
            .::|:|....||..|:.:..:|..:.:.:||:.:::|:.:||:|||..|:|..:|:.|:||||||
Zfish   517 RESIKRSDIALKDTGLCVSRLLMEADESTFEDTVHAFVGLAAIQVAQIDMLRKMGLEPNGIVGHS 581

  Fly   722 VGELGCAYADGCFTPEQTVLAAYWRGKSILDTQLAKGKMAAVGLSWEDAHSRVPSDCFPVCHNSE 786
            ||||.|.||||..:..:.:|||||||:.|.:..|..|.||||||:||:..::.|....|.|||:|
Zfish   582 VGELACGYADGSLSHSEAILAAYWRGRCIKEANLPPGGMAAVGLTWEECKAQCPQGVVPACHNAE 646

  Fly   787 DNCTISGPEASIEALVAKLNAEGVFAKAVNSSGYAFHSKYIAEAGPKLRKSLEKIIPNAKNRTAR 851
            |..|||||:.|:...||:|...|||||.|.|:|.||||.|:|...|.|..:|:|:|.:.:.||||
Zfish   647 DTVTISGPQDSVSKFVAQLKESGVFAKEVRSAGVAFHSYYMASIAPALLSALQKVIKSPRPRTAR 711

  Fly   852 WISTSIPESAWNTPVAKQSSAAYHVNNLLSPVLFHEALQHVPKNAISVEIAPHGLLQAILKRALG 916
            |||||||:|.|.:|:|..|||.||||||:|||||.|.|.|||.||:.||||||.||||||||:|.
Zfish   712 WISTSIPQSDWESPLALYSSAEYHVNNLVSPVLFQEGLNHVPDNAVVVEIAPHALLQAILKRSLK 776

  Fly   917 PDATNLSLVKRGHENNVEFFLTNVGKLFAAGAQPQVLTLVRPISYPVGRGTPMLNSKVGWDHTQK 981
            |..:.|.|:||||.||:||||::|||::..|.......|...:.|||.||||:::..:.|||:|.
Zfish   777 PTCSILPLMKRGHANNLEFFLSHVGKVYMNGINVDSNKLYPAVKYPVPRGTPLISPYIQWDHSQS 841

  Fly   982 WLVAKF-----GKETSSGETIVEVDLSKED-DAFLAGHTIDGRILFPATGYMTLAWQTFAKMQGS 1040
            |.|.|.     |...|:..|:..:|::.|. |.::.||.||||:|:|||||:.|||:|..:..|:
Zfish   842 WDVPKVEDFPAGSGGSTSATVYNIDMNPESPDYYMIGHCIDGRVLYPATGYLVLAWRTLMRSLGT 906

  Fly  1041 EFHKTPVVMENLVFHRATILNKNAVVKFGINFFDGTGAFEICESGSLAVSGKITI---------- 1095
            ....|||..|::..||||||.|...|:..:.....|..||:.|:|:||||||:::
Zfish   907 VMDHTPVTFEDVTIHRATILPKTGSVQLEVRLMPATNRFEVSENGNLAVSGKVSVLEDSGLDAFH 971

  Fly  1096 -----PESIDNEELPLEEQTPSAVAKELGTNDVYKELRLRGYDYGGIFRGIVRSDTVASTGKLQW 1155
                 |.:.|||:..|          .|.:.|:||||||||||||..|:||:.|:....:|||.|
Zfish   972 AELNKPITADNEDPKL----------RLKSGDIYKELRLRGYDYGKTFQGILESNNAGDSGKLHW 1026

  Fly  1156 VDNWISFMDTMLQFSILSKNLRELYLPTRIERAVINPAKHFELLSALTKEEQVETGLPVQWYSDI 1220
            ..||::|:|||||..::....|.|.|||||....::|..|.|.::....:::.           :
Zfish  1027 TGNWVTFLDTMLQMIVVGLPGRSLRLPTRIRSVCVDPKLHEERVNDYEGDQKA-----------V 1080

  Fly  1221 NV--------IKSAGVELRGLKANLAQRRPGTQAPPTLERYQFVPNINTTDLNEN---------- 1267
            ||        |.:.||::.||.|..|.||...|.|||||.:.|||..:...|..|
Zfish  1081 NVFVNRCLDNITAGGVQICGLHATAAPRRQQQQTPPTLEEFVFVPYEDADCLRTNEKLADQLRHC 1145

  Fly  1268 -----------------------------------SEKARL------------------------ 1273
                                               :||..|
Zfish  1146 KGLVQRLQRKLAKQGVKISIPGLEGASEGQLIEAEAEKGLLRLLSVLCGLELNGNLRSELEQTVQ 1210

  Fly  1274 ----------------------HALDVAIQVIIENSS-GAVKLKGVELANGRNPDVLVANRLLQI 1315
                                  |.||.|    :|||: |..|:.....|:||     |.::.:.:
Zfish  1211 KERDCLLQDPLLNGLLDSQALRHCLDTA----LENSTPGKFKVLEALAADGR-----VFSQAVSL 1266

  Fly  1316 IEGEPVLTGDVAVVTSNNNEETITA---ALGDSGVRVVSKDVLKEPVEQ----------NCHFVF 1367
            :..:|:|..|  ...|:.:.:.::|   :|.:.|:.....|.|:.||..          ||
Zfish  1267 LNIQPMLRLD--YTASDISADQLSAQQSSLEEQGISTAQWDPLQGPVTGGLDGADLVVCNC---- 1325

  Fly  1368 GIDVLSRPDTKTLENSIASIRENGFLILE---------ETLPTYTKTG--RALLTKFGFVAV-QE 1420
            .:...:.| ...:||..::.||.||::|.         ||:...|...  :.|||:..:..: |:
Zfish  1326 AVGSATNP-ALLIENLTSAAREGGFILLHTLLRGDTLGETVAFLTSQNNRKGLLTQTEWEELFQK 1389

  Fly  1421 QSLGATRV--------LVLARKAVDLKTRKSVVVVATEQNFNWVDDLKAALATAATEEQYVYVVC 1477
            .||....:        |.|.|::.....::.:.:.....::.||:.||:.||.::....:: :..
Zfish  1390 ASLNVVMLRKSYYGSALFLCRRSQQSSQKQPIHIFVDPTDYKWVETLKSTLAESSDIPVWL-IAT 1453

  Fly  1478 QGEELFGAVGLMTCIKNENGGKLARLVFVQD----AKAEKFSLTSTLYRQQLEKDLISNVLKNGA 1538
            :|..  |.||::.|::.|.||...|..||.:    |..........:.:..|:|||:.||.::|.
Zfish  1454 KGHN--GVVGMVNCLRQEPGGNRIRCTFVSNLSKGAAVPSLLPNEKVMKALLKKDLVMNVHRDGL 1516

  Fly  1539 WGTFRHLKLETQQATLQV-EHAYVNALVKGDLASLKWIEAAQADTAATVDKNLETCTVYYAPINF 1602
            ||.||| :|.||..:.:: |.||||.|.:|||:||:||.:......|: ..|::.|.|||:.:||
Zfish  1517 WGVFRH-QLLTQDLSEELTEQAYVNVLTRGDLSSLRWIASPLRHFVAS-SPNVQLCRVYYSSLNF 1579

  Fly  1603 RDVMLTSGKLAADALPGDLAEQDCVLGLEFAGRDTQGRRVMAMVPAKSLATTCVASKRMMWQIPE 1667
            ||:||.:|||..||:|||:|.|.|:||:||:|||..|||||.::|||.|||...|.||.:|.:|.
Zfish  1580 RDIMLATGKLPPDAIPGDVALQQCMLGMEFSGRDPSGRRVMGLLPAKGLATCVDADKRFLWDVPS 1644

  Fly  1668 KWTMEEASTVPCVYSTVYYALVVRGQMKKGEKILIHAGSGGVGQAAISVALAHGLTVFTTVGSKE 1732
            .||:|:|::||.||:|.||:|||||:::.||.:|||:||||||||||::||:....|||||||||
Zfish  1645 SWTLEQAASVPVVYATAYYSLVVRGRLRPGESVLIHSGSGGVGQAAIAIALSMRCRVFTTVGSKE 1709

  Fly  1733 KREFLLKRFPKLQERNIGNSRDTSFEQLVLRETKGRGVDLVLNSLSEEKLQASIRCLGLNGRFLE 1797
            |:::|.:|||:|...:..||||:||||.|:..|:|:|||||||||:|||||||:|||..:|||||
Zfish  1710 KKQYLQERFPQLTAESFANSRDSSFEQHVMLNTQGKGVDLVLNSLAEEKLQASLRCLARHGRFLE 1774

  Fly  1798 IGKFDLSNNSPLGMSVFLKNTSFHGILLDSVMEGEEEMQNQVVSLVAEGIKTGAVVPLPTSVFND 1862
            |||:|||||:||||::||||.:|||||||::.|.......:|..|:.:||.:|.|.||.|:||..
Zfish  1775 IGKYDLSNNTPLGMALFLKNVAFHGILLDALFEEGNREWEEVSDLLKKGISSGVVQPLRTTVFER 1839

  Fly  1863 QQVEQAFRFMASGKHIGKVVIKVRDEEAGKKALQPKPRLINAIPRTYMHPEKSYILVGGLGGFGL 1927
            .|||:|||:||.|||||||:::||.||:...........|.||.||:.....|||:.||||||||
Zfish  1840 NQVEEAFRYMAQGKHIGKVLLQVRSEESSSSGPAVSALSIPAICRTFCPASLSYIITGGLGGFGL 1904

  Fly  1928 ELTNWLVTRGARYIVLTSRSGVKTGYQGLMIRRWQERGVKVVIDTSDVTTAAGAKKLLENSNKLA 1992
            ||..||..||||.:|||||||::.|||...:|.||..|::|::.||||:|..|.::|:..:.:|.
Zfish  1905 ELAQWLTERGARKLVLTSRSGIRNGYQAKRVREWQAMGIQVLVSTSDVSTLDGTERLITEACRLG 1969

  Fly  1993 LVGGIFNLAAVLRDALIEDQTAKDFKTVADPKVTATKYLDQFSRDICTELDYFICFSSVSCGRGN 2057
            .|||||:||.||:|.::|:.|.::|..|..||...|..||..:|..|.:|..|:.||||||||||
Zfish  1970 PVGGIFHLAMVLKDGMLENLTPQEFIEVNRPKYDGTINLDSVTRQKCPQLQQFVVFSSVSCGRGN 2034

  Fly  2058 IGQTNYGLANSAMERICEQRQVSGFPGTAIQWGAIGDTGLVLENLGDNDTVIGGTLPQRMPSCLQ 2122
            .||:|||.|||.||||||||:....||.|:|||||||.|:|||.:|.||.||||||||||.|||:
Zfish  2035 AGQSNYGFANSTMERICEQRRQENLPGLAVQWGAIGDVGVVLETMGGNDAVIGGTLPQRMSSCLE 2099

  Fly  2123 TIDLFLQQPHPVVASMVVAEK---RKSDQSAGVSLIATIANILGLRDTKNIQDGASLADLGMDSL 2184
            .:|.||.|..||::|.|:|||   .|.:.|....|:..:|:|||:||..::...|||||||:|||
Zfish  2100 VLDRFLCQQRPVMSSFVLAEKVVVTKGEGSGQKDLVEAVAHILGVRDVNSLNADASLADLGLDSL 2164

  Fly  2185 MSAEIKQTLERNFDIVLSAQEIRQLTFGALKAM---DGGADVKPAAAAPAAAAGVPEANITSGGS 2246
            |..|::|||||::|||::.:||||||...|:.:   .||.:..|...:.|      :|.:.|..|
Zfish  2165 MGVEVRQTLERDYDIVMAMREIRQLTINKLRELSKQSGGKEESPVKRSGA------QALLESDLS 2223

  Fly  2247 SRTASPMGDGTQVVFTTSLIPTEAIVQLDTKAPANSKQS---PIFFISPIEGFASALEPLAKRLE 2308
            ....:|.|                    .|.||.|..||   |:|.:.||||..:|...|..:|.
Zfish  2224 RMLVNPDG--------------------PTMAPLNEVQSAERPLFLVHPIEGSIAAFRTLTAKLS 2268

  Fly  2309 VPAYGLQYTEAVPSDSLESAAKFFIKQLRTVQPKGPYKLAGYSFGCLLTYVMAGILEETN-EVAN 2372
            ||.||||.|:|.|.||::|.|.::::.:|.||.:|||::||||||..:.:.|...|:... .|..
Zfish  2269 VPCYGLQCTKAAPLDSIQSLAAYYVECVRQVQLEGPYRIAGYSFGACVAFEMCSQLQLAKCPVEY 2333

  Fly  2373 VIMLDGAPSYVNWYTSSFKQRYTDGTNADNDNQSYGLAYFGIVLANIDYKALVRLLIVIPTWEEK 2437
            :.:.||:.|||..||.|::.:.|.|..::.:.::  |..|......|:|..|:..|:.:...|.:
Zfish  2334 LFLFDGSHSYVAAYTQSYRAKLTPGKESEAETEA--LCAFIQQFTGIEYNKLLETLLPLSDLEAR 2396

  Fly  2438 LERFAELMSNEITQPVETIKK-----SATLFYKKLELADGYQPTLKLKTNVTLVKPTDNSA---K 2494
            :::..:|    ||...:.:.:     :|:.||.||:.||.|.||.|...||||::...:|.   .
Zfish  2397 VDKAVDL----ITSSHKNVSRDMLHFAASTFYHKLKAADRYVPTSKYHGNVTLLRAKASSEYGDG 2457

  Fly  2495 LDEDYRLKEVCTKPVEVHTVEGNHRTFLIEDQSLKTIQSIL 2535
            |..||:|.|||...|.||.:||:||||| |.:.:::|.||:
Zfish  2458 LGSDYKLHEVCDGKVSVHVIEGDHRTFL-EGEGVESISSII 2497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FASN1	NP_001137778.2	PksD	137..1142	CDD:225858	518/1025 (51%)
		PKS	140..544	CDD:238429	240/403 (60%)
		KAsynt_C_assoc	502..612	CDD:292814	49/112 (44%)
		Acyl_transf_1	633..950	CDD:298668	168/316 (53%)
		hot_dog	990..1234	CDD:294345	96/267 (36%)
		NADB_Rossmann	1358..>1550	CDD:304358	55/225 (24%)
		PKS_ER	1593..1883	CDD:214840	177/289 (61%)
		enoyl_red	1595..1883	CDD:176179	176/287 (61%)
		KR_1_FAS_SDR_x	<1901..2141	CDD:187657	134/239 (56%)
		PKS_PP	2154..>2206	CDD:214834	27/51 (53%)
		Abhydrolase	2286..2535	CDD:304388	93/257 (36%)
fasn	XP_009305081.1	PksD	1..1014	CDD:225858	519/1026 (51%)
		PKS	2..404	CDD:238429	240/403 (60%)
		KAsynt_C_assoc	362..474	CDD:292814	49/113 (43%)
		Acyl_transf_1	493..810	CDD:279088	168/316 (53%)
		hot_dog	879..1070	CDD:294345	84/200 (42%)
		NADB_Rossmann	1331..>1530	CDD:304358	53/203 (26%)
		PKS_ER	1570..1860	CDD:214840	177/289 (61%)
		enoyl_red	1571..1860	CDD:176179	176/288 (61%)
		KR_1_FAS_SDR_x	<1863..2118	CDD:187657	137/254 (54%)
		PKS_PP	2134..>2186	CDD:214834	27/51 (53%)
		Abhydrolase	2245..2488	CDD:304388	91/249 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	352	1.000	Domainoid score	I968
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H131090
Inparanoid	1	1.050	2083	1.000	Inparanoid score	I43
OMA	1	1.010	-	-		QHG56071
OrthoDB	1	1.010	-	-		D19161at2759
OrthoFinder	1	1.000	-	-		FOG0001625
OrthoInspector	1	1.000	-	-		otm24450
orthoMCL	1	0.900	-	-		OOG6_100178
Panther	1	1.100	-	-	LDO	PTHR43775
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4095
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980